Factors associated with deaths from dengue in a city in a metropolitan region in Southeastern Brazil: a case-control study

Sousa, Selma Costa de; Silva, Thaís Almeida Marques da; Soares, Aleida Nazareth; Carneiro, Mariângela; Barbosa, David Soeiro; Bezerra, Juliana Maria Trindade

doi:10.1590/0037-8682-0043-2022

Rev. Soc. Bras. Med. Trop.

2022

DOI: 10.1590/0037-8682-0043-2022

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Factors associated with deaths from dengue in a city in a metropolitan region in Southeastern Brazil: a case-control study

Selma Costa de Sousa

Thaís Almeida Marques da Silva²,

Aleida Nazareth Soares³

et al.

Abstract: JMTB contributed to the conception, design of the study, analysis and writing of the article. TAMS and ANS contributed to the statistical analysis and writing of the article. SCS and JMTB contributed to the planning and design of the study; writing, review and final approval of the article. All authors have approved the final version to be published and are responsible for all aspects of the research, including ensuring its accuracy and integrity.

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2024

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Risk factors associated with severe dengue in Latin America: A systematic review and meta‐analysis

Paraná,

Feitosa,

da Silva

et al. 2024

Tropical Med Int Health

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ObjectiveSevere dengue is a significant health problem in Latin America, with children being the most affected. Understanding risk factors for severe dengue is crucial for enhancing patient care. Therefore, this study aims to systematically review the literature to identify the risk factors associated with severe dengue in Latin America through systematic review and meta‐analysis.MethodsPubMed, SciELO, LILACS and EMBASE databases were used to search for eligible scientific articles for the review. The outcomes considered were symptoms of severe dengue, hospitalisation and death. The Joanna Briggs Institute Critical