The burden of low back pain, rheumatoid arthritis, osteoarthritis, and gout and their respective attributable risk factors in Brazil: results of the GBD 2017 study

Wolf, Juliana; França, Elisabeth Barboza; Assunção, Ada Ávila

doi:10.1590/0037-8682-0285-2021

Cited by 8 publications

(6 citation statements)

References 48 publications

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“…Previous studies have reported that NF-κB contributes to IL-1β-provoked cell damage. 1 In our study, we used Western blotting assay to evaluate the influence of MA on the IL-1β-induced chondrocytes. As demonstrated in Figure 4A and B , compared to the DMSO group, p/t-IκBα expression was significantly increased in the IL-1β treated group, while MA treatment inhibited the phosphorylation of IκBα.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have reported that NF-κB contributes to IL-1β-provoked cell damage. 1 In our study, we used Western blotting assay to evaluate the influence of MA on the IL-1β-induced chondrocytes. As demonstrated in Figure 4A and B, As demonstrated in Figure 4C and D, IL-1β stimulation inhibits the phosphorylation levels of PI3K and AKT, while MA treatment restores the p/t-PI3K and p/t-Akt.…”

Section: Ma Protects Chondrocyte Via Inhibiting Nf-κb/iκbα and Regula...mentioning

confidence: 99%

“…Osteoarthritis (OA) is among the diseases with the most rapid increase in prevalence, which places a significant burden on society and finance, and there is presently no effective treatment besides late replacement surgery and symptomatic relief. 1 , 2 Today, OA can also be defined as a pathology of the “osteochondral unit”, which combined of articular cartilage, calcified cartilage, subchondral cortical and trabecular bone. This unit functions primarily by transferring load-bearing weight over the joint to allow for normal joint articulation and movement.…”

Section: Introductionmentioning

confidence: 99%

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Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study

Fu¹,

He²,

Wang³

et al. 2022

DDDT

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Purpose Osteoarthritis (OA) places a significant burden on society and finance, and there is presently no effective treatment besides late replacement surgery and symptomatic relief. The therapy of OA requires additional research. Madecassic acid (MA) is the first native triterpenoid compound extracted from Centella asiatica, which has a variety of anti-inflammatory effects. However, the role of MA in OA therapy has not been reported. This study aimed to explore whether MA could suppress the inflammatory response, preserve and restore chondrocyte functions, and ameliorate the progression of OA in vitro and in vivo. Methods Rat primary chondrocytes were treated with IL-1β to simulate inflammatory environmental conditions and OA in vitro. We examined the effects of MA at concentrations ranging from 0 to 200 µM on the viability of rat chondrocytes and selected 10 µM for further study. Using qRT-PCR, immunofluorescent, immunocytochemistry, and Western blotting techniques, we identified the potential molecular mechanisms and signaling pathways that are responsible for these effects. We established an OA rat model by anterior cruciate ligament transection (ACLT). The animals were then periodically injected with MA into the knee articular cavity. Results We found that MA could down-regulate the IL-1β-induced up-regulation of COX-2, iNOS and IL-6 and restore the cytoskeletal integrity of chondrocytes treated with IL-1β. Moreover, MA protects chondrocytes from IL-1β-induced ECM degradation by upregulating ECM synthesis related protein expression, including collagen-II and ACAN, and further down-regulating ECM catabolic related protein expression, including MMP-3 and MMP-13. Furthermore, we found that NF-κB/IκBα and PI3K/AKT signaling pathways were involved in the regulatory effects of MA on the inflammation inhibition and promotion of ECM anabolism on IL-1β-induced chondrocytes. Conclusion These findings suggest that MA appears to be a potentially small molecular drug for rat OA.

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Section: Resultsmentioning

confidence: 99%

“…Previous studies have reported that NF-κB contributes to IL-1β-provoked cell damage. 1 In our study, we used Western blotting assay to evaluate the influence of MA on the IL-1β-induced chondrocytes. As demonstrated in Figure 4A and B, As demonstrated in Figure 4C and D, IL-1β stimulation inhibits the phosphorylation levels of PI3K and AKT, while MA treatment restores the p/t-PI3K and p/t-Akt.…”

Section: Ma Protects Chondrocyte Via Inhibiting Nf-κb/iκbα and Regula...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study

Fu¹,

He²,

Wang³

et al. 2022

DDDT

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“…Our findings corroborate this previous study. Interestingly, our results showed a significant increase in ASP, incidence, and YLDs in both men and women from 2000 to 2005, which may be a result of complex factors including an economic boom and income inequality [ 36 ], an obesity epidemic [ 37 , 38 ], longer life expectancy [ 39 ], an aging population [ 40 ], an increase in public health awareness, and medical system reform.…”

