Aspirin plus verapamil relieves angina and perfusion abnormalities in patients with coronary microvascular dysfunction and Chagas disease: a pilot non-randomized study

Pavão, Rafael Brolio; Moreira, Henrique T.; Pintya, Antonio Osvaldo; Haddad, Jorge; Badran, André Vannuchi; Lima-Filho, Moysés de Oliveira; Lago, Igor Matos; Chierice, João Reynaldo Abbud; Schmidt, André; Marin‐Neto, José Antônio

doi:10.1590/0037-8682-0181-2021

Cited by 6 publications

(1 citation statement)

References 53 publications

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“…The pathophysiology of microvascular CAD in patients with CCD is not fully understood at this time; however, abnormalities in the microcirculation caused by vasospasm and platelet aggregation associated with inflammation and autonomic dysfunction have been postulated ( 17 , 18 ). In this regard, a 3-month treatment with verapamil (80 mg/bid) and acetylsalicylic acid (100 mg/once a day) reduced the burden of ischemic episodes in patients with CCHD with microvascular CAD ( 19 ).…”

Section: Cardiovascular Diseases Managementmentioning

confidence: 99%

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Bestetti

Bocchi²,

Bestetti³

et al. 2022

Front. Med.

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Cardiovascular diseases (CVD) are the most important cause of morbidity and mortality in the general population. Because the high prevalence of COVID-19 and chronic Chagas disease (CCD) where the latter is endemic, all such diseases will likely be observed in the same patient. While COVID-19 can provoke generalized endotheliitis, which can lead to a cytokine storm and a hyper-coagulable state culminating into in-site and at a distance thrombosis. Therefore, small-vessel coronary artery disease (CAD), cerebrovascular disease, thromboembolism, and arrhythmias are prominent findings in COVID-19. In CCD, small-vessel CAD, cardioembolic stroke, pulmonary embolism, heart failure and arrhythmias are frequently observed as a result of a similar but less intense mechanism. Consequently, the association of CCD and COVID-19 will likely increase the incidence of CVD. Thus, doctors on the frontline should be on the alert for this diagnostic possibility so that the proper treatment can be given without any delay.

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Section: Cardiovascular Diseases Managementmentioning

confidence: 99%