New sequence types of Acinetobacter baumannii in two emergency hospitals in the Central-West region of Brazil

Azevedo, Francisco Kennedy Scofoni Faleiros de; Dutra, Valéria; Nakazato, Luciano; Pepato, Marco Andrey; Sousa, Alessandra Tammy Hayakawa Ito de; Azevedo, Cassius Clay Scofoni Faleiros de; Souto, Francisco José Dutra

doi:10.1590/0037-8682-0077-2019

Cited by 7 publications

(6 citation statements)

References 9 publications

(5 reference statements)

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“…Numerous epidemiological studies of A. baumannii associate it with the presence of ST by local origin, as seen in the occurrence of ST 848 (CC 208) (Oxford scheme) carrying resistance gene to carbapenems in India [ 18 ], and likewise the frequent presence of ST15, ST25, ST79, and ST1 in South America [ 19 , 20 ]. A recent phylogeographical analysis of the Italian isolates belongs to the only clonal group ST78 (Pasteur scheme) [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

Pan-Resistome Insights into the Multidrug Resistance of Acinetobacter baumannii

et al. 2021

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Acinetobacter baumannii is an important Gram-negative opportunistic pathogen that is responsible for many nosocomial infections. This etiologic agent has acquired, over the years, multiple mechanisms of resistance to a wide range of antimicrobials and the ability to survive in different environments. In this context, our study aims to elucidate the resistome from the A. baumannii strains based on phylogenetic, phylogenomic, and comparative genomics analyses. In silico analysis of the complete genomes of A. baumannii strains was carried out to identify genes involved in the resistance mechanisms and the phylogenetic relationships and grouping of the strains based on the sequence type. The presence of genomic islands containing most of the resistance gene repertoire indicated high genomic plasticity, which probably enabled the acquisition of resistance genes and the formation of a robust resistome. A. baumannii displayed an open pan-genome and revealed a still constant genetic permutation among their strains. Furthermore, the resistance genes suggest a specific profile within the species throughout its evolutionary history. Moreover, the current study performed screening and characterization of the main genes present in the resistome, which can be used in applied research to develop new therapeutic methods to control this important bacterial pathogen.

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Section: Resultsmentioning

confidence: 99%

Pan-Resistome Insights into the Multidrug Resistance of Acinetobacter baumannii

et al. 2021

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“…No Brasil, juntamente com o IC1, há prevalência dos CC15 e CC79 de Azevedo et al, 2019;, conhecidos como clones de alto risco (Medeiros e Lincopan, 2013).…”

Section: Para Identificação Das Oxacilinases Presentes Em Cepas Deunclassified

“…De acordo com estudos recentes, o CC79 é considerado o complexo clonal mais disseminado em nosso país (de Azevedo et al, 2019;. Em um estudo realizado por da Silva e colaboradores (2018) (Bartual et al, 2005).…”

Section: Para Identificação Das Oxacilinases Presentes Em Cepas Deunclassified

Caracterização fenotípica e molecular da resistência antimicrobiana e relação genética em isolados clínicos de clones de alto risco de Acinetobacter baumannii

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“…Estudos publicados no Brasil nos últimos anos citam o surgimento de novos STs, como ST25, ST981, ST982, ST986 (de Azevedo et al, 2018), ST984, ST985 e ST987, fator preocupante devido a ampla resistência desse patógeno (de Azevedo et al, 2019).…”

Section: Polimixinasunclassified

Análise genômica e caracterização da suscetibilidade antimicrobiana em clones emergentes de Acinetobacter baumannii resistentes aos carbapenêmicos provenientes de diferentes instituições brasileiras

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New sequence types of Acinetobacter baumannii in two emergency hospitals in the Central-West region of Brazil

Cited by 7 publications

References 9 publications

Pan-Resistome Insights into the Multidrug Resistance of Acinetobacter baumannii

Pan-Resistome Insights into the Multidrug Resistance of Acinetobacter baumannii

Caracterização fenotípica e molecular da resistência antimicrobiana e relação genética em isolados clínicos de clones de alto risco de Acinetobacter baumannii

Análise genômica e caracterização da suscetibilidade antimicrobiana em clones emergentes de Acinetobacter baumannii resistentes aos carbapenêmicos provenientes de diferentes instituições brasileiras

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