A Saint Louis encephalitis and Rocio virus serosurvey in Brazilian horses

CCR2 Plays a Protective Role in Rocio Virus–Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain

“…The increased expansion of arthropod vectors raises the possibility of ROCV spreading to new geographic areas. Several serological surveys indicated the possibility of ROCV circulation among asymptomatic humans, horses, and wild animals in different regions of Brazil [7][8][9][10][11]. The pathogenesis of ROCV still remains poorly understood, and a suitable animal model mimicking human disease for ROCV has not been well described and characterized.…”

“…Interestingly, no further human outbreaks of ROCV have been described since the 1975-1976 outbreak. However, numerous serological surveys indicated the possibility of ROCV circulation among asymptomatic humans and native animals in different regions of Brazil [7][8][9][10][11]. The absence of further ROCV outbreaks in humans points to the possibility of crossprotective immunity elicited by prior infections with other circulating flaviviruses within the Brazilian population.…”

Zajímavosti Ze Světa Arbovirových Nákaz

“…Rocio virus může u pacienta vyvolat encefalitidu, která je ve zhruba 10% případů fatální. V přibližně 20% případů nástávají u pacientů trvalé neurologické změny [57]. Virus řadíme mezi BSL3 biologická agens, tzn.…”

A reemergência do vírus Rocio no Brasil

“…2 Finalmente, há evidência recente de infecção ROCV generalizada entre cavalos no Brasil. 4 Os cavalos são grandes animais domésticos que vivem fora da proteção de edifícios e, portanto, são vítimas de picadas de mosquito comum. Para os autores, esses animais são uma fonte adequada para estudos soroepidemiológicos sobre vírus transmitidos por mosquitos,…”