Anti-Candida and anti-quorum sensing activity of airborne microorganisms detected by a rapid method

Abstract

Introduction: Introducing new antibiotics to the clinic is critical. Methods: We adapted a plate method described by Kawaguchi and coworkers in 2013 1 for detecting inhibitory airborne microorganisms. Results: We obtained 51 microbial colonies antagonist to Chromobacterium violaceum, purified and retested them, and of these, 39 (76.5%) were confirmed. They comprised 24 bacteria, 13 fungi, and 2 yeasts. Among the fungi, eight (61.5%) produced active extracts. Among the bacterial, yeast, and fungal strains, 17 (44.7%) and 12 (31.6%) were active against Candida albicans and Candida parapsilosis, respectively. Conclusions: The proposed screening method is a rapid strategy for discovering potential antibiotic producers.

Mining the nanotube-forming Bacillus amyloliquefaciens MR14M3 genome for determining anti-Candida auris and anti-Candida albicans potential by pathogenicity and comparative genomics analysis

“…Previous studies used molecular methods to identify and confirm C. auris CA1 to prevent incorrect diagnosis, and various drug-resistant mutations were identified in the lanosterol 14-α demethylase ( ERG11 ) and TAC1B (zinc-cluster transcription factor-encoding) genes [8] , [36] . Several sources of bacteria are promising sources for finding anti- Candida potential [30] , [31] , [54] , [55] , [56] , [57] , [58] . To manage the C. auris -related spread of infection, new promising medicines are still needed [28] .…”

Evaluation of culture media and conditions of Amazonian filamentous fungi in an antimicrobial screening program

“…The study was carried out with twelve filamentous fungi, six isolateds from different types of Amazonian soil (unpublished data) and six air isolates (anemophiles) in a previous study (Cruz, Souza de & Abegg, 2019). These fungi were pre-selected for preliminary antimicrobial activity results (data not shown).…”