Outbreak of laboratory-acquired Brucella abortus in Brazil: a case report

Rodrigues, Ana Luisa Calixto; Silva, Stéphanie Kneipp Lopes da; Pinto, Bárbara Luíza Alves; Silva, Jane Braga da; Tupinambás, Unaí

doi:10.1590/0037-8682-0160-2013

Cited by 15 publications

(11 citation statements)

References 9 publications

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“…In Brazil, brucellosis in cows [ 6 ], dogs [ 7 ], buffalos [ 8 ], sheep [ 9 ], goats [ 10 ], deer [ 11 ], horses [ 12 ], dolphin [ 13 ], and other animals has been reported. Human cases [ 14 ] and outbreak of laboratory-acquired Brucella abortus [ 15 ] have been described sporadically. However, serosurvey studies suggest that the infection is more prevalent than reported [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018

et al. 2018

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BackgroundHuman brucellosis (HB) is a bacterial zoonosis that is more frequent in low income and middle-income countries; it is sometimes associated with outbreaks. The aim of this study was to describe the largest outbreak of HB in Brazil.MethodsA retrospective cohort study of patients suspected of having contracted HB in the state of Paraná, Southern Brazil from January 2009 to January 2017. Following an outbreak of 51 cases of HB in a slaughterhouse at Paiçandu in 2014, HB was defined as an obligatory reportable disease in the State. Diagnostic tests for HB included serum agglutination, ELISA (IgG or IgM) and polymerase chain reaction (PCR). Clinical, laboratorial and epidemiological data were analyzed. A P value of 0.05 was considered statistically significant.ResultsOut of a total of 3,941 patients, 754 presented with a positive test result for HB. After 2014, there was a significant increase in the number of cases, exceeding 100 cases per trimester. In the beginning of 2015, the workgroup of HB started several actions for prevention and treatment, and the number of cases progressively diminished to fewer than 20 cases per trimester. Of 191 reported cases, an occupational risk was found in 84.7%; most cases occurred in farmers (60.0%), veterinarians (17.6%) and slaughterhouse workers (14.7%). Manipulation of animals and unpasteurized milk consumption were associated with positive Brucella IgM ELISA with an odds ratio (OR) of 1.42 (1.09–1.84) and 1.48 (1.01–2.15), respectively.ConclusionsHB outbreaks can occur in low to middle-income countries and are associated with slaughterhouse work, handling of unpasteurized milk and animal manipulation. Intensive programs for control of HB are important to reduce the number of cases.

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Section: Introductionmentioning

confidence: 99%

Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018

et al. 2018

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“…It is a multi-systemic illness, with a broad clinical spectrum, ranging from asymptomatic chronic infection to severe or deadly disease [8][9][10]. Brucella infection is rare during pregnancy but may be associated with abortion, premature delivery, chorioamnionitis and intrauterine fetal death (IUFD).…”

Section: Introductionmentioning

confidence: 99%

Development of Severe Fever due to Brucellosis after Cesarean: Case Report from Iran

Sabzevari¹,

Badirzadeh²,

Kalateh³

et al. 2018

JCR

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Background: Brucellosis, a zoonotic disease caused by Brucella spp., is an endemic infectious disease in many developing countries that causes significant economic loss. Case Report: Here, we would like to report an unusual case of human brucellosis; a 32-year-old woman who was undergone cesarean and immediately became febrile after operation. An unusual cause of post-operative fever was diagnosed brucellosis by using serologic tests. She had been treated with a combination of antimicrobials with significant clinical improvement. Conclusion: Obstetricians in endemic areas such as Iran should consider brucellosis as an unknown cause of fever.

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“…The exposure time is less due to less manipulation of the agent, as biochemical tests are no longer necessary. This is important because, of all reported cases of human brucellosis, 2% infection are associated with laboratory work (COLLINS, 1983), with an attack rate of 30 to 100% (ERGÖNÜL et al, 2004), including a severe case recorded in Brazil (RODRIGUES et al, 2013).…”

Section: Introductionmentioning

confidence: 99%