Dengue seroprevalence and its socioeconomic determinants in Faisalabad, Pakistan: a cross-sectional study

Raza, Faisal; Ashraf, Sajjad; Hasnain, Shahida; Ahmad, Jameel; Iqbal, Mazhar

doi:10.1590/0037-8682-0246-2017

Cited by 7 publications

(10 citation statements)

References 14 publications

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“…Thus, inadequate storage of water, inadequate sewage disposal and insufficient urban garbage collection, in addition to little or no practical action aimed at vector prevention, favor DENV transmission. 34,36,[38][39][40][41][42] Nonetheless, in the present study, there were no statistically significant associations for any of the health variables analyzed, as was also previously observed in studies conducted in the city of Belo Horizonte (Minas Gerais) in 2008 and in the city of Caraguatatuba (São Paulo) in 2018. 40,43 Directly associations with risks of DENV infection were observed with regard to nonuse of protective measures such as mosquito nets (26.2%), presence of mosquito breeding sites (28.0%) and visits by endemic disease combat agents (31.1%) to homes at intervals of two to four months.…”

Section: The Seroprevalence Profile Of Dengue Virus Infection (Denv)supporting

confidence: 83%

Recent dengue virus infection: epidemiological survey on risk factors associated with infection in a medium-sized city in Mato Grosso

Ferreira¹,

Atanaka²,

Espinosa³

et al. 2022

Sao Paulo Med. J.

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BACKGROUND: Dengue is considered to be the most important arbovirus worldwide, with important complications that increase its lethality. In Brazil, an endemic country, the disease reaches significant incidence levels, with occurrences of serious cases and high costs of hospitalizations for its treatment. OBJECTIVE: To analyze risk factors among individuals with recent histories of dengue infection in a medium-sized city in Mato Grosso. DESIGN AND SETTING: Descriptive cross-sectional study, of epidemiological-survey type, conducted among the urban population of a city located in mid-northern Mato Grosso. METHODS: A seroepidemiological survey using questionnaires and collection of biological material was conducted among 596 adults aged ≥ 18 years who had been selected through a cluster sampling process. Positive dengue cases were those with positive results from anti-dengue immunoassays (ELISA). Statistical analyses with descriptive and inferential techniques were used, with 95% confidence intervals and a 5% significance level. RESULTS:The seroepidemiological profile of the study participants was predominantly female, with ages between 18 and 39 years, self-declared non-white race/color, not more than eight years of education and not living with a companion. Among the sanitary factors analyzed, the following were risk factors for dengue virus infection: no running water at home; no water supply from the public piped network; no waste from drains or toilets sent to the sewage network; endemic disease combat agents visiting the home; and presence of mosquito breeding sites at home. CONCLUSION: Low schooling levels and previous dengue virus infection were associated with current dengue virus infection.

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Section: The Seroprevalence Profile Of Dengue Virus Infection (Denv)supporting

confidence: 83%

Recent dengue virus infection: epidemiological survey on risk factors associated with infection in a medium-sized city in Mato Grosso

Ferreira¹,

Atanaka²,

Espinosa³

et al. 2022

Sao Paulo Med. J.

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“…A study conducted in Faisalabad, Pakistan showed that socioeconomic disparities in the community make some groups more vulnerable to dengue infection [23]. According to this report, 22.9% of the surveyed participants (4.8% positive for IgM and 18.1% positive for IgG) were dengue positive.…”

Section: Discussionmentioning

confidence: 95%

Seroprevalence, risk factors and impact of dengue fever/hepatitis B coinfection on liver function parameters in Cameroonian patients

