First report of yellow fever virus in non-human primates in the State of Parana, Brazil

Tranquilin, M.V.; Lehmkuhl, Ricardo Coelho; Maron, Angela; Silva, Lineu Roberto da; Ziliotto, Liane; Seki, Meire Christina; Salomon, Gabriela Ronchi; Carrasco, Adriano de Oliveira Torres

doi:10.1590/0037-8682-0106-2013

Cited by 12 publications

(7 citation statements)

References 6 publications

(23 reference statements)

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“…The results obtained in this study assessing the main liver lesions and in ammatory in ltrate agree with other authors who described in ammatory in ltrates of mild to moderate intensity and associated these with midzone injury and intense presence of Councilman bodies in hepatocytes (cells under going apoptosis) followed by macro-and microvesicular steatosis and lytic and coagulative necrosis (5,11,12,13,24,25,26). Frequently associated with these changes are swelling, hepatocyte regenerative changes, hyperplasia and hypertrophy of Kupffer cells, sinusoidal congestion, and haemorrhage of the parenchyma.…”

Section: Discussionsupporting

confidence: 92%

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Role of Th17 Cytokines in Liver’s Immune Response during Fatal Yellow Fever:Triggering Cell Damage Mechanism

Carvalho

Sousa

Lopes

et al. 2021

Preprint

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Yellow fever (YF) is an infectious disease whoseevolution and outcome arerelated to the host immune response pattern. We investigated the Th17 cytokine profile in the liver of humans with fatal YF. Liver tissue samples were collected from 26 patients, including 21 YF-positive and five flavivirus-negative patients with preserved hepatic parenchyma architecture who died of other causes. Samples underwent histopathological and immunohistochemical analysis to detect the Th17 profile (ROR-γ, STAT3, IL-6, TGF-β, IL-17,and IL-23). Substantial differences were found in the expression of markers between fatal YF cases and control samples with a predominance of Th17 cytokine markers in the midzonal region of the YF cases, the most affected area in the liver acinus. Histopathological changes in the hepatic parenchyma revealed cellular damage characterised mainly by the presence of inflammatory infiltrate, Councilman bodies (apoptotic cells), micro/macrovesicular steatosis, and lytic and coagulative necrosis.Th17 cytokines play a pivotal role during YF and contribute significantly to triggering the mechanisms of cell damage in the fatal outcome of severe cases.

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Section: Discussionsupporting

confidence: 92%

“…Historically, YF has been considered an infectious haemorrhagic disease with a major impact on public health. In this study, we have described the relationship between histopathological changes and cellular and cytokine immune response patterns in the liver of patients who died of severe YF due to hepatic-renal failure [13,23,24,25].…”

Section: Discussionmentioning

confidence: 99%

Role of Th17 Cytokines in Liver’s Immune Response during Fatal Yellow Fever:Triggering Cell Damage Mechanism

Carvalho

Sousa

Lopes

et al. 2021

Preprint

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“…Other studies from previous epizootic events failed to detect YFV in Sapajus spp. monkeys 9,28 . On the other hand, NHPs belonging to the Alouatta genus were highly infected with YFV as previously reported in this country 29,30 .…”

Section: Discussionmentioning

confidence: 99%

Epizootics due to Yellow Fever Virus in São Paulo State, Brazil: viral dissemination to new areas (2016–2017)

Cunha

Costa

Fernandes

et al. 2019

Sci Rep

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Beginning in late 2016 Brazil faced the worst outbreak of Yellow Fever in recent decades, mainly located in southeastern rural regions of the country. In the present study we characterize the Yellow Fever Virus (YFV) associated with this outbreak in São Paulo State, Brazil. Blood or tissues collected from 430 dead monkeys and 1030 pools containing a total of 5,518 mosquitoes were tested for YFV by quantitative RT-PCR, immunohistochemistry (IHC) and indirect immunofluorescence. A total of 67 monkeys were YFV-positive and 3 pools yielded YFV following culture in a C6/36 cell line. Analysis of five nearly full length genomes of YFV from collected samples was consistent with evidence that the virus associated with the São Paulo outbreak originated in Minas Gerais. The phylogenetic analysis also showed that strains involved in the 2016–2017 outbreak in distinct Brazilian states (i.e., Minas Gerais, Rio de Janeiro, Espirito Santo) intermingled in maximum-likelihood and Bayesian trees. Conversely, the strains detected in São Paulo formed a monophyletic cluster, suggesting that they were local-adapted. The finding of YFV by RT-PCR in five Callithrix monkeys who were all YFV-negative by histopathology or immunohistochemistry suggests that this YFV lineage circulating in Sao Paulo is associated with different outcomes in Callithrix when compared to other monkeys.

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“…The high seroprevalence of DENV‐2 and DENV‐3 is remarkable and aspects concerning their presence, for example, role as reservoir and possible sylvatic cycle should be further investigated. Concerning the presence of anti‐YFV antibodies, although YF is highly lethal for NHP, however, it is worth noting that among the new world primates, the capuchin monkeys are one of the most resistant to YFV infection (Moreno et al., ; Tranquilin et al., ). In addition, the presence of these viruses in capuchin monkeys would have public health, as well as animal health and conservation importance.…”

Section: Frequency Of Positive Samples On the Prnt90 Per Flavivirusesmentioning

confidence: 99%

Seroprevalence of selected flaviviruses in free-living and captive capuchin monkeys in the state of Pernambuco, Brazil

Oliveira-Filho

Oliveira

Ferreira

et al. 2018

Transbound Emerg Dis

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Mosquito-borne diseases such as dengue, yellow fever and, more recently, Chikungunya virus (CHIKV) and Zika virus (ZIKV) have a great impact in the public health. In addition, the presence of such viruses might have an impact on wild animal conservation as well as their possible role as animal reservoir. Here, we performed a serological survey searching for antibodies against a panel of flaviviruses [ZIKV, Dengue virus (DENV), Yellow Fever virus (YFV), West Nile virus (WNV), Saint Louis Encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV)] using plaque reduction neutralization test (PRNT ) in both free-ranging and captive capuchin monkeys (Sapajus flavius and Sapajus libidinosus). Captive and free-living monkeys were sampled between June 2015 and January 2016 in the state of Pernambuco, including in the border with State of Paraíba, the epicentre of the ZIKV epidemics in Brazil. We have found neutralizing antibodies for ZIKV, DENV-1, DENV-2, DENV-3, DENV-4, YFV, ILHV and SLEV in both S. flavius and S. libidinosus samples. No positives samples were found for ROCV and WNV. Our results suggest that these flaviviruses might be circulating in capuchin monkey in the studied region. The possible presence of these viruses represents a risk for public health, as well as for animal conservation, especially for S. flavius which is a critically endangered species, facing high risk of extinction.

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First report of yellow fever virus in non-human primates in the State of Parana, Brazil

Cited by 12 publications

References 6 publications

Role of Th17 Cytokines in Liver’s Immune Response during Fatal Yellow Fever:Triggering Cell Damage Mechanism

Role of Th17 Cytokines in Liver’s Immune Response during Fatal Yellow Fever:Triggering Cell Damage Mechanism

Epizootics due to Yellow Fever Virus in São Paulo State, Brazil: viral dissemination to new areas (2016–2017)

Seroprevalence of selected flaviviruses in free-living and captive capuchin monkeys in the state of Pernambuco, Brazil

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