Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits

Oliveira, Flávio Augusto de Souza; Passarini, Guilherme Matos; Medeiros, Daniel Sol Sol de; Santos, Ana Paula de Azevedo dos; Fialho, Saara Neri; Gouveia, Aurileya de Jesus; Latorre, Marcinete; Freitag, Elci Marlei; Medeiros, Patrícia de Maria de Soares; Teles, Carolina Bioni Garcia; Facundo, Valdir Alves

doi:10.1590/0037-8682-0309-2017

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…Piplartine also shows benefits in the treatment of the parasitic infection schistosomiasis, caused by helminth flatworms of the genus Schistosoma [11]. Compounds from Piper tuberculatum fruits show antiplasmodial and antileishmanial activities [12]. All these activities of Piper plants on neglected tropical diseases are very important for pantropical regions, which are the natural habitats of these plants.…”

Section: Introductionmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

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Section: Introductionmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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“…In this context, we can highlight plants of the genus Piper L., Piperaceae which have components such as: amides, alkaloids, derivatives of benzoic acid, lignans, flavonoids and cinnamic acid (Facundo et al, 2008;Regasini et al, 2009). There are reports in the literature of trypanocidal, leishmanicidal and anti-inflammatory bioactivity for this genus (Calderon et al, 2009;Santos et al, 2018;Oliveira et al, 2018). In addition, there are other studies and reviews published in the literature demonstrating specific action of molecules derived from cinnamic acid (Guzman, 2014).…”

Section: Introductionmentioning

confidence: 99%

In vitro and ex vivo antiplasmodial activity of 1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one) against circulating strains of Plasmodium spp. in the state of Rondônia, Brazil

Vicentini

Nascimento

Almeida

et al. 2022

Braz. J. Pharm. Sci.

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Malaria is a disease caused by Plasmodium spp. protozoa. The ability of Plasmodium to develop resistance to current antimalarial drugs makes the study of chemotherapeutic alternatives extremely important. This study aimed to evaluate the antimalarial activity of compound 3286938(1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one), which presents in its structure a 3,4,5-trimethoxyphenyl group, in vitro, using the W2 strain of P. falciparum and against circulating strains of P. vivax and P. falciparum from the state of Rondônia. The compound 3286938 obtained an IC 50 of 24.4 µM against the W2 strain of P. falciparum, and against the circulating strains, it presented a median (MD)=38.7 µM for P. vivax and MD=6.7 µM for P. falciparum. As for toxicity, 3286938 showed CC 50 > 500 µM for VERO and HepG2 strains with a selectivity index greater than 12.9, a ratio calculated for P. falciparum and P. vivax regarding Vero and HepG2 cells. The compound was not considered hemolytic in in vitro assays, thus indicating the specificity of its antiplasmodial action. Based on the results presented, and considering the unprecedented character of the compound, it can be concluded that 3286938 was shown to be promising for complementary in vitro and in vivo studies aiming to produce effective antiplasmodial action.

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Traditional Chinese Medicines for Malaria Therapy

Lu,

Wang,

Wang

2023

Malaria Control and Elimination in China

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Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits

Cited by 10 publications

References 13 publications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

In vitro and ex vivo antiplasmodial activity of 1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one) against circulating strains of Plasmodium spp. in the state of Rondônia, Brazil

Traditional Chinese Medicines for Malaria Therapy

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