Buschke-Lowenstein tumor in a woman living with HIV/AIDS

Araújo, Paulo Sérgio Ramos de; Soares, Melina Ferraz

doi:10.1590/0037-8682-0396-2016

Cited by 5 publications

(5 citation statements)

References 2 publications

(3 reference statements)

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“…They also found that the extent of the viral warts was correlated with CD4 + T-cell count [100]. In this context, not surprisingly, BLT is more frequent in individuals with HIV infection [101][102][103][104][105] or on immunosuppressive drugs, such as patients with a history of stem cell or solid organ transplantation [106][107][108][109]. Risk of rapid progression of BLT into metastatic SCCs in HIV-infected patients is elevated [61,110].…”

Section: Secondary Immunodeficiencies In the Etiology Of Bltmentioning

confidence: 96%

The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

Purzycka-Bohdan

Nowicki

Herms

et al. 2022

IJMS

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Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Immunity to HPVs plays a crucial role in the natural control of various HPV-induced lesions. Large condyloma acuminata are frequently reported in patients with primary (e.g., DOCK8 or SPINK5 deficiencies) and secondary (e.g., AIDS, solid organ transplantation) immune defects. Individuals with extensive anogenital warts, including BLT in particular, should therefore be tested for inherited or acquired immunodeficiency. Research into the genetic basis of unexplained cases is warranted. An understanding of the etiology of BLT would lead to improvements in its management. This review focuses on the role of underlying HPV infections, and human genetic and immunological determinants of BLT.

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Section: Secondary Immunodeficiencies In the Etiology Of Bltmentioning

confidence: 96%

The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

Purzycka-Bohdan

Nowicki

Herms

et al. 2022

IJMS

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“…Fistulas commonly develop but seldom communicate with the anal canal and have never been reported communicating with the urethra. They are more analogous to the fistulas seen in perianal hidradenitis suppuritiva, with superficial connections between adjacent areas of B-L or rarely the intersphincteric region of the anal canal 14 . No evidence of transsphincteric fistulization is documented.…”

Section: Resultsmentioning

confidence: 76%

“…They are more analogous to the fistulas seen in perianal hidradenitis suppuritiva, with superficial connections between adjacent areas of B-L or rarely the intersphincteric region of the anal canal. 14 No evidence of transsphincteric fistulization is documented. Buschke-Lowenstein tumors can cause difficulty with perianal hygiene and are prone to localized infection.…”

Section: Clinical Presentation and Evaluationmentioning

confidence: 99%

Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Davis¹,

Barton²,

Orangio³

et al. 2021

Sexual Trans Dis

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Buschke-Lowenstein (B-L) tumors or giant condylomata are large fungating lesions that are caused by human papillomavirus (HPV) and develop in the anogenital region. Although uncommon, physicians and surgeons who treat sexually transmitted diseases or other diseases involving the anogenital area will encounter these patients. The purpose of this study is to review the current literature regarding these lesions. We evaluated every published study in PubMed and Embase from 1925 to 2020, concentrating on the clinical data included in each report, such as presentation and treatment. We also evaluated each work for any definition used and found that there is no accepted definition for these lesions. As such, we provide an inclusive, workable definition. In addition, there are many misconceptions about B-L that continue to be propogated as more case reports are published every year. After evaluating every published case, we refute the fact that these lesions have a high mortality or a high malignancy rate. Furthermore, we refute that these lesions are synonymous with verrucous carcinoma. In addition to a definition, we also propose a simple grading system that we hope can be used to assist in the study and management of these patients moving forward. Although the literature is very heterogenous regarding B-L, they are caused by HPV and are distinct from verrucous carcinoma. Because of the majority of information is based on case reports, the literature concentrates on treatment, but more work is clearly needed to delineate the association with specific HPV types and optimal management of this disease.

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“…Es muy agresivo localmente, con alta tasa de recurrencia (60% -70%) y potencial de malignización (30% -56%) [7]. Los principales factores de riesgo para su desarrollo son la infección por VPH, fumar, y los estados de inmunodepresión (Síndrome de Inmunodeficiencia Adquirida [SIDA], terapia inmunosupresora, alcoholismo, diabetes y quimioterapia) [8][9][10].…”

Section: Discussionunclassified

Tumor de Buschke – Löwenstein

Leone¹,

Carvajal²

2022

Rev. Oncol. Ecu.

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Introducción: El tumor de Buschke – Lowenstein (TBL) es enfermedad de transmisión sexual causada por el virus del papiloma humano (VPH), descrita como una forma intermedia entre un condiloma acuminado y un carcinoma de células escamosas. Afecta principalmente al área genital y anorrectal, posee capacidad de transformación maligna y una alta tasa de recurrencia. La cirugía es el tratamiento de primera línea. Caso clínico: Presentamos el caso de un paciente masculino de 27 años con lesiones verrucosas de crecimiento progresivo en el área inguinal y genital. Mediante la correlación clínico-patológica se llegó al diagnóstico de TBL. Tras discusión en comité multidisciplinario se declaró irresecable y se resolvió tratamiento con radioterapia, además vacunación terapéutica contra el VPH, tanto sistémica como intralesional. Conclusión: El TBL es localmente agresivo y de difícil tratamiento, por lo que la prevención contra el VPH es fundamental. La vacunación terapéutica en conjunto con la radioterapia ofreció mejoría clínica.

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Buschke-Lowenstein tumor in a woman living with HIV/AIDS

Cited by 5 publications

References 2 publications

The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview

Buschke-Lowenstein Tumors: A Review and Proposed Classification System

Tumor de Buschke – Löwenstein

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