The recent arbovirus disease epidemic in Brazil

Figueiredo, Luíz Tadeu Moraes

doi:10.1590/0037-8682-0179-2015

Cited by 31 publications

(28 citation statements)

References 3 publications

(1 reference statement)

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“…These viral loads typical of acute infection by CHKV were easily detected by the SYBR Green I real-time RT-PCR. However, we did not detect any alphavirus in the serum of patients with acute febrile illness from Southeast (Sao Paulo State) and Central-West (Mato Grosso State) Brazil, probably because the native viruses do not frequently produce disease and especially because our analyzed cases occurred before the introduction of CHIKV in Brazil [5,20].…”

Section: Discussionmentioning

confidence: 65%

“…Alphaviruses, specially VEEV, MAYV and more recently CHIKV, have caused several outbreaks in South America of high impact in human and animal public health [5,7,15,18,20,23,32]. Other zoonotic alphaviruses are also circulating in the area causing sporadic human diseases.…”

Section: Discussionmentioning

confidence: 99%

“…In the Caribbean, CHIKV was responsible for 700,000 to 1.3 million infections in 45 countries or territories [17,21,29]. In 2014, Brazil suffered two introductions of CHIKV, one by the Asian strain in the North and another by the East, Central and South African strain in the Northeast [5]. Additionally, numerous alphaviruses, such as the Eastern equine encephalitis (EEEV), Western Equine Encephalitis (WEEV) and Venezuelan Equine encephalitis have produced many epizootics in ungulates and epidemics in human populations of the Americas [13,36].…”

Section: Introductionmentioning

confidence: 99%

“…Consequentially, the wide variety of reservoirs coupled with the spreading of both vectors and viruses through international travel has led to the global distribution of these viruses. Moreover, the lack of effective antiviral treatments or human vaccines have enabled alphaviruses to become a threat that can result in explosive epidemics, as recently described for CHIKV in the Americas [5,20,36].…”

Section: Introductionmentioning

confidence: 99%

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A real-time RT-PCR for rapid detection and quantification of mosquito-borne alphaviruses

et al. 2016

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Mosquito-borne alphaviruses are widely distributed throughout the world, causing important human illnesses. Therefore, the development of methods to enable early diagnosis of infections by alphavirus is essential. We show here the development and evaluation of a quantitative real-time RT-PCR using genus-specific primers to the nsP1 viral gene of all mosquito-borne alphaviruses. The specificity and sensitivity of the assay were tested using seven alphaviruses and RNA transcribed from Venezuelan equine encephalitis virus. The detection limits of real-time RT-PCR ranged from 10 to 76 copies per ml. The melting temperature (T M ) values for amplification of the alphavirus genomes were 83.05°C and 85.28°C. Interestingly, the assay suggested the possibility the arthritogenic alphaviruses with T M peaks of 84.83 to 85.28°C and encephalitic alphaviruses of 83.34°C to 84.68°C could be discriminated both diseases. Real-time RT-PCR may prove very useful for the screening and preliminary diagnosis in outbreaks and surveillance studies as well as for measuring the viral load in pathogenesis studies.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A real-time RT-PCR for rapid detection and quantification of mosquito-borne alphaviruses

et al. 2016

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“…First, cases of flaccid paralysis from Guillain-Barré syndrome were associated with the viral infection. More importantly, in September 2015, cases of severe ZIKV-related congenital disease that produced extensive destruction of the central nervous system were associated with maternal infection (7) . As of August 2016, 196,976 probable cases of ZIKV in the entire country were reported.…”

Section: How Are So Many Foreign Arboviruses Introduced In Brazil?mentioning

confidence: 99%

How are so many foreign arboviruses introduced in Brazil?

Figueiredo

2016

Rev. Soc. Bras. Med. Trop.

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Cross reactivity of commercial anti‐dengue immunoassays in patients with acute Zika virus infection

Félix

Souza

Figueiredo

et al. 2017

Journal of Medical Virology

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Several countries have local transmission of multiple arboviruses, in particular, dengue and Zika viruses, which have recently spread through many American countries. Cross reactivity among Flaviviruses is high and present a challenge for accurate identification of the infecting agent. Thus, we evaluated the level of cross reactivity of anti-dengue IgM/G Enzyme-Linked Immunosorbent Assays (ELISA) from three manufacturers against 122 serum samples obtained at two time-points from 61 patients with non-dengue confirmed Zika virus infection. All anti-dengue ELISAs cross reacted with serum from patients with acute Zika infection at some level and a worrisome number of seroconversion for dengue IgG and IgM was observed. These findings may impact the interpretation of currently standard criteria for dengue diagnosis in endemic regions.

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The recent arbovirus disease epidemic in Brazil

Cited by 31 publications

References 3 publications

A real-time RT-PCR for rapid detection and quantification of mosquito-borne alphaviruses

A real-time RT-PCR for rapid detection and quantification of mosquito-borne alphaviruses

How are so many foreign arboviruses introduced in Brazil?

Cross reactivity of commercial anti‐dengue immunoassays in patients with acute Zika virus infection

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