Larvicidal activity of plants from Myrtaceae against Aedes aegypti L. and Simulium pertinax Kollar (Diptera)

Carneiro, Vanessa Cristine de Souza; Lucena, Luana Braz de; Figueiró, Ronaldo; Victório, Cristiane Pimentel

doi:10.1590/0037-8682-0092-2020

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…Another important point is that this study is in line with previous studies (Neves et al, 2017;Carneiro et al, 2021) which has reported on the larvicidal activity of plants of the family Myrtaceae.…”

Section: Discussionsupporting

confidence: 91%

Chemical composition and larvicidal activity of the essential oil of Pimenta dioica leaves

Gomes¹,

Marinho²,

Everton³

et al. 2022

BLACPMA

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In this study, we investigated the main constituent, the predominant class and biological activity of the essential oil extracted from the leaves of Pimenta dioica and the pattern of the major constituent against larvae in the third stage of Aedes aegypti. For this reason, we extracted the oil by hydrodistillation, identified its components by gas chromatography coupled with mass spectrometry (GC/MS) and calculated the lethal concentration (LC50) of the larvicidal activity using the Reed-Muench method. The results show that the oil consists mainly of eugenol, in which the phenylpropanoid class predominated and the lethal concentration, LC50, was 38.86 μg mL-1at a confidence level of 2.25 μg mL-1, while the eugenol standard presented LC5079.75 μg mL-1at a confidence level of 2.10 μg mL-1. Given the facts, we conclude that the oil is more active than the standard and that it has the potential to replace chemical larvicides.

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Section: Discussionsupporting

confidence: 91%

Chemical composition and larvicidal activity of the essential oil of Pimenta dioica leaves

Gomes¹,

Marinho²,

Everton³

et al. 2022

BLACPMA

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“…tested the methanolic extract of Lycopodium clavatum against Ae. aegypti larvae and obtained a LC50 value of 388.66 pmm/mL, which is twice as high as the LC50 obtained, which was 78.81µg/mL Carneiro et al, (2021). demonstrated the larvicidal activity of the methanolic extract of Eugenia astringens leaves against Ae.…”

mentioning

confidence: 58%

Larvicidal activity of cloves as an alternative to chemical control in mosquito vectors in the Amazonia under laboratory conditions

Vale,

Rodrigues,

Roque

et al. 2023

RSD

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Mosquito-borne diseases continue to be the main causes of death in many tropical countries. Among the infectious diseases transmitted by mosquitoes, malaria and dengue fever remain a major public health concern. Chemical control is the most widely used method for controlling and preventing mosquito-borne diseases. However, there are reports in the literature about resistance in populations due to the continuous use of chemical insecticides. In this sense, products of plant origin, such as plant extracts, essential oils and plant derivatives, have emerged as a promising alternative. In this study, bioassays were carried out to evaluate the activity of the aqueous and methanolic extracts of cloves (Syzigium aromaticum) in laboratory conditions against Anopheles darlingi and Aedes aegypti larvae. The bioassays carried out with An. darlingi showed CL50 values of 6.41 µg/mL for the methanolic extract and CL50 values of 5.65 µg/mL for the aqueous extract. Considering the bioassays with Ae. aegypti larvae (aqueous extract), the CL50 value was 78.81 µg/mL and the methanolic extract showed a CL50 value of 131.10 µg/mL. The larvicidal activity of the methanolic extract (CL50 131.10 µg/mL) against Ae. aegypti larvae was much lower than that obtained with An. darlingi. Comparing the two mosquito species, An. darlingi was more susceptible to the aqueous and methanolic extracts. However, when comparing the activity of the extracts against An. darlingi, it was found that the aqueous and methanolic extracts were active. With regard to Ae. aegypti larvae, they were more susceptible to the aqueous extract.

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“…These data indicate the need to assess the cytotoxicity of this species within the specific parts of this plant and in the fractions of different polarities of its extracts. However, no study in the literature has pointed out these variations in N. obscura, and there is only one study that indicates that high concentrations of the methanol fraction of leaf extract induced maximum mortality of 46.66% in A. aegypti larvae after 48 hours (LC50 = 25 ppm) (Carneiro et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of plant extract effects on peritoneal, medullary and J774 cells. G8 macrophages

et al. 2023

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The use of medicinal plants as raw material for extracts production and pure substances isolation and subsequence development of new drugs represents a constantly growing area. However, some stages are indispensable before pharmacologically evaluating natural products such as medicines. Toxicity tests in mammalian cells are essential to initiate new drugs development or verify the substance’s biocompatibility. Thus, we verified the toxicity of crude extracts and fractions with different polarities obtained from the leaves and stems of eight plant species. The toxic effect was evaluated on macrophages obtained from the bone marrow and peritoneal cavity of a Swiss webster mouse and J774 macrophages. G8 cell lineage. These macrophages were cultured in a 96-well plate, and the compounds were added at a concentration of 100 µg/mL for 24 hours. After this time, the supernatant was removed. The toxicity was evaluated for lactate dehydrogenase (LDH) release assay and the resazurin assay, which uses an indicator dye to measure oxidation-reduction reactions. The results showed a difference in the percentage of toxicity when comparing the same extract in different types of macrophages. This outcome indicates that these cells from different origins may exhibit different responses when exposed to the same natural compounds.

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Larvicidal activity of plants from Myrtaceae against Aedes aegypti L. and Simulium pertinax Kollar (Diptera)

Cited by 8 publications

References 28 publications

Chemical composition and larvicidal activity of the essential oil of Pimenta dioica leaves

Chemical composition and larvicidal activity of the essential oil of Pimenta dioica leaves

Larvicidal activity of cloves as an alternative to chemical control in mosquito vectors in the Amazonia under laboratory conditions

Comparative evaluation of plant extract effects on peritoneal, medullary and J774 cells. G8 macrophages

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