Galani¹,

Babai²,

Ngakou³

2022

ceh

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Introduction: Dengue and hepatitis B are viral infections endemic to tropical areas with liver consequences. However, coinfection cases have been poorly documented worldwide and especially on the African continent. This study aimed at analysing the seroepidemiology of dengue-hepatitis B co-infection in patients recruited at the Regional Hospital of Ngaoundere (Cameroon). Material and methods: A cross-sectional study was conducted among 225 patients, aged 15-55 years, enrolled at the Laboratory service of Ngaoundere Regional Hospital from 25 September to 10 December 2021. HBsAg and dengue infection were diagnosed using the serological rapid tests. Part of the blood samples was used to quantify lipid profile and liver function parameters. Results: Of the 225 patients recruited, 22.22% (50) tested positive for hepatitis B and 18.18% (38/202) were positive for dengue fever, with a dengue-hepatitis B coinfection rate of 4.95% (10/202). Coinfected patients were not significantly associated with liver injury compared to monoinfected patients. However, they displayed a higher risk of presenting abnormal γ-glutamyltransferase (γ-GT) (RR = 1.74, 90% vs. 51.51%) and alanine aminotransferase (ALT) values (RR = 1.52, 60% vs. 39.39%) compared to the monoinfected group. Also, there was no difference in total and direct bilirubin between patient groups. The mean triglyceride and low-density lipoprotein (LDL) cholesterol levels and coronary heart index values were higher in the coinfected group than in the monoinfected group, but without significance. Conclusions: Taken altogether, these findings suggest that the presence of hepatitis B in dengue patients may slightly affect the liver's metabolic functions. Clinical surveillance of this coinfection is therefore required to avoid further liver complications.

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“…Low white blood cells were the key in the early dengue diagnosis. Infected mosquito's bite signs usually last for two to seven days, following incubations for 4 -10 days (25,26). Moreover, 10105 (78.6%) persons were suspected during the last five years, suggesting that severe dengue is a life-threatening complication causing plasma leak and fluid accumulation, respiratory distress, severe bleeding, or impairment (27).…”

Section: Discussionmentioning

confidence: 99%

Molecular and Haematological Analysis of Dengue Virus-3 Among Children in Lahore, Pakistan

Kashif

Afzal

Zeshan

et al. 2021

Jundishapur J Microbiol

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Background: Dengue virus (DENV) is an RNA virus belonging to the family Flaviviridae of the genus Flavivirus with worldwide distribution. Dengue fever is caused by any of four closely-related serotypes DENV, an emerging pandemic-prone viral disease in many regions of the world. Objectives: The present study aimed to determine the prevalence of dengue virus genotypes and serotypes in children aged below 15 years in Lahore, Pakistan. Methods: In this study, 112 serum samples were collected from clinically suspected dengue fever patients from March 2017 to December 2018 at different tertiary care hospitals in Lahore, Pakistan. Regarding the patients’ age, the samples were divided into four groups from A to D (i.e., 0 - 1, 1 - 5, 5 - 10, and 10 - 15 years of age). Rapid immuno-chromatography (ICT) test was conducted on the collected serum samples, followed by quantitative RT-PCR for serotype of dengue virus. Results: Out of 112 samples, 34 samples were diagnosed as DENV positive by the rapid ICT screening method. No virus was detected in groups A and B, while three samples were positive in group C (1 boy and two girls), and 31 samples (23 boys and 8 girls) were positive in group D. The results of quantitative RT-PCR exclusively showed DEN-3 serotype in all the ICT positive samples. The results indicated that the prevalence of DEN-3 serotype in children was 100%, indicating that DEN-3 serotype might cause severe epidemics in the future in Lahore, Pakistan. Hematological analysis revealed an increase in hematocrits in 41.1% dengue-positive cases. Leucopenia was prominent in 79.4% of the cases, while Thrombocytopenia was reported in 70.5% of the participants. The biochemical analysis also indicated an increase in liver enzymes in patients (ALT 88%, AST 79%), while the lower levels of cholesterol (69 %) and serum albumin (25%) were also observed. Conclusions: Dengue virus spreads and grows quickly worldwide over a highly short time interval. Dengue fever claims for a significant number of lives. This study would help individuals know about the status of laboratory parameters in dengue fever and detect how to overcome the prevalence of Dengue virus.

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Dengue seroprevalence and its socioeconomic determinants in Faisalabad, Pakistan: a cross-sectional study

Abstract: An integrated approach is required to control the menace through vector control strategies and improvement of socioeconomic conditions.

Cited by 7 publications

References 14 publications

Recent dengue virus infection: epidemiological survey on risk factors associated with infection in a medium-sized city in Mato Grosso

Recent dengue virus infection: epidemiological survey on risk factors associated with infection in a medium-sized city in Mato Grosso

Seroprevalence, risk factors and impact of dengue fever/hepatitis B coinfection on liver function parameters in Cameroonian patients

Molecular and Haematological Analysis of Dengue Virus-3 Among Children in Lahore, Pakistan

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