A case of chikungunya virus disease presenting with remarkable acute arthritis of a previously damaged finger joint

Eyer-Silva, Walter de Araújo; Neto, Henrique de Barros Pinto; Silva, Guilherme Almeida Rosa da; Ferry, Fernando Raphael de Almeida

doi:10.1590/0037-8682-0204-2016

Cited by 3 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Weakness in the hands during acute illness was highly associated with the risk of persistent arthralgia in our study participants. Previous studies of chronic CHIKV disease patients have demonstrated joint space narrowing in the distal joints upon radiographic imaging [ 43–45 ] and remarkable persistent arthritis of these joints [ 46 ], suggesting that disseminated infection and inflammation during acute illness increases the likelihood of persistent arthralgia symptoms. Clinical management of acute symptoms, particularly inflammation, and the minimization of acute disease duration could reduce the incidence, morbidity, and economic impact of chronic CHIKV disease.…”

Section: Discussionmentioning

confidence: 99%

The Identification of Risk Factors for Chronic Chikungunya Arthralgia in Grenada, West Indies: A Cross-Sectional Cohort Study

Heath

Lowther

Noël

et al. 2018

Open Forum Infectious Diseases

View full text Add to dashboard Cite

BackgroundChikungunya virus (CHIKV) is a re-emerging arboviral pathogen. In 2014, an explosive CHIKV outbreak occurred in Grenada, West Indies, infecting approximately 60% of the population. In approximately 50% of cases, CHIKV infection transitions to painful arthralgia that can persist for years. Elucidation of the risk factors for chronic disease is imperative to the development of effective risk management strategies and specific therapeutics.MethodsWe conducted a cross-sectional study of 240 people who were tested for CHIKV during the outbreak. We administered questionnaires to examine demographic, behavioral, psychological, social, and environmental factors to identify associations with chronic disease. Physical examinations were performed and persistent symptoms were recorded.ResultsEthnicity and socioeconomic status were not associated with risk of chronic joint pain. Female sex increased risk, and age was demonstrated to be predictive of chronic CHIKV sequelae. Mosquito avoidance behaviors did not reduce risk. Patients suffering joint pains, generalized body ache, and weakness in the extremities during acute infection were more likely to develop chronic arthralgia, and an increased duration of acute disease also increased risk.ConclusionsThese data demonstrate that chronic CHIKV affects people across the ethnic and socioeconomic spectrum, and it is not reduced by vector avoidance activity. Increased duration of acute symptoms, in particular acute joint pain, was strongly correlated with the risk of persistent arthralgia, thus effective clinical management of acute CHIKV disease could reduce burden of chronic CHIKV.

show abstract

Section: Discussionmentioning

confidence: 99%

The Identification of Risk Factors for Chronic Chikungunya Arthralgia in Grenada, West Indies: A Cross-Sectional Cohort Study

Heath

Lowther

Noël

et al. 2018

Open Forum Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…The case reports and case series found nonspecific but important joint alterations. One case report by Eyer-Silva et al 17 described a 36-year-old man infected with CHIKV who developed severe acute arthritis in a finger joint previously damaged by trauma, confirmed on radiography.…”

Section: Resultsmentioning

confidence: 99%

Bone erosions and joint damage caused by chikungunya virus: a systematic review

Amaral,

Taylor,

Schoen

2024

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Background: Chikungunya fever is an emerging global infection transmitted by Aedes mosquitoes that manifests as an acute febrile illness with joint pain and can lead to chronic arthritis. The mechanism underlying chronic joint damage remains unclear; however, chronic chikungunya arthritis shares similarities with rheumatoid arthritis. Disease-modifying antirheumatic drugs have revolutionized rheumatoid arthritis treatment by preventing joint damage. However, the role of these therapies in chronic chikungunya arthritis has not been determined. We conducted a systematic review to evaluate the burden of joint structural damage in chronic chikungunya arthritis to help to define the role of disease-modifying therapy in this disease. Methods: This systematic review included retrospective and prospective studies, trials, and case reports evaluating joint damage caused by chikungunya virus. Various databases were searched without any date or language restrictions. Study selection was conducted independently by two researchers, and data were extracted from the articles selected. Results: A total of 108 studies were initially evaluated, with 8 meeting the inclusion criteria. Longitudinal studies have reported persistent joint pain from chikungunya infection and the progression of radiographic joint damage up to 13 years post-infection. Joint imaging revealed synovial inflammation, bone erosion, and cartilage destruction in patients with chronic chikungunya arthritis. Conclusions: Few studies have addressed chikungunya-induced joint damage, limiting our understanding of chronic chikungunya arthritis. Nevertheless, chronic chikungunya arthritis has similarities to rheumatoid arthritis. The success of early disease-modifying antirheumatic drug therapy in rheumatoid arthritis underscores the need for comprehensive research on its role in chikungunya arthritis.

