Schistosomiasis in Southern Brazil 17 years after the confirmation of the first autochthonous case

Martins, Demetrius da Silva; Xavier, Mariana Fabris; Masiero, Franciéle de Souza; Cordeiro, Juliana; Thyssen, Patrícia Jacqueline

doi:10.1590/0037-8682-0240-2014

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Echazú et al (2015) described inadequate sanitation and unsafe water supply as risk factors for parasitic human infection. In Brazil, this species is a natural host of Schistosoma mansoni, which causes schisostomiasis and affects approximately 6 million people (Martins et al 2015). Paraense (2005) recorded this species in Jujuy province and gave the city of San Salvador de Jujuy as a generalized locality without specifying an exact collection site.…”

Section: Discussionmentioning

confidence: 99%

An annotated checklist of Planorbinae (Heterobranchia, Hygrophila, Planorbidae) from northwestern Argentina

Ovando¹,

Marchi²

2021

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The family Planorbidae comprises freshwater gastropods with planispiral, spiral and limpet-shaped shells. Subfamily Planorbinae sensu stricto, has a richness of almost 300 species, with some of the main genera being Biomphalaria Preston, 1910 and Drepanotrema Fischer & Crosse, 1880. Some Biomphalaria species are of concern to human health as they are intermediate hosts of blood flukes in Latin America. In Argentina, the family Planorbidae is represented by 15 species in four genera. In Northern Argentina (NOA region), records of the family are scarce, and most of them are a result of occasional collecting. We provide an updated checklist of Planorbinae in NOA resulting from fieldwork, material in malacological collections, and data in the literature. Nine species occur in the area: four species of Biomphalaria and five of Drepanotrema. Among Biomphalaria species, we recorded Biomphalaria straminea (Dunker, 1848), which is considered a natural host of the blood fluke Schistostoma mansoni Sambon, 1907, for first time in Salta province; the known geographic distribution of B. straminea is extended in the country.

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Section: Discussionmentioning

confidence: 99%

An annotated checklist of Planorbinae (Heterobranchia, Hygrophila, Planorbidae) from northwestern Argentina

Ovando¹,

Marchi²

2021

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“…The WHO list was chosen as a reference to this study because it is applicable worldwide and widely considered as the main reference about NTD. The identified diseases, classified as being possibly prevalent, were: Buruli ulcer [1,8], schistosomiasis [1,[9][10][11][12], trachoma [1,10,12,13], echinococcosis [1,10,14,15], rabies [1,10,16,17], and foodborne trematodiases [1,18]; and those classified as prevalent were: leprosy [1,10,12,15,16,19], Chagas' disease [1,9,10,15,16], leishmaniasis [1,10,15,16,19], taeniasis and cysticercosis [1,12,20,21], soil-transmitted helminthiases [1,9,12,21,22], and dengue [1,…”

Section: Introductionmentioning

confidence: 99%

Are the neglected tropical diseases under control in the tri-border region between Brazil, Argentina, and Paraguay?

Oliveira

Arcêncio

Arcoverde

et al. 2022

J Infect Dev Ctries

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Introduction: Implementation of prevention and control measures for communicable diseases in border regions can be challenging and lead to inefficient attempts to control them. We describe evidences on the strengths, weaknesses, opportunities and challenges regarding implementation of health interventions for control, prevention and treatment of selected neglected tropical diseases (NTD), a group of transmissible diseases typically prevalent in tropical countries and vulnerable populations, in the tri-border between Brazil, Argentina, and Paraguay. Methodology: A systematic literature review of observational and experimental studies was conducted, using PubMed and Bireme databases. Eligibility criteria were location (tri-border area) and subject (health interventions). Results: Of a total of 595 references identified, 34 studies were included (18 pertaining to leishmaniasis, 11 to dengue, 2 to leprosy, 2 to soil-transmitted helminthiases and 1 to Chagas’ disease), with an inclusion rate of 6.4%. The main strengths were the similarity of health interventions between countries and easiness of mobility and communication flows. The main weaknesses were access to rural areas and discrepancies in the number of studies between countries. As for opportunities, we identified increased tourism, economic development and recent increasing research in this field. The main challenges were the absence of studies regarding other prevalent NTD in the region and movement of goods, animals and people across borders. Conclusions: Although epidemiological studies are still needed to better understand and assess the prevalence of NTD in the area, mainly in Paraguay, these findings can inform decision-makers and health managers to plan a common strategy to address NTD.

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“…Transmission cases were reported in 78 countries with 52 out of these considered endemic regions [3]. This disease is prevalent in poor and rural areas that lack access to safe drinking water and sanitation [4].…”

Section: Introductionmentioning

confidence: 99%

Structural basis for the function and inhibition of dihydroorotate dehydrogenase from Schistosoma mansoni

et al. 2020

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Schistosomiasis is a serious public health problem, prevalent in tropical and subtropical areas, especially in poor communities without access to safe drinking water and adequate sanitation. Transmission has been reported in 78 countries, and its control depends on a single drug, praziquantel, which has been used over the past 30 years. Our work is focused on exploiting target‐based drug discovery strategies to develop new therapeutics to treat schistosomiasis. In particular, we are interested in evaluating the enzyme dihydroorotate dehydrogenase (DHODH) as a drug target. DHODH is a flavoenzyme that catalyzes the stereospecific oxidation of (S)‐dihydroorotate (DHO) to orotate during the fourth and only redox step of the de novo pyrimidine nucleotide biosynthetic pathway. Previously, we identified atovaquone, used in the treatment of malaria, and its analogues, as potent and selective inhibitors against Schistosoma mansoni DHODH (SmDHODH). In the present article, we report the first crystal structure of SmDHODH in complex with the atovaquone analogue inhibitor 2‐((4‐fluorophenyl)amino)‐3‐hydroxynaphthalene‐1,4‐dione (QLA). We discuss three major findings: (a) the open conformation of the active site loop and the unveiling of a novel transient druggable pocket for class 2 DHODHs; (b) the presence of a protuberant domain, only present in Schistosoma spp DHODHs, that was found to control and modulate the dynamics of the inhibitor binding site; (c) a detailed description of an unexpected binding mode for the atovaquone analogue to SmDHODH. Our findings contribute to the understanding of the catalytic mechanism performed by class 2 DHODHs and provide the molecular basis for structure‐guided design of SmDHODH inhibitors. Database The structural data are available in Protein Data Bank (PDB) database under the accession code number https://www.rcsb.org/structure/6UY4.

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Schistosomiasis in Southern Brazil 17 years after the confirmation of the first autochthonous case

Cited by 8 publications

References 9 publications

An annotated checklist of Planorbinae (Heterobranchia, Hygrophila, Planorbidae) from northwestern Argentina

An annotated checklist of Planorbinae (Heterobranchia, Hygrophila, Planorbidae) from northwestern Argentina

Are the neglected tropical diseases under control in the tri-border region between Brazil, Argentina, and Paraguay?

Structural basis for the function and inhibition of dihydroorotate dehydrogenase from Schistosoma mansoni

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