An unusual case of heart failure due to Plasmodium vivax infection with a favorable outcome

Dev, Nishanth; Gadpayle, Adesh Kumar; Sankar, Jhuma; Choudhary, Mona

doi:10.1590/0037-8682-0087-2014

Cited by 9 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…60,66,67,70 Five reports found decreased LVEF. 53,56,58,68,71 However, in four reports, 56,58,68,71 this normalized at follow-up (range 5-120 days). Most patients were diagnosed with myocarditis (n = 9) 53,56-60,68,70,71 and acute coronary syndrome (n = 4).…”

Section: Resultsmentioning

confidence: 90%

See 1 more Smart Citation

Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis

Gomes

Marinho

Silvestre

et al. 2021

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Recent studies have suggested that malaria may affect the cardiovascular system. The aim of this systematic review and meta-analysis was to determine the prevalence of cardiovascular complications in symptomatic malaria patients. We searched databases such as Pubmed, Embase, Cochrane, and Web of Science (January 1950–April 2020) for studies reporting on cardiovascular complications in adults and children with malaria. Cardiovascular complications were defined as abnormalities in electrocardiogram (ECG), cardiac biomarkers, and echocardiography on admission or during outpatient examination. Studies of patients with known heart disease or cardiovascular evaluation performed after the start of intravenous antimalarial medication were excluded. The study was registered in PROSPERO (No.: CRD42020167672). The literature search yielded 1,243 studies, and a total of 43 studies with symptomatic malaria patients were included. Clinical studies (n = 12 adults; n = 5 children) comprised 3,117 patients, of which a majority had Plasmodium falciparum (n = 15) and were diagnosed with severe malaria (n = 13). In random-effects models of adults, the pooled prevalence estimate for any cardiovascular complication was 7% (95% CI: 5–9). No meta-analysis was conducted in children, but the range of abnormal ECG was 0–8%, cardiac biomarkers 0–57%, and echocardiography 4–9%. We analyzed 33 cases (n = 10 postmortem), in which the most common cardiovascular pathologies were myocarditis and acute coronary syndrome. All histopathological studies found evidence of parasitized red blood cells in the myocardium. Cardiovascular complications are not uncommon in symptomatic adults and children with malaria. Additional studies investigating malaria and cardiovascular disease are encouraged.

show abstract

Section: Resultsmentioning

confidence: 90%

“…Adults. Abnormalities in ECG were present in 55% of cases, 48,50,53,56,58,60,[65][66][67]69,70 whereas 14% had increased troponins (TnT/TnI). 60,66,67,70 Five reports found decreased LVEF.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis

Gomes

Marinho

Silvestre

et al. 2021

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…However, there is the possibility of anti-malarial therapy being the cause of these cardiac complications [38–40]. …”

Section: Effects Of Malaria On Cardiac Musclementioning

confidence: 99%

The effect of malaria and anti-malarial drugs on skeletal and cardiac muscles

Marrelli

Brotto

2016

Malar J

View full text Add to dashboard Cite

Malaria remains one of the most important infectious diseases in the world, being a significant public health problem associated with poverty and it is one of the main obstacles to the economy of an endemic country. Among the several complications, the effects of malaria seem to target the skeletal muscle system, leading to symptoms, such as muscle aches, muscle contractures, muscle fatigue, muscle pain, and muscle weakness. Malaria cause also parasitic coronary artery occlusion. This article reviews the current knowledge regarding the effect of malaria disease and the anti-malarial drugs on skeletal and cardiac muscles. Research articles and case report publications that addressed aspects that are important for understanding the involvement of malaria parasites and anti-malarial therapies affecting skeletal and cardiac muscles were analysed and their findings summarized. Sequestration of red blood cells, increased levels of serum creatine kinase and reduced muscle content of essential contractile proteins are some of the potential biomarkers of the damage levels of skeletal and cardiac muscles. These biomarkers might be useful for prevention of complications and determining the effectiveness of interventions designed to protect cardiac and skeletal muscles from malaria-induced damage.

show abstract

“…Evidence of upregulated gene expression of cardiomyocytes related to apoptosis and myocardial damage treated with purified P. falciparum glycosyl phosphatidylinositol (a toxin in malaria pathogenesis) suggests P. falciparum can induce apoptosis [176]. Case reports and rodent models also describe acute coronary syndrome, tachycardia, arrhythmias and myocardial failure in malaria patients [177][178][179][180].…”

Section: Diagnosismentioning

confidence: 99%

Parasitic (Protozoan) cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management

Albakri¹

2019

Res Rev Insights

View full text Add to dashboard Cite

Human parasitic infections constitute a substantial but neglected disease burden. Protozoa and helminths are two parasites groups known to be pathogenic to the human heart. Trypanosoma cruzi, Trypanosoma brucei, toxoplasma, plasmodium and Leishmania are the most frequent protozoa that can establish infections in human resulting in a wide spectrum of cardiac manifestations. The involvement of the myocardium can manifest as protozoan cardiomyopathy in many resource-constrained countries. However, at present, resource-rich countries are encountering diagnoses of parasitic infections with cardiac involvement attributable to increasing travel and migration, blood transfusions, growing numbers of immunodeficient patients -a worldwide epidemic of acquired immunodeficiency syndrome (HIV/AIDS), and increasing transplant recipients and use of immunosuppressive agents. Clinicians across the globe need to be aware of the potential cardiac involvement after parasitic infection in vulnerable individuals and in endemic areas. This paper reviews published evidence on protozoal parasites that can infect the myocardium, including the pathophysiology, diagnosis and management of protozoan cardiomyopathy. The paper also highlights areas of limited knowledge that could benefit from additional research.

show abstract

An unusual case of heart failure due to Plasmodium vivax infection with a favorable outcome

Cited by 9 publications

References 11 publications

Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis

Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis

The effect of malaria and anti-malarial drugs on skeletal and cardiac muscles

Parasitic (Protozoan) cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management

Contact Info

Product

Resources

About