Kidney Injury Biomarkers in Leptospirosis

Uribe-Restrepo, Pablo; Muñoz-Zanzi, Claudia; Agudelo‐Flórez, Piedad

doi:10.1590/0037-8682-0260-2022

Cited by 2 publications

(6 citation statements)

References 65 publications

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“…In a study at the Seattle hospital, they used kidney samples with kidney injury in rats and showed an increase in MCP-1 4 hours after the onset of failure [57]. Nisansala et al [24] in a cross-sectional study verified the direct relationship between the increase in MCP-1 values in the presence of AKI with leptospirosis. However, the sensitivity was lower compared to other renal biomarkers such as KIM-1.…”

Section: Monocyte Chemoattractant Protein 1 (Mcp-1)mentioning

confidence: 97%

See 1 more Smart Citation

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin-America

Osorio-Rodríguez,

Rodelo-Barrios,

Rebolledo-Maldonado

et al. 2023

Preprint

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Leptospirosis is a re-emerging zoonotic disease that has had an unprecedented impact on most health systems in the world. The spectrum of symptoms is variable and usually ranges from asymptomatic cases to severe manifestations involving multiple organ dysfunction accompanied by jaundice, hemorrhage, meningitis, and acute kidney injury that requires the need for intensive care assistance. Although early antibiotic treatment is usually effective, in severe cases it may require renal replacement therapy, invasive mechanical ventilation, vasoactive support, and invasive hemodynamic monitoring, increasing the risk of death. In Latin America, the real burden of acute kidney injury in this condition is unknown and may be underestimated due to the rapid progression of the disease, similar to other vector zoonoses, and the low coverage of diagnostic tests in primary care, especially in rural regions. Therefore, below, we review the clinical aspects and describe the scientific, clinical, and therapeutic evidence of acute kidney injury attributed to Leptospira spp. and its relevance in patients with severe leptospirosis in Latin America.

show abstract

Section: Monocyte Chemoattractant Protein 1 (Mcp-1)mentioning

confidence: 97%

“…In recent decades, studies on the use of renal biomarkers to identify premature kidney damage due to leptospirosis have expanded enormously [24]. The action of Leptospire spp.…”

Section: Diagnosismentioning

confidence: 99%

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin-America

Osorio-Rodríguez,

Rodelo-Barrios,

Rebolledo-Maldonado

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In a study at the Seattle hospital, they used kidney samples with kidney injury in rats and showed an increase in MCP-1 4 h after the onset of failure [71]. Nisansala et al [26], in a cross-sectional study, verified the direct relationship between the increase in MCP-1 values in the presence of AKI and leptospirosis. However, the sensitivity was lower compared to other renal biomarkers such as KIM-1.…”

Section: Monocyte Chemoattractant Protein 1 (Mcp-1)mentioning

confidence: 98%

“…In recent decades, studies on the use of renal biomarkers to identify premature kidney damage due to leptospirosis have increased enormously [26]. The action of Leptospira spp.…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin America

Osorio-Rodríguez,

Rodelo-Barrios,

Rebolledo-Maldonado

et al. 2024

Kidney and Dialysis

View full text Add to dashboard Cite

Leptospirosis is a re-emerging zoonotic disease that has had an unprecedented impact on most health systems in the world. The spectrum of symptoms is variable and usually ranges from asymptomatic cases to severe manifestations involving multiple organ dysfunction accompanied by jaundice, hemorrhage, meningitis, and acute kidney injury that requires the need for intensive care assistance. Although early antibiotic treatment is usually effective, in severe cases, it may require renal replacement therapy, invasive mechanical ventilation, vasoactive support, and invasive hemodynamic monitoring, increasing the risk of death. In Latin America, the real burden of acute kidney injury in this condition is unknown and may be underestimated due to the rapid progression of the disease, similar to other vector zoonoses, and the low coverage of diagnostic tests in primary care, especially in rural regions. Therefore, below, we review the clinical aspects and describe the scientific, clinical, and therapeutic evidence of acute kidney injury attributed to Leptospira spp. and its relevance in patients with severe leptospirosis in Latin America.

show abstract

Kidney Injury Biomarkers in Leptospirosis

Cited by 2 publications

References 65 publications

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin-America

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin-America

Acute Kidney Injury Associated with Severe Leptospirosis: Fatal Re-Emerging Disease in Latin America

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