Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro

Abstract

Introduction:In this study, we evaluated hepatitis C virus (HCV) and human immunodefi ciency virus (HIV) -platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. Methods: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. Results: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. Conclusions: HIV-platelet ligation could be more effi cient than HCV-platelet interaction. Further, the HPA-1b allele seems to infl uence the interaction of platelets with HCV.

Association of human platelet antigens polymorphisms with susceptibility to hepatitis C virus infection in Chinese population

“…Moreover, Grotto et al. () evaluated HCV–platelet and HIV–platelet interactions in vitro as well as HPA‐1, HPA‐3 and HPA‐5 polymorphisms. The authors concluded that platelet–HCV interaction seems to be influenced by the presence of the HPA‐1b allele.…”

“…In a recent report, the HPA-1 seems to influence the interaction of platelets with HCV in vitro (Grotto et al, 2016). Verdichio-Moraes, Toralles-Pereira, Grotto, Silva, and Pardini (2009) indicated a possible association between HCV infection and HPA-5 in Brazil population.…”