Serious disease outbreaks caused by viruses transmitted by Aedes aegypti in Brazil

Figueiredo, Luíz Tadeu Moraes

doi:10.1590/0037-8682-0209-2016

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…The main reason for this increase in production is probably related to the increased number of reported dengue outbreaks in endemic regions. 76 The impact of the COVID-19 pandemic on research output can also be seen in the decrease in the number of publications between 2019 and 2020. The reduction in the number of publications can be attributed to a change of focus to address the pandemic.…”

Section: Distribution Of Published Work On the Dengue Virus Among Blo...mentioning

confidence: 99%

Dengue Virus and Blood Safety: A Mini-Review of Research Publications

Mulakoli

Gachara

Ndombi

et al. 2023

EASci

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The growing demand for donated whole blood and blood products to save lives has both health benefits and health risks for blood recipients at the same time. Dengue virus, a re-emerging viral disease poses a threat to blood safety, and it has spread to over 128 countries in the world. Several studies have documented transfusion-transmitted (TT) dengue, with the first cases being reported in China in 2002 and Singapore in 2008. To understand the magnitude and broader picture of the dengue virus and blood safety, we conducted a mini-review of published literature from the Scopus database. The review focused on the number of publications related to the dengue virus among blood donors. Using keywords ‘Dengue virus’ AND ‘Blood safety’, ‘ Dengue virus’ AND ‘Blood donors’ and ‘Emerging infectious diseases’ AND “Blood safety” were used to extract data from the Scopus database which was downloaded as a CSV Excel file covering a period 2004 to 2021. This was followed by a data-cleaning exercise and a descriptive analysis to generate the frequency of the number of publications. Most studies, as can be seen in the review, were concentrated in tropical regions of the world. Globally, South America and the Asian regions had the largest number of publications; while at the country level, Brazil and India had the highest number. More research output was witnessed during the years 2014 and 2018. The regions that experienced more frequent outbreaks of the disease, with the exception Africa, published most of the research work. Therefore, much more research work is needed to protect the safety of blood donors in Africa.

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Section: Distribution Of Published Work On the Dengue Virus Among Blo...mentioning

confidence: 99%

Dengue Virus and Blood Safety: A Mini-Review of Research Publications

Mulakoli

Gachara

Ndombi

et al. 2023

EASci

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“…and Aedes sp. act as vectors of MAYV in rural and urban areas, respectively [8]. A recent nding shows the potential for MAYV transmission by the urban vectors Aedes aegypti and Aedes albopictus thus contributing to the classi cation of the MAYV as an emerging virus, having a potential for inclusion in the urban cycle, as occurred more recently with the Chikungunya virus [9][10][11].…”

Section: Mayaro Virus (Mayv) Belongs To the Togaviridae Family Alphamentioning

confidence: 99%

Virucidal and Antiviral Activity of Extract of Punica Granatum Cultivated in Brazil

Salles¹,

Meneses²,

Caldas³

et al. 2021

Preprint

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Background: The arthropod-borne Mayaro virus (MAYV) causes ‘Mayaro fever’, a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America. Recently, MAYV has attracted attention due to its likely urbanization. Currently, there are no licensed drugs against most mosquito-transmitted viruses. Punica granatum (pomegranate) fruits cultivated in Brazil were submitted to a phytochemical investigation for the identification and isolation of antiviral compounds. In the present study we studied the antiviral activity of pomegranate extracts in Vero cells infected with Mayaro virus. Methods: The Ethanol extract and Punicalagin of Pomegranate were extracted solely of the shell and purified by chromatographic fractionation and chemically identified using spectroscopic techniques. Cytotoxicity of purified compounds was measured by the dye-uptake assay while their antiviral activity was evaluated by a virus yield inhibition assay.Results: Pomegranate ethanol extract (CC50 = 588.9, IC50 = 12.3) and a fraction containing punicalagin as major compound (CC50 = 441.5, IC50 = 28.2) were shown to have antiviral activity (SI 49 and 16, respectively) against Mayaro virus, an alphavirus. Immunofluorescence analysis showed the virucidal effect of Pomegranate extract and Transmission Electron Microscopy (TEM) revealed damage in viral particles treated with this extract. Conclusions: The P. granatum extract is a promising source of antiviral compounds against the alphavirus MAYV and are excellent candidates for future studies with other enveloped RNA viruses.

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“…and Aedes spp. act as vectors of MAYV in rural and urban areas, respectively [ 8 ]. A recent finding shows the potential for MAYV transmission by the urban vectors Aedes aegypti and Aedes albopictus , thus contributing to the classification of the MAYV as an emerging virus, with the potential for inclusion in the urban cycle, as has occurred more recently with the Chikungunya virus [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Virucidal and antiviral activities of pomegranate (Punica granatum) extract against the mosquito-borne Mayaro virus

et al. 2021

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Background The arthropod-borne Mayaro virus (MAYV) causes “Mayaro fever,” a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America. Recently, MAYV has attracted attention due to its likely urbanization. There are currently no licensed drugs against most mosquito-transmitted viruses. Punica granatum (pomegranate) fruits cultivated in Brazil have been subjected to phytochemical investigation for the identification and isolation of antiviral compounds. In the present study, we explored the antiviral activity of pomegranate extracts in Vero cells infected with Mayaro virus. Methods The ethanol extract and punicalagin of pomegranate were extracted solely from the shell and purified by chromatographic fractionation, and were chemically identified using spectroscopic techniques. The cytotoxicity of the purified compounds was measured by the dye uptake assay, while their antiviral activity was evaluated by a virus yield inhibition assay. Results Pomegranate ethanol extract (CC50 = 588.9, IC50 = 12.3) and a fraction containing punicalagin as major compound (CC50 = 441.5, IC50 = 28.2) were shown to have antiviral activity (SI 49 and 16, respectively) against Mayaro virus, an alphavirus. Immunofluorescence analysis showed the virucidal effect of pomegranate extract, and transmission electron microscopy (TEM) revealed damage in viral particles treated with this extract. Conclusions The P. granatum extract is a promising source of antiviral compounds against the alphavirus MAYV and represents an excellent candidate for future studies with other enveloped RNA viruses. Graphical abstract

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Serious disease outbreaks caused by viruses transmitted by Aedes aegypti in Brazil

Cited by 6 publications

References 9 publications

Dengue Virus and Blood Safety: A Mini-Review of Research Publications

Dengue Virus and Blood Safety: A Mini-Review of Research Publications

Virucidal and Antiviral Activity of Extract of Punica Granatum Cultivated in Brazil

Virucidal and antiviral activities of pomegranate (Punica granatum) extract against the mosquito-borne Mayaro virus

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