Frequency of histopathological changes in Howler monkeys ( Alouatta sp.) naturally infected with yellow fever virus in Brazil

Leal, Silvana Gomes; Romano, Alessandro; Monteiro, Rafael Veríssimo; Melo, Cristiano Barros de; Vasconcelos, Pedro Fernando da Costa; Castro, Márcio Botelho de

doi:10.1590/0037-8682-0363-2015

Cited by 30 publications

(27 citation statements)

References 16 publications

(28 reference statements)

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“…Most of the knowledge about the pathogenesis of YF in humans and NHP results from experimentally infected rhesus monkeys (Macaca mulatta), Alouatta spp., and Saimiri spp. [114,139]. The first successful infection of a rhesus monkey with YFV was demonstrated in 1928, by Stokes and colleagues (1928).…”

Section: Pathogenesis Of Yellow Fever In Non-human Primatesmentioning

confidence: 99%

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Silva

Sacchetto

Rezende

et al. 2020

Virol J

108

132

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Yellow fever (YF) is an acute viral disease, affecting humans and non-human primates (NHP), caused by the yellow fever virus (YFV). Despite the existence of a safe vaccine, YF continues to cause morbidity and mortality in thousands of people in Africa and South America. Since 2016, massive YF outbreaks have taken place in Brazil, reaching YF-free zones, causing thousands of deaths of humans and NHP. Here we reviewed the main epidemiological aspects, new clinical findings in humans, and issues regarding YFV infection in vectors and NHP in Brazil. The 2016-2019 YF epidemics have been considered the most significant outbreaks of the last 70 years in the country, and the number of human cases was 2.8 times higher than total cases in the previous 36 years. A new YFV lineage was associated with the recent outbreaks, with persistent circulation in Southeast Brazil until 2019. Due to the high number of infected patients, it was possible to evaluate severity and death predictors and new clinical features of YF. Haemagogus janthinomys and Haemagogus leucocelaenus were considered the primary vectors during the outbreaks, and no human case suggested the occurrence of the urban transmission cycle. YFV was detected in a variety of NHP specimens presenting viscerotropic disease, similar to that described experimentally. Further studies regarding NHP sensitivity to YFV, YF pathogenesis, and the duration of the immune response in NHP could contribute to YF surveillance, control, and future strategies for NHP conservation.

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Section: Pathogenesis Of Yellow Fever In Non-human Primatesmentioning

confidence: 99%

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Silva

Sacchetto

Rezende

et al. 2020

Virol J

108

132

View full text Add to dashboard Cite

show abstract

“…They can also play an important role as reservoir or in the spillover to human population as, for example, in the origin as ZIKV and in the enzootic cycle of the sylvatic DENV in Southeast Asia and West Africa (Vasilakis et al., ). Recently, massive deaths of NHP have been reported in Brazil associated to the presence of Yellow Fever virus (YFV) (Leal et al., ; Moreno et al., ). Additionally, previous studies have reported the presence of Zika virus (ZIKV) in NHP, including capuchin monkeys, from Northeast Brazil (Favoretto et al., ) as well as the antibody presence against several arboviruses in Brazilian capuchin monkeys (Laroque et al., ).…”

Section: Frequency Of Positive Samples On the Prnt90 Per Flavivirusesmentioning

confidence: 99%

Seroprevalence of selected flaviviruses in free-living and captive capuchin monkeys in the state of Pernambuco, Brazil

Oliveira-Filho

Oliveira

Ferreira

et al. 2018

Transbound Emerg Dis

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Mosquito-borne diseases such as dengue, yellow fever and, more recently, Chikungunya virus (CHIKV) and Zika virus (ZIKV) have a great impact in the public health. In addition, the presence of such viruses might have an impact on wild animal conservation as well as their possible role as animal reservoir. Here, we performed a serological survey searching for antibodies against a panel of flaviviruses [ZIKV, Dengue virus (DENV), Yellow Fever virus (YFV), West Nile virus (WNV), Saint Louis Encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV)] using plaque reduction neutralization test (PRNT ) in both free-ranging and captive capuchin monkeys (Sapajus flavius and Sapajus libidinosus). Captive and free-living monkeys were sampled between June 2015 and January 2016 in the state of Pernambuco, including in the border with State of Paraíba, the epicentre of the ZIKV epidemics in Brazil. We have found neutralizing antibodies for ZIKV, DENV-1, DENV-2, DENV-3, DENV-4, YFV, ILHV and SLEV in both S. flavius and S. libidinosus samples. No positives samples were found for ROCV and WNV. Our results suggest that these flaviviruses might be circulating in capuchin monkey in the studied region. The possible presence of these viruses represents a risk for public health, as well as for animal conservation, especially for S. flavius which is a critically endangered species, facing high risk of extinction.

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“…By the 18th century, epidemics were already deemed a threat for public health in the Old and New Worlds; transoceanic migrations played a major role in virus spread ( 3 , 6 ). After entering Brazil by the coast in the 17th century, the virus was gradually displaced to northwestern and midwestern areas.…”

mentioning

confidence: 99%

Outbreak of Yellow Fever among Nonhuman Primates, Espirito Santo, Brazil, 2017

Fernandes¹,

Cunha²,

Guerra³

et al. 2017

Emerg. Infect. Dis.

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Frequency of histopathological changes in Howler monkeys ( Alouatta sp.) naturally infected with yellow fever virus in Brazil

Cited by 30 publications

References 16 publications

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Seroprevalence of selected flaviviruses in free-living and captive capuchin monkeys in the state of Pernambuco, Brazil

Outbreak of Yellow Fever among Nonhuman Primates, Espirito Santo, Brazil, 2017

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