Necrotizing Orchitis due to COVİD-19

Aslan, Serdar

doi:10.1590/0037-8682-0408-2021

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Today, we know that the testis presents some conditions that might favor COVID-19 infection, such as the expression of ACE2, and the fact that Leydig cells of the testis receptors can act as the ACE2 receptor. This finding could explain the COVID-19 passage into the testicular microcirculation where reduced blood flow and presence of its receptor (ACE2) could enhance testicular infection [5,13,[17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19

Tavoosian

Ahmadi

Aghamir

2022

Case Reports in Urology

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Epididymo-orchitis is an infection of the epididymis and testis, one of the most common urogenital infections. It can be seen at any age. It is caused by sexually transmitted microorganisms and nonsexual transmitted pathogens. Viruses such as mumps and cytomegalovirus can also cause epididymo-orchitis. During the COVID-19 pandemic, in case of abnormal clinical manifestations of COVID infection and inadequate therapeutic response to the routine therapies, this disease with unusual manifestations should be considered. The case introduced in this paper is a 55-year-old man referred to a urology clinic with typical clinical presentations of epididymo-orchitis. Diagnosis by color Doppler examination and ultrasound also confirmed epididymo-orchitis. The patient underwent appropriate and routine treatment for epididymo-orchitis. Because of the lack of adequate clinical response and the continuation of fever and the development of scrotal lesions and the results of the control ultrasound, which suggested rupture of the tunica albuginea capsule, he underwent surgical exploration and subsequent orchiectomy. Due to the unconventional conditions and the usual culture and pathology, COVID-19 PCR was also performed on the tissues. The PCR showed tissue infection with COVID-19. The patient’s clinical condition improved with an orchiectomy, the fever stopped, and he was discharged in a good general condition. It should be noted that before referral to the urology clinic and during hospitalization, evaluation, and treatment, the patient had no evidence in favor of respiratory tract infection with the coronavirus.

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Section: Discussionmentioning

confidence: 99%

Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19

Tavoosian

Ahmadi

Aghamir

2022

Case Reports in Urology

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“…While viral detection and loads may differ depending upon the sample characteristics, the severity of the disease and the timing from the primary infection, a SARS-CoV-2 viremia has been an inconstant finding [12,20]. It should be further stressed that clinically evident orchitis in SARS-CoV-2 has been inconsistently reported [21][22][23], and recent reports and even a metanalysis showed an overall insignificant rate of detection of SARS-CoV-2 semen samples of COVID-19 patients [4,12]. A relatively old study reported the chance of orchitis as a manifestation of SARS-CoV [24], and some recent studies from SARS-CoV-2 infections reported associations with testicular discomfort [25] or testicular pain [21].…”

Section: Methodsmentioning

confidence: 99%

COVID-19 and its treatments: lights and shadows on testicular function

et al. 2022

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Purpose The SARS-CoV-2 pandemic has rapidly spread worldwide and, among the others, the male gender was quickly recognized as an independent risk factor for both the disease and its consequences. Since the possibility of long-term hormonal axis changes and male gamete impairment have been hypothesized but a relatively low levels of evidence has been reached, we focused this narrative mini-review on summarizing key state-of-the-art knowledge on male reproductive effects of COVID-19 as a quick reference for reproductive health specialists. Methods A comprehensive Medline/PubMed and Embase search was performed selecting all relevant, peer-reviewed papers in English published from 2020. Other relevant papers were selected from the reference lists. Results Available evidence indicates that the likelihood of direct testicular damage from SARS-CoV-2 is somewhat low, but there are many indirect ways (fever, cytokine imbalance, and drugs) through which the pituitary-gonadal axis and spermatogenesis may be disrupted. These alterations are probably transient, but as available evidence is low quality, it cannot be excluded that previous pathologies or comorbidities might modulate the risk of their persistence. On the other hand, available evidence shows high safety regarding andrological health for available vaccines, although studies are mainly focused on mRNA vaccines. Conclusion A careful andrological evaluation of men recovering from COVID-19 is highly recommended. Since available evidence is relatively scarce, a careful andrological follow-up and counseling of these patients are mandatory.

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“…The presence of SARS-COV-2 in saliva, respiratory fluids, blood, urine, and feces has been reported, and there is increasing evidence of SARS-COV-2 infection and inflammation in semen or testes [ 5 , 6 ]. The testes and epididymis of patients who died from COVID-19 exhibited pathological changes such as interstitial edema, congestion, germ cell destruction, thinning of germinal tubules, and increased spermatogenic epithelial detachment [ 5 , 7 ], which may further reveal the negative impact of COVID-19 on male fertility.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of semen DNA integrity and related parameters with COVID-19 infection: a prospective cohort study

Shi,

Hu,

Wang

et al. 2023

Virol J

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Background In the context of Corona Virus Disease 2019 (COVID-19) global pandemic, Its impact on male reproductive function should be concerned. Methods Our study is a prospective cohort study that recruited participants infected or uninfected with COVID-19 between December 2022 and March 2023. All laboratory tests and questionnaire data were completed at the First Affiliated Hospital of Nanchang University. A total of 132 participants were enrolled, with 78 COVID-19 positive patients as the positive group and 54 COVID-19 negative participants as the negative group. Semen quality was assessed by the fifth World Health Organization criteria. The general characteristics of semen samples were assessed using CASA (computer-assisted sperm analysis). DNA damage and the high density stainability was assessed by sperm chromatin structure analysis (SCSA) based on flowcytometry. Results The sperm concentration, progressive motility and motility in COVID-19 negative group were significantly higher than positive group. In the following DNA damage analysis, a remarkably lower sperm DNA fragmentation index (DFI) in the COVID-19 negative group. In the positive group, unhealthy lifestyles had no significant effect on semen parameters, DNA fragmentation and nuclear compaction. Conclusions After excluding the interference of unhealthy lifestyle, the COVID-19 infection can have a significant impact on the quality of semen, especially the DFI,. Therefore, it shows that COVID-19 can adversely affects male fertility, and this result provides advisory guidance for clinicians.

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Necrotizing Orchitis due to COVİD-19

Cited by 4 publications

References 2 publications

Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19

Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19

COVID-19 and its treatments: lights and shadows on testicular function

Evaluation of semen DNA integrity and related parameters with COVID-19 infection: a prospective cohort study

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