Comparative study of lymphocytes from individuals that were vaccinated and unvaccinated against the pandemic 2009-2011 H1N1 influenza virus in Southern Brazil

Freitas, Deise Nascimento de; Isaía, Henrique Ataíde; Henzel, Andréia; Simão, Éder Maiquel; Gassen, Rodrigo Benedetti; Rodrigues, Luiz Carlos

doi:10.1590/0037-8682-0163-2015

Cited by 1 publication

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References 34 publications

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“…In contrast, the decrease in αβ T cells and B cells in pigs covers a period of four to seven days with recovery until day 14 and is comparable with decreasing frequencies in patients infected with H1N1pdm09 although the period of mild lymphopenia varies between studies [43, 46, 52]. However, after the second infection, recovery was faster compared to the first infection and thus comparable to vaccinated humans [53, 54]. Further, we detected an increased proliferative activity in CD4 + /CD8 + T cells (constituting of cytotoxic and memory cells) and cytotoxic (CD8 + ) subtypes of αβ T cells, which was pronounced after first infection with a lesser increase after second infection resembling a memory response.…”

Section: Discussionmentioning

confidence: 97%

Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections

et al. 2019

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Pigs are anatomically, genetically and physiologically comparable to humans and represent a natural host for influenza A virus (IAV) infections. Thus, pigs may represent a relevant biomedical model for human IAV infections. We set out to investigate the systemic as well as the local immune response in pigs upon two subsequent intranasal infections with IAV H1N1pdm09. We detected decreasing numbers of peripheral blood lymphocytes after the first infection. The simultaneous increase in the frequencies of proliferating cells correlated with an increase in infiltrating leukocytes in the lung. Enhanced perforin expression in αβ and γδ T cells in the respiratory tract indicated a cytotoxic T cell response restricted to the route of virus entry such as the nose, the lung and the bronchoalveolar lavage. Simultaneously, increasing frequencies of CD8αα expressing αβ T cells were observed rapidly after the first infection, which may have inhibited uncontrolled inflammation in the respiratory tract. Taking together, the results of this study demonstrate that experimental IAV infection in pigs mimics major characteristics of human seasonal IAV infections.

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