The relationship between atopy and neurological manifestations in HTLV-1 infection

Verde, Raquel Crisóstomo Lima; Neto, José Abraão Carneiro; Santos, Sara; Carvalho, Edgar M.; Lessa, Marcus Miranda

doi:10.1590/0037-8682-0162-2017

Cited by 1 publication

(1 citation statement)

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“…HAM/TSP, the most devastating neurologic consequence of HTLV-1, occurs in about 0.25-5% of infected individuals (usually adults in their fourth to fifth decade of life) 3 . The chronic progressive demyelination and degeneration of the first motor neurons determine the main clinical findings of spastic paraparesis, a positive Babinski reflex, and weakness in the lower extremities, among other signs of positive pyramidal release 4,5 . Consequently, many HAM/TSP patients present gait disturbances of varying frequency and severity.…”

Section: Introductionmentioning

confidence: 99%

Impact of fractures and orthopedic surgeries in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis

Julca-Copello

Schwalb

Cachay

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: In patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) gait disturbance is a predominant feature that leads to falls and fractures, which can further aggravate disability. We sought to evaluate the impact of fractures and orthopedic surgeries in patients with HAM/TSP. Methods: We retrieved the medical records of HAM/TSP patients enrolled in our study center's HTLV-1 clinical cohort between 1989-2018. The selection criteria included: (1) diagnosis of HTLV-1 infection using two enzyme-linked immunosorbent assays and/or a confirmatory test, (2) clinical diagnosis of HAM/TSP by neurological assessment, and (3) fractures associated with HAM/TSP. Results: We identified 24 cases of fractures, 70% of which were females. The median age at the time of fracture was 60 years (IQR=24). Six cases reported fractures in patients under 45 years old. Ten patients (42%) had hip/coccyx fractures, seven (29%) were in the lower extremities, and four (17%) in the upper extremities. Half of these patients reported the use of wheelchairs. Five patients who had previously used canes required the use of wheelchairs after the reported fracture. Eight patients underwent corrective orthopedic surgery as a result of the fracture. Conclusions: For HAM/TSP patients, fractures are a complication that can exacerbate their severe impairment.

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Section: Introductionmentioning

confidence: 99%

Impact of fractures and orthopedic surgeries in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis

Julca-Copello

Schwalb

Cachay

et al. 2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

The relationship between atopy and neurological manifestations in HTLV-1 infection

Abstract: Abnormal Th1 and Th2 responses coexist in HTLV-1-infected individuals and allergic diseases may worsen the clinical course of HTLV-1 infections.

Cited by 1 publication

References 14 publications

Impact of fractures and orthopedic surgeries in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis

Impact of fractures and orthopedic surgeries in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis

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