Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Barbosa, Maria das Graças Vale; Ferreira, João Marcos Bemfica Barbosa; Arcanjo, Ana Ruth Lima; Santana, Rosa Amélia Gonçalves; Magalhães, Laylah Kelre Costa; Magalhães, Laise Kelma Costa; Mota, Daniel Testa; Fé, Nelson Ferreira; Monteiro, Wuelton Marcelo; Silveira, Henrique; Guerra, Jorge Augusto de Oliveira

doi:10.1590/0037-8682-0258-2013

Cited by 38 publications

(44 citation statements)

References 36 publications

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“…Mortality due to the chronic form of this protozoa has been declining over the last two decades 1 . In Brazil, Triatoma infestans is not the only vector of Trypanosoma cruzi; consequently, in some areas, especially the Amazônia Legal, there are still cases of natural transmission by extradomiciliary triatomines 20 . Transmission by blood transfusion has also been disrupted; however, there have been sporadic outbreaks of acute Chagas disease as a consequence of transmission by contaminated foods such as cane juice and açaí 1 .…”

Section: Chagas Diseasementioning

confidence: 99%

Conquistas do SUS no enfrentamento das doenças transmissíveis

Teixeira

Costa

Paixão

et al. 2018

Ciênc. saúde coletiva

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This article presents the development of the epidemiological situation of some of the major communicable diseases (CD) in Brazil, with emphasis on the interventions by the SUS and other social policies. The data and information were collected from Datasus, epidemiological newsletters from the Brazilian Ministry of Health, and scientific articles on the issue. The universalization, decentralization and expansion of the surveillance, control and prevention of CD has produced an impact on the morbidity and mortality of these diseases, mainly those which are vaccine-preventable. The emergence and re-emergence of three arboviruses, for which there are no effective control instruments, interrupted the downward trend in the morbidity profile of CD in Brazil. Other social and economic programs, which are geared to the needier sectors of the Brazilian population, have also contributed to the improvement of the analyzed health indicators. However, the universalization of access to healthcare services, as well as improvements in the scope of the surveillance of diseases and health risks, has played a key role in improving the health and quality of life of the population, as well as contributing to the process of the democratization of Brazil.

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Section: Chagas Diseasementioning

confidence: 99%

Conquistas do SUS no enfrentamento das doenças transmissíveis

Teixeira

Costa

Paixão

et al. 2018

Ciênc. saúde coletiva

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“…The other mechanisms of transmission, referred to as the secondary mechanisms 5 , such as infections caused by blood transfusion, congenital transmission, and organ transplantation, in addition to the occupational and oral exposure 6 , are dependent on the primary mechanism. Although oral transmission is accidental, it has been considered to be responsible for the recent outbreaks of Chagas disease [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Sympatry influence in the interaction of Trypanosoma cruzi with triatomine

Dworak

Araújo

Gomes

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Trypanosoma cruzi, the etiologic agent of Chagas disease, is widely distributed in nature, circulating between triatomine bugs and sylvatic mammals, and has large genetic diversity. Both the vector species and the genetic lineages of T. cruzi present a varied geographical distribution. This study aimed to verify the influence of sympatry in the interaction of T. cruzi with triatomines. Methods: The behavior of the strains PR2256 (T. cruzi II) and AM14 (T. cruzi IV) was studied in Triatoma sordida (TS) and Rhodnius robustus (RR). Eleven fifth-stage nymphs were fed by artificial xenodiagnosis with 5.6 × 10 3 blood trypomastigotes/0.1mL of each T. cruzi strain. Every 20 days, their excreta were examined for up to 100 days, and every 30 days, the intestinal content was examined for up to 120 days, by parasitological (fresh examination and differential count with Giemsa-stained smears) and molecular (PCR) methods. Rates of infectivity, metacyclogenesis and mortality, and mean number of parasites per insect and of excreted parasites were determined. Results: Sympatric groups RR+AM14 and TS+PR2256 showed higher values of the four parameters, except for mortality rate, which was higher (27.3%) in the TS+AM14 group. General infectivity was 72.7%, which was mainly proven by PCR, showing the following decreasing order: RR+AM14 (100%), TS+PR2256 (81.8%), RR+PR2256 (72.7%) and TS+AM14 (36.4%). Conclusions: Our working hypothesis was confirmed once higher infectivity and vector capacity (flagellate production and elimination of infective metacyclic forms) were recorded in the groups that contained sympatric T. cruzi lineages and triatomine species.

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“…A study by Lenzi [10] demonstrated the relationship between the disseminated form of infection, tissue damage in the acute phase and the presence of the parasite in the tissue. Other authors have also described the relationship between T. cruzi parasitism and acute infection in other organs, such as the kidney and intestines [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Renal Disfunction in Chagas Disease

Miguel¹,

Filho²,

Mendes³

et al. 2017

J Bacteriol Parasitol

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Background: Chagas' disease has a wide distribution in South America, having several forms of transmission. The disease's evolution varies according to the parasite/host relationship, presenting diversified progression through the acute, indeterminate and chronic forms. In the cardiac form, there are several clinical and laboratory alterations due to the involvement of several organs, including the kidneys. Actually, a lot of mechanisms are employed for the control and detection of renal damage. It has been proven that before the cardiac inflammatory changes were established, alterations in renal function could be observed due to elevated levels of urea, creatinine and other alterations compatible with the clinical picture of uremia. As well it was possible to verify an anemic state in laboratory animals, thus, it could be a condition known as cardio-anemic-renal syndrome described in patients with heart failure. Although there are studies correlating clinical and laboratory findings of renal dysfunction in Chagas' disease, there is still a need to elucidate some pathways of interaction between chagasic physiopathogeny and renal function.

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Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Cited by 38 publications

References 36 publications

Conquistas do SUS no enfrentamento das doenças transmissíveis

Conquistas do SUS no enfrentamento das doenças transmissíveis

Sympatry influence in the interaction of Trypanosoma cruzi with triatomine

Renal Disfunction in Chagas Disease

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