Prevalence of hepatitis C virus genotypes in the State of Pará, Brazil

Guimarães, Vanessa de Souza; Melo, Talita Gomes de; Ferreira, Rita de Cássia Damasceno; Almeida, Sherley Ferreira de; Martins, Luisa Carí­cio

doi:10.1590/0037-8682-0457-2017

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…In the state of Pará, prevalence rates of 65.7% and 23.3% had been previously observed in patients for genotypes 1 and 3, respectively 21 ; these prevalence rates are similar to those found in the present study. In addition, other studies also found a predominance of genotype 1 compared to genotype 3 in blood donors, and the frequencies of genotype 1 (from 89.1% 22 to 93.1% 23 ) were higher than those found in patients in this study.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, other studies also found a predominance of genotype 1 compared to genotype 3 in blood donors, and the frequencies of genotype 1 (from 89.1% 22 to 93.1% 23 ) were higher than those found in patients in this study. Unlike the present study, genotype 2 was detected in studies conducted by Sawada et al 23 and Guimarães et al 21 at frequencies of 0.6 and 4.4, respectively, indicating the presence of these genotypes in the state.…”

Section: Discussioncontrasting

confidence: 86%

“… 9 The predominance of subgenotype 1b has also been observed in the states of Amapá, Pará, Pernambuco and Roraima. 16 , 17 , 21 …”

Section: Discussionmentioning

confidence: 99%

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Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Castro

Amoras

Araújo

et al. 2020

The Brazilian Journal of Infectious Diseases

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 86%

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Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Castro

Amoras

Araújo

et al. 2020

The Brazilian Journal of Infectious Diseases

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“…There was a significant association between subtypes and age group, being genotype 1a the most prevalent in the age group 40–49 years. This data corroborates with the study of Guimarães and co-workers that underpins the idea of late diagnosis of chronic HCV infection and thus a historical predominance of genotype 1a [79]. The risk of HCV transmission via blood transfusion (12 %) in this study is low compared to previous study (38%) [80].…”

Section: Discussionsupporting

confidence: 91%

Simultaneous determination of HCV genotype and NS5B resistance associated substitutions using dried serum spots from São Paulo state, Brazil

Adeboyejo

Grosche

José

et al. 2022

Access Microbiology

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Hepatitis C virus (HCV) is responsible for more than 180 million infections worldwide, and about 80 % of infections are reported in Low and Middle-income countries (LMICs). Therapy is based on the administration of interferon (INF), ribavirin (RBV) or more recently Direct-Acting Antivirals (DAAs). However, amino acid substitutions associated with resistance (RAS) have been extensively described and can contribute to treatment failure, and diagnosis of RAS requires considerable infrastructure, not always locally available. Dried serum spots (DSS) sampling is an alternative specimen collection method, which embeds drops of serum onto filter paper to be transported by posting to a centralized laboratory. Here, we assessed feasibility of genotypic analysis of HCV from DSS in a cohort of 80 patients from São Paulo state Brazil. HCV RNA was detected on DSS specimens in 83 % of samples of HCV infected patients. HCV genotypes 1a, 1b, 2a, 2c and 3a were determined using the sequence of the palm domain of NS5B region, and RAS C316N/Y, Q309R and V321I were identified in HCV 1b samples. Concerning therapy outcome, 75 % of the patients who used INF +RBV as a previous protocol of treatment did not respond to DAAs, and 25 % were end-of-treatment responders. It suggests that therapy with INF plus RBV may contribute for non-response to a second therapeutic protocol with DAAs. One patient that presented RAS (V321I) was classified as non-responder, and combination of RAS C316N and Q309R does not necessarily imply in resistance to treatment in this cohort of patients. Data presented herein highlights the relevance of studying circulating variants for a better understanding of HCV variability and resistance to the therapy. Furthermore, the feasibility of carrying out genotyping and RAS phenotyping analysis by using DSS card for the potential of informing future treatment interventions could be relevant to overcome the limitations of processing samples in several location worldwide, especially in LMICs.

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“…Regarding sub-genotypes, the most prevalent subtype was 1b (42.1%). Studies carried out in other locations corroborate the results of this research, in the Eastern Amazon 16,21,22,23 , Paraguay and Colombia 24,25 , and recent studies from Northern, Southern and Eastern Europe have also shown the predominance of genotype 1 26,27,28 .…”

Section: Discussionsupporting

confidence: 89%

Liver Fibrosis in Individuals With Hepatitis C Virus Genotype 1B From Brazilian Eastern Amazon

Silva¹,

Dias²,

Quaresma³

et al. 2023

Preprint

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INTRODUCTION Hepatitis C virus (HCV) has a high genetic diversity, with seven genotypes with 86 subtypes. This genetic variability confers persistence in the infection and escape of the immune system with evolution to cirrhosis and cancer. Environmental factors can contribute to different disease progression, being essential to assess the viral genotype in the infection and discuss the environmental particularities of Eastern Amazon, and the frequencies of Liver fibrosis between different HCV genotypes in patients living in a region of the Brazilian Eastern Brazilian Amazon. METHODS Consists in an observational cross-sectional study. Sociodemographic and clinical data of 76 individuals diagnosed with Hepatitis C between 2019 and 2020 in public health services were selected. Data collected was tabulated in Microsoft Excel 2010TM spreadsheets and analysed in GraphPad Prism 5.0TM. Liver fibrosis was associated with genetic subtypes. RESULTS Subtype 1b was predominant (42.1%), followed by 1a (13%) and 3a (1.3%). 69.7% of participants had chronic hepatitis, with mild fibrosis (F1/F2) being the most prevalent (38.1%). Severe fibrosis was detected in 75% of individuals infected with the subtype 1b, that is associated with more severe disease. CONCLUSIONS We suggest further studies, to assess other communities in the region, as well as the monitoring of these patients with Liver Elastography to determine the disease evolution and its better management.

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Prevalence of hepatitis C virus genotypes in the State of Pará, Brazil

Abstract: Genotype 1 is the most predominant in Pará, which reinforces the idea of its relationship with late-diagnosed chronic infection.

Cited by 6 publications

References 12 publications

Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil

Simultaneous determination of HCV genotype and NS5B resistance associated substitutions using dried serum spots from São Paulo state, Brazil

Liver Fibrosis in Individuals With Hepatitis C Virus Genotype 1B From Brazilian Eastern Amazon

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