show abstract

“…( 16) Global warming/climate change, globalization with signi cant increase in international travels, and adaptation of virus to new vectors has also increased the vector susceptibility and transmission capacity. (13,19) CHIKV most probably rst emerged as a human pathogen in the 18th century, but currently has been identi ed in nearly 80 countries across 5 continents. (10) Most epidemics of chikungunya fever occurred in tropical or subtropical areas; Eritrea's subtropical climate is suitable for Aedes mosquitoes and the transmission of mosquito-borne diseases, such as CHIKF.…”

Section: Discussionmentioning

confidence: 99%

“…(2,(10)(11)(12) CHIKV, like the dengue and zika virus, are commonly classi ed as arthritogenic viruses as these viruses cause musculoskeletal in ammatory disease in humans. (13) Upon infection, CHIKV has an incubation period of 3-7 days, but may last as long as fourteen days. (6, 14) Seroprevalence studies have demonstrated that 30-40% of CHIKV infected individuals can be asymptomatic, but the majority (60-80%) of infected individuals are symptomatic.…”

Section: Introductionmentioning

confidence: 99%

“…(14,15) After the incubation period, sudden onset of highgrade fever, polyarthralgia, headache, myalgia, and transient maculopapular skin rash commonly develop. (13,14) In addition, swollen joints, tenosynovitis, vomiting, and nausea have also been observed. (10) Chikungunya fever is rarely fatal with an acute crippling phase that lasts 1-2 weeks followed by convalescence.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute clinical features and persistence of joint pain in probable cases of Chikungunya Fever in Eritrea

Frezgi,

Berhane,

Ghebrewelde

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Chikungunya fever is a mosquito-borne viral illness that has re-emerged as an important global concern. Persistent arthralgia following chikungunya fever is common and requires advanced pharmacological interventions as pain does not respond well to analgesics. Objective The study aimed to describe the acute clinical features of probable cases of chikungunya fever and risk factors associated with the persistence of joint pain. Methods A prospective, descriptive cohort study was conducted on probable cases of chikungunya fever from October 2018 to March 2019 following the chikungunya outbreak of October 2018 in the Tesseney subzone of Eritrea. Results A total of 203 probable cases of chikungunya fever were enrolled, majority being males (68%) with a mean age of 39.2 years. The acute phase symptoms include the triad of polyarthralgia (97%), fever (96.1%), and skin rash (56.7%). Commonly affected joint sites were the wrist (59.4%) and interphalangeal joints of the hands (56.9%). Fever had a mean duration of 4.1 ± 3 days, while headache had a mean duration of 3.8 ± 3 days. Skin rash was maculopapular which was pruritic (85.2%) with common involved sites were the hands (71%) and trunk (46.5%). Complete blood count during the initial visit showed lymphocytosis (64.5%) and granulocytopenia (43.3%). Joint pain persisted at three months in 52.1% of cases and at six months in 21.7% of the cases. Age > 41 (p = 0.001, OR: 1.588; 95% CI: 0.935–2.695) and having the O-type blood group (p = 0.033, OR: 0.704; 95% CI: 0.448–1.105) were found to be significant risk factors for the persistence of joint pain. Conclusion Our study indicates polyarthralgia, fever, and skin rash as a triad of symptoms during the acute phase. Persistent arthralgia was a frequent long-term complication of chikungunya fever in which increasing age was identified to be a significant risk factor.

show abstract

A case of chikungunya virus disease presenting with remarkable acute arthritis of a previously damaged finger joint

Cited by 3 publications

References 11 publications

The Identification of Risk Factors for Chronic Chikungunya Arthralgia in Grenada, West Indies: A Cross-Sectional Cohort Study

The Identification of Risk Factors for Chronic Chikungunya Arthralgia in Grenada, West Indies: A Cross-Sectional Cohort Study

Bone erosions and joint damage caused by chikungunya virus: a systematic review

Acute clinical features and persistence of joint pain in probable cases of Chikungunya Fever in Eritrea

Contact Info

Product

Resources

About