Clinical and serological outcomes with different surgical approaches for human hepatic hydatidosis

Abdelraouf, Amr; El-Aal, Amany Ahmed Abd; Shoeib, Eman Y.; Attia, Samar S.; Hanafy, Nihal A.; Hassani, Mehdi El; Shoman, Soheir

doi:10.1590/0037-8682-0223-2015

Cited by 18 publications

(19 citation statements)

References 31 publications

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“…In the study, ELISA was reactive in 62 (28%) USGpositive HD cases, which is in accordance with a study from Chandigarh in North India 17 but in contrast to studies from China and Egypt where seropositivity was higher. 18,19 On the other hand, FNAC in the study was positive in 16 (7.2%) cases, which is similar to two other studies from Chandigarh. 20,21 In the study, Echinococcus IgG reactive cases were seen more in the age group of 1 to 20 years with a male preponderance, whereas liver mass lesions on USG were predominant in the age group of 51-60 years.…”

Section: Discussionsupporting

confidence: 89%

Comparative Evaluation of Echinococcus Serology with Cytology for the Diagnosis of Hepatic Hydatid Disease

et al. 2020

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Objectives The purpose of this study is to determine the diagnostic efficacy of enzyme-linked immunosorbent assay (ELISA) in radiologically confirmed liver mass lesions for the diagnosis of hepatic hydatid disease (HHD) and to compare the diagnostic performance of ELISA with fine needle aspiration cytology (FNAC) (taken as standard) for HHD diagnosis. Materials and Methods This retrospective study included blood samples of 223 patients with radiologically confirmed liver mass lesions in which immunoglobulin G (IgG) anti-Echinococcus antibodies were tested using a commercial IgG ELISA (RIDASCREEN, R-Biopharm AG, Darmstadt, Germany). Results of ELISA, ultrasonography, FNAC, and liver function tests were obtained from the hospital information system. ELISA results were compared with those of FNAC to analyze the diagnostic efficacy of ELISA for HHD diagnosis. Statistical Analysis Comparison of the results obtained from ELISA was performed with respect to FNAC results (taken as standard) to analyze the diagnostic efficacy of ELISA for HHD detection. Data has been represented as median (range) or in frequencies. Wilson score was used to assess 95% confidence interval of diagnostic parameters. The analysis was performed using SPSS Version 22.0 (IBM Corp.) and Open Epi (version 3.01). Results Out of 223 cases with liver mass lesions, Echinococcus IgG was reactive in 62 (28%) cases and FNAC was positive in 16 (7.2%) cases. Since two cases were FNAC-positive but IgG-nonreactive, total HHD cases were 64 (28.7%). Echinococcus IgG reactive cases were seen more in the extremes of age group, that is, 1 to 10 years and 81 to 90 years. Taking FNAC as the standard, the sensitivity, specificity, positive predictive value, and negative predictive value of ELISA were 87.5, 76.8, 22.6, and 98.7%, respectively. Cytology-positive cases demonstrated a mean ELISA optical density/cut-off (OD/CO) of 4.2 ± 3 standard deviation. Conclusion ELISA in radiologically confirmed liver mass cases is highly sensitive in detecting HHD and hence should be used along with ultrasonography for the screening of HHD followed by confirmation with cytology even in cases with a higher OD/CO of ELISA.

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Section: Discussionsupporting

confidence: 89%

Comparative Evaluation of Echinococcus Serology with Cytology for the Diagnosis of Hepatic Hydatid Disease

et al. 2020

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“…In our patient, symptoms started to be noticed only when the mass became significantly large in size. Ultrasonography of the abdomen is the most common first-line radiological investigation performed to determine the organ of origin and to characterize the hydatid cyst (dimension, vitality) [ 9 ]. Computed tomography (CT) is also a modality of choice in affected patients since it allows imaging of the entire abdomen and pelvis, gives more precise information regarding size, location, adherence to neighbouring structures.…”

Section: Discussionmentioning

confidence: 99%

Primary hydatid cyst of the small intestine masquerading as intestinal duplication

Tlili¹,

Hellal²,

Abdallah³

et al. 2020

PAMJ

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Hydatid disease or hydatidosis is a worldwide zoonosis disease caused by the tapeworm of Echinococcus granulosus and still widely endemic in Tunisia especially in rural areas where the sheep-dog cycle is dominant. It is an important public health problem in the pediatric age group causing significant morbidity and mortality. We report a case of primary hydatid cyst of the small intestine in a child and we want to highlight the difficulty that we meet in the diagnosis despite the contribution of imaging.

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“…In the management of CE disease, recurrence remains one of the major problems associated with the surgical removal of primary cysts [ 40 , 41 ]. Recurrence is defined as the appearance of a new growing cyst, undetected by imagery before the first surgery or by the surgeon during the first procedure [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Microsatellite Investigations of Multiple Echinococcus granulosus Sensu Stricto Cysts in Single Hosts Reveal Different Patterns of Infection Events between Livestock and Humans

M’rad

Oudni-M’rad

Bastid³

et al. 2020

Pathogens

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Cystic echinococcosis (CE) caused by the cestode Echinococcus granulosus sensu lato (s.l.) is a worldwide zoonosis and E. granulosus sensu stricto (s.s.) is the most common species associated with animal and human diseases. The objective of this study was to obtain a better understanding of CE infection in livestock and humans from very low and high endemic areas—France and Tunisia—by studying the genetic diversity of E. granulosus s.s. at the intra-individual host level. This genetic diversity was studied using EgSca6 and EgSca11 microsatellite profiles in 93 sheep from France and Tunisia, and in 12 cattle and 31 children from Tunisia only, all presenting multiple CE cysts (2 to 10 cysts). Overall, 96% of sheep, 92% of cattle, and 48% of children had at least two cysts with different microsatellite profiles. Inversely, 35% of sheep, 17% of cattle, and 65% of children had at least two cysts with the same microsatellite profile. The genotyping results for the CE samples highlight high and similar genetic diversity in France and Tunisia, suggesting that the probability of being successively infected by CE of the same microsatellite profile was rare in both countries. Therefore, our results suggest that in rare cases, several eggs of the same microsatellite profile, from two to seven in our data, can be ingested simultaneously in a single infection event and develop into several cysts in livestock and children. They also indicate that multiple infection events are frequent in livestock, even in a low endemic country such as France, and are less frequent but not negligible in children in a high endemic country such as Tunisia. Moreover, this is the first time that genetic evidence of secondary CE has been found. Further studies are needed to better assess the pattern of infection events in livestock and humans, especially by studying the genetic diversity of adult worms in definitive hosts.

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Clinical and serological outcomes with different surgical approaches for human hepatic hydatidosis

Cited by 18 publications

References 31 publications

Comparative Evaluation of Echinococcus Serology with Cytology for the Diagnosis of Hepatic Hydatid Disease

Comparative Evaluation of Echinococcus Serology with Cytology for the Diagnosis of Hepatic Hydatid Disease

Primary hydatid cyst of the small intestine masquerading as intestinal duplication

Microsatellite Investigations of Multiple Echinococcus granulosus Sensu Stricto Cysts in Single Hosts Reveal Different Patterns of Infection Events between Livestock and Humans

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