Comparison of Inflammatory Markers between Adult and Pediatric Brucellosis Patients

Tekin, Recep; Aktar, Fesih; Yılmaz, Kamil; Tekin, Salih; Ayaz, Celal

doi:10.1590/0037-8682-0356-2019

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…A study by Patel et al [24] was similar to our results, and it was signi cantly higher in RDW and signi cantly lower in NLR levels of brucella epididymo-orchitis when compared to non-brucella epididymo-orchitis. The study by Tekin et al [22] and the study by Küçükbayrak et al [16] was similar to ours as well. However, Togan et al [15] reported RDW level was not signi cantly higher in the acute brucellosis patients compared to that of the controls.…”

Section: Discussionsupporting

confidence: 91%

“…Although there are a few studies about the hematologic effects of the brucellosis in literature [15,22,23], not precisely clear pathogenesis of alteration in RDW, which may be associated with morbidity in this disease, is still lacking. Our ndings showed that RDW levels were signi cantly higher in brucellosis group when compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the Relationship Between Red Cell Distribution Width and Brucellosis: A Case-Controlled Study

Gou

Gao

Lan

et al. 2021

Preprint

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Background: As a multisystem infectious disease, there is inflammation, which causes an increase in brucellosis. The red cell distribution width (RDW) has been identified as markers of inflammation. The present study aimed to investigate the predictive contribution value of RDW in the diagnosis of brucellosis.Methods: Medical records of 398 patients with brucellosis and 398 age-matched and gender-matched healthy controls in a single center from January 2017 to December 2019 were retrospectively reviewed.Results: The mean age of brucellosis patients was 47.1±12.9 years. The RDW levels were significantly higher in brucellosis group when compared to the control group (p < 0.001); The RDW levels were markedly lower in brucellosis male patients（14.32±2.15%）when compared to the brucellosis female patient（s 15.41±3.13%）(t= -9.56, p < 0.001). The biochemical markers of brucellosis patients included erythrocyte, hemoglobin, HCT, corpuscular volume, hemoglobin, hemoglobin concentration were all negatively correlated with RDW (r = −0.227, -0.383, -0.266, -0.253, -0.311 and -0.225, all p < 0.001). The values of hemoglobin (β coefficient = -0.084, p < 0.001), ESR (β coefficient = -0.020, p = 0.004) were significantly and independently correlated with RDW. Receiver operating characteristic (ROC) curve analysis showed that the best cutoff point for RDW in the diagnosis of brucellosis was 13.45%, which evaluated brucellosis with a sensitivity of 64.1% and a specificity of 83.9%. The area under the ROC curve for RDW was calculated as 0.80 (95% CI 0.769–0.831, P<0.001).Conclusion: This study revealed that the RDW in diagnosing brucellosis had a higher sensitivity and specificity. RDW values may be useful complementary indirect markers for the diagnosis of brucellosis.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Assessment of the Relationship Between Red Cell Distribution Width and Brucellosis: A Case-Controlled Study

Gou

Gao

Lan

et al. 2021

Preprint

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“…Adults with CSU had higher NLR and PLR than children with CSU. Our findings regarding increased NLR in adults are similar to those in patients with atopic dermatitis and brucellosis ( 15 ). However, this study did not find any significant difference in PLR between children and adults.…”

Section: Discussionsupporting

confidence: 86%

Increased Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Chronic and Severe Urticaria

Weissmann,

Burrack,

Golan-Tripto

et al. 2024

Acta Derm Venereol

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Chronic spontaneous urticaria (CSU) is a disturbing skin condition often severely detrimental to quality of life. Haematological markers of inflammation such as neutrophil-to-lymphocyte and platelet-to-lymphocyte may be used in the assessment of inflammatory skin diseases. Their usefulness in urticaria is unknown. Neutrophil- to-lymphocyte, platelet-to-lymphocyte, and total serum IgE were investigated in urticaria patients: acute spontaneous urticaria (ASU) versus CSU, children versus adults with CSU, and patients with mild-to-moderate versus severe CSU. This retrospective cohort study included patients of all ages diagnosed with urticaria between 2005 and 2020 and blood counts within 30 days of diagnosis. Patients with comorbidities influencing blood cells (infection, surgery, malignancy) were excluded. Neutrophil-to-lymphocyte and platelet-to-lymphocyte were evaluated in patients with ASU vs CSU and mild-to-moderate CSU vs severe CSU (defined by the use of systemic medications or hospitalizations). A total of 13,541 urticaria patients were included in the study. CSU patients (n = 5,021) had higher neutrophil-to-lymphocyte and platelet-to-lymphocyte, as well as serum IgE levels compared with ASU patients (n = 8,520). Adults had higher neutrophil-to-lymphocyte and platelet-to-lymphocyte than children. Severely affected patients (n = 53) had higher neutrophil-to-lymphocyte and platelet-to-lymphocyte compared with mild-to-moderately affected patients (n = 4,968). Patients with higher neutrophil-to-lymphocyte and platelet-to-lymphocyte had higher odds of having CSU rather than ASU and severe urticaria rather mild-to-moderate. In conclusion, neutrophil-to-lymphocyte and platelet-to-lymphocyte are simple and available markers that can be used to predict and assess severe and chronic urticaria.

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“…A previous study showed that adult patients with brucellosis had a significantly higher Neutrophil to Lymphocyte ratio (NLR) compared to children. Existing literature also highlights that higher NLR values are observed in inflammatory processes compared to the non-inflammatory ones, therefore NLR may be used in the diagnosis and follow-up of brucellosis cases [16]. An additional study also suggested that increased serum levels of hepcidin (compared to the CRP levels) in patients with brucellosis can be used as a diagnostic biomarker of inflammation and active disease [17].…”

Section: Discussionmentioning

confidence: 99%

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

Chen

et al. 2021

J Infect Dev Ctries

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Introduction: Brucellosis is a zoonosis with a wide spectrum of clinical manifestations. However, it is still unclear whether the clinical manifestations in children are significantly different from those in adults. Methodology: Patients with brucellosis and treated at the General Hospital of Ningxia Medical University between 2009 and 2019 were divided into two groups; children (88) and adults (354). Thereafter, the records of the two groups were analyzed retrospectively. Results: The findings showed that: 1. School-age children, young and middle-aged individuals were more likely to suffer from brucellosis and most were male; 2. Fever and arthralgia were the most common manifestations in the two groups. In addition, fatigue and low back pain were rare in children although fever and lymphadenopathy were more common in this group. However, hepatomegaly and splenomegaly were common in both groups; 3. The most common complication was osteoarthritis and peripheral arthritis occurred more frequently in children. On the other hand, spondylitis was the most common in adults (this particularly involved the lumbar and sacral vertebrae); 4. An increase in the erythrocyte sedimentation rate, levels of the C-reactive protein and liver enzymes was common in both two groups; 5. There was no significant difference in the positive rate of the standard agglutination test between children (96.59%) and adults (95.20%). However, the positive rate of blood culture was higher in children (65.85%) than in adults (51.00%). Conclusions: Brucellosis causes damage to multiple systems and differences in clinical characteristics were found between children and adults.

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Comparison of Inflammatory Markers between Adult and Pediatric Brucellosis Patients

Cited by 9 publications

References 12 publications

Assessment of the Relationship Between Red Cell Distribution Width and Brucellosis: A Case-Controlled Study

Assessment of the Relationship Between Red Cell Distribution Width and Brucellosis: A Case-Controlled Study

Increased Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Chronic and Severe Urticaria

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

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