“… 23 MRI can demonstrate enlargement of the spinal cord, with an intramedullary expansive lesion, that shows hypointense signal on T2-weighted imaging, gadolinium-enhancement and peripheral edema, similar findings of a granuloma ( Figure 9 ). 58–61 The differential diagnosis for this kind of lesion is intramedullary neoplasms, such as ependymoma and astrocytoma, as well as pseudotumoral infectious and inflammatory lesions, such as tuberculosis and sarcoidosis. Figure 9 A 37-year-old man presented with paraplegia in the lower limbs and urinary incontinence.…”
Section: Imaging Featuresmentioning
confidence: 99%
“…23 MRI can demonstrate enlargement of the spinal cord, with an intramedullary expansive lesion, that shows hypointense signal on T2-weighted imaging, gadolinium-enhancement and peripheral edema, similar findings of a granuloma (Figure 9). [58][59][60][61] Figure 7 Note how MRI can help to differentiate a typical granuloma, from an abscess, and a high grade neoplasm. Granuloma typically has a hypointense signal on T2weighted imaging, peripheral contrast enhancement, with no restricted diffusion and reduced rCBV.…”
Paracoccidioidomycosis (PCM) is a infection caused by the thermodimorphic fungus
Paracoccidioides
spp. (P.
lutzii
and, mainly,
P. brasiliensis
). This infection predominantly affects rural male workers aged between 30 and 50 years old who deal with soil on daily activities. Clinically, the disease is classified as acute/subacute phase, which evolves rapidly, secondary to dissemination of the fungus through to the phagocytic-mononuclear system, leading to fever, weight loss, and anorexia, associated with hepatosplenomegaly and lymphadenopathy, which can be complicated with suppuration and fistulization; and chronic phase, which corresponds to 74% to 95% of symptomatic cases, with a common pulmonary involvement. Central nervous system involvement is almost always a characteristic of the chronic form. Inhalation is the most common route of primary infection, usually affecting the lungs, forming the primary complex. From the primary complex, hematogenic dissemination can occur to any organ, including the brain and spinal cord. Although PCM of the central nervous system diagnosis is usually based on histopathological analysis and the imaging features are not specific for PCM, computed tomography and magnetic resonance imaging can demonstrate evidences of granuloma, abscess, meningitis, or a combination of these lesions, contributing to a preoperative diagnosis, especially when considered in conjunction with epidemiology. In this article, we review the pathophysiology, clinical manifestations and imaging aspects of neuro-PCM.
“… 23 MRI can demonstrate enlargement of the spinal cord, with an intramedullary expansive lesion, that shows hypointense signal on T2-weighted imaging, gadolinium-enhancement and peripheral edema, similar findings of a granuloma ( Figure 9 ). 58–61 The differential diagnosis for this kind of lesion is intramedullary neoplasms, such as ependymoma and astrocytoma, as well as pseudotumoral infectious and inflammatory lesions, such as tuberculosis and sarcoidosis. Figure 9 A 37-year-old man presented with paraplegia in the lower limbs and urinary incontinence.…”
Section: Imaging Featuresmentioning
confidence: 99%
“…23 MRI can demonstrate enlargement of the spinal cord, with an intramedullary expansive lesion, that shows hypointense signal on T2-weighted imaging, gadolinium-enhancement and peripheral edema, similar findings of a granuloma (Figure 9). [58][59][60][61] Figure 7 Note how MRI can help to differentiate a typical granuloma, from an abscess, and a high grade neoplasm. Granuloma typically has a hypointense signal on T2weighted imaging, peripheral contrast enhancement, with no restricted diffusion and reduced rCBV.…”
Paracoccidioidomycosis (PCM) is a infection caused by the thermodimorphic fungus
Paracoccidioides
spp. (P.
lutzii
and, mainly,
P. brasiliensis
). This infection predominantly affects rural male workers aged between 30 and 50 years old who deal with soil on daily activities. Clinically, the disease is classified as acute/subacute phase, which evolves rapidly, secondary to dissemination of the fungus through to the phagocytic-mononuclear system, leading to fever, weight loss, and anorexia, associated with hepatosplenomegaly and lymphadenopathy, which can be complicated with suppuration and fistulization; and chronic phase, which corresponds to 74% to 95% of symptomatic cases, with a common pulmonary involvement. Central nervous system involvement is almost always a characteristic of the chronic form. Inhalation is the most common route of primary infection, usually affecting the lungs, forming the primary complex. From the primary complex, hematogenic dissemination can occur to any organ, including the brain and spinal cord. Although PCM of the central nervous system diagnosis is usually based on histopathological analysis and the imaging features are not specific for PCM, computed tomography and magnetic resonance imaging can demonstrate evidences of granuloma, abscess, meningitis, or a combination of these lesions, contributing to a preoperative diagnosis, especially when considered in conjunction with epidemiology. In this article, we review the pathophysiology, clinical manifestations and imaging aspects of neuro-PCM.
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