Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children

Abstract

Introduction:The therapeutic scheme of triclabendazole (TCBZ), the recommended anthelmintic against Fasciola hepatica, involves 10mg/kg of body weight administered in a single dose; however, clinical trials in children are scarce. We evaluated the effi cacy and tolerability of 2 schemes of TCBZ. Methods: Eighty-four Peruvian children with F. hepatica eggs in their stools were allocated into 2 groups: 44 received 2 dosages of 7.5mg/kg each with a 12-h interval (Group I), and 40 received a single 10-mg/kg dose (Group II). Evaluation of effi cacy was based on the presence of eggs in stools, and tolerability was based on the presence of symptoms and signs post-treatment. Results: A parasitological cure was obtained in 100% of individuals from Group I and 95% of individuals from Group II. The most common adverse event was biliary colic. Conclusions: The tested scheme was effi cacious and tolerable, and it might be an optimal scheme in the region. To the best of our knowledge, this represents the largest series of children treated with TCBZ in a non-hospital setting.

Human liver flukes

“…Cure rates of 92·2-100% are described in adults with a two-dose regimen (117,118) , with 79·2% cure rates described with the single-dose regimen (119) . Cure rates of 95% using the 10mg/kg dose have recently been described in children, with 100% cure rates using two doses of 7.5mg/kg (120) . Reports of resistance to triclabendazole in livestock are increasingly common, and more recently likely resistance in human fascioliasis has been detected in the Netherlands and Peru (121,122) .…”

Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review

“…The doses were spaced 24 hours apart. 8 At follow-up 6 weeks later, she reported complete symptom resolution. Her leukocytes had decreased to 7,500/μL from 16 to 20,000/μL and her eosinophils fell to 1,700/μL (23%) from 9,800/μL (45%).…”

Fracaso de dosis única de triclabendazole para el tratamiento de fasciolosis humana

“…El tratamiento correcto y efectivo de fasciolosis es sumamente importante y necesario para evitar las complicaciones clínicas por esta infección tales como colangitis, fibrosis del hígado, hematoma subscapular del hígado, anemia y cirugías innecesarias [14][15][16] . En áreas donde la resistencia al TCBZ aun no ha sido reportada, las tasas de curación alcanzan casi el 100% [17] . No obstante, se han reportado casos humanos de resistencia al TCBZ en algunas zonas de Sudamérica [5,18] .…”