Section: Discussionmentioning

confidence: 99%

Increasing Burden of Osteoarthritis in China: Trends and Projections from the Global Burden of Disease Study 2019

Hu,

Li,

Zhang

et al. 2024

Med Sci Monit

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Background This study aimed to evaluate the epidemiology of osteoarthritis in China in a comprehensive and reliable way, to project its future epidemiological patterns, and to mitigate its health hazards. Material/Methods Data were extracted and analyzed from the Global Burden of Diseases Study 2019. Trends in osteoarthritis epidemiology were explored using joinpoint regression analysis. Additionally, we analyzed dynamic trends using the sociodemographic index (SDI) of China. To assess and predict the epidemiology of osteoarthritis from 2020 to 2039, we used both the Bayesian age-period-cohort model and Nordpred model. Results The number of prevalent cases, incident cases, and years lived with disability (YLDs) for osteoarthritis in China increased from 51.8, 4.6, and 1.8 million, respectively, in 1990, to 132.8, 10.7, and 4.7 million, respectively, in 2019, and the average annual percentage changes were 3.286, 2.938, and 3.324, respectively. The prevalence and YLDs peaked in the population aged over 90 years old, while the incidence peaked in the population aged around 50 years old. A significant positive correlation was found between osteoarthritis burden and SDI. Osteoarthritis burden is expected to continue to increase. In the population studied here, it was higher in women than in men, but this may invert by 2039. Conclusions The prevalence, incidence, and YLDs of osteoarthritis had significantly increased and may continue to increase during the next 2 decades. Prevention and treatment strategies should target women, middle-aged individuals, and the elderly.

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“…Its etiology is multifactorial, encompassing genetic, environmental, and lifestyle factors ( 4 ). Among these, body weight, particularly as measured by the body mass index (BMI), has emerged as a significant modifiable risk factor for the development of certain types of arthritis, notably osteoarthritis (OA) ( 5 ). The Global Burden of Disease study in 2017 highlighted the relevance of high BMI as a primary risk factor for the burden of OA in Brazil ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship of weight change patterns from young to middle adulthood with incident rheumatoid arthritis and osteoarthritis: a retrospective cohort study

Nan,

Zhang,

et al. 2024

Front. Endocrinol.

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BackgroundThe relationship between weight change patterns and arthritis onset, specifically rheumatoid arthritis (RA) and osteoarthritis (OA), is unclear. We examined the association between weight changes from young adulthood to midlife and arthritis onset.MethodsUsing data from NHANES 1999–2018, participants with self-reported arthritis were selected. Age at diagnosis determined arthritis onset. Weight change patterns were based on BMI at age 25 and 10 years before the survey. Patterns were categorized as stable non-obese, non-obese to obese, obese to non-obese, and stable obese. Cox regression models and restricted cubic spline (RCS) analysis were employed, calculating hazard ratios (HRs) and 95% confidence intervals (CIs) considering covariates.ResultsOut of 20,859 participants (male 11,017, 52.82%), 4922 developed arthritis over a mean 8.66-year follow-up. Compared to stable non-obese individuals, the HRs for arthritis were 1.55 (95% CI=1.45 to 1.66, P < 0.0001) for non-obese to obese and 1.74 (95% CI=1.56 to 1.95, P < 0.0001) for stable obese. Those gaining 10-20 kg had a HR of 1.33 (95% CI=1.22 to 1.46, P < 0.0001), and gains >20 kg had a HR of 1.56 (95% CI=1.42 to 1.71, P < 0.0001), compared to stable weight (change within 2.5 kg). Identical results observed for OA and RA. RCS showed a nonlinear relationship between weight change and arthritis (all P < 0.01).ConclusionsStable obesity and weight gain during adulthood increase arthritis risk. Maintaining a non-obese weight throughout adult years might reduce arthritis risk in later life.

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The burden of low back pain, rheumatoid arthritis, osteoarthritis, and gout and their respective attributable risk factors in Brazil: results of the GBD 2017 study

Cited by 8 publications

References 48 publications

Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study

Madecassic Acid Ameliorates the Progression of Osteoarthritis: An in vitro and in vivo Study

Increasing Burden of Osteoarthritis in China: Trends and Projections from the Global Burden of Disease Study 2019

Relationship of weight change patterns from young to middle adulthood with incident rheumatoid arthritis and osteoarthritis: a retrospective cohort study

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