TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population

Abstract

Introduction: Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). Methods: Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. Results: G and C alleles of TGF-β1 (codon 25) were the most common in controls and patients, respectively.

Association between interleukin 10 (IL-10) polymorphisms and leishmaniasis progression: a systematic review and meta-analysis

“…Mishra et al 29 demonstrated that of the four SNPs analysed, only rs3024498 showed association with VL. However, Shehadeh et al 27 presented no association of IL-10 polymorphisms and VL progression, neither with rs1800871 nor rs1800896.…”

“…All eligible studies were published between 2013 and 2020. Two of the included studies were conducted in Iran 25 , 30 , three in Brazil 24 , 26 , 27 , one in India 29 , and one in Turkey 28 . Table 1 summarizes the characteristics of the studies included in the systematic review, and Table 2 shows the genotype and allele frequencies reported in the studies included in the meta-analysis.…”

“…Overall, three studies containing 312 cases and 1022 healthy controls were found to be eligible and included for quantitative analysis of association between the rs1800871 SNP and leishmaniasis progression 24 – 27 . Among these, one study analysed the VL form and three studies the CL form; these were included in the subgroup analysis.…”

“…This study did not show a relationship with any model and may emphasize that this polymorphism (rs1800896) cannot explain all forms of immune responses control in the patient. Innate and acquired immunity and other cytokines may also be involved in the pathogenesis 27 , 30 .…”

Multiparametric analysis of host and parasite elements in new world tegumentary leishmaniasis

“…We also acknowledge that several aspects of the host might influence cytokine levels, such as individual polymorphisms. Such gene polymorphisms can regulate the production and establishment of cytokines and determine patient susceptibility or resistance for TL and must be further investigated ( Amorim et al., 2019 ; Shehadeh et al., 2019 ; Lera-Nonose et al., 2021 ). Despite possible individual differences, the canonical analysis revealed different clusters for each manifestation, which was evident mainly for the group of asymptomatic patients compared to the others.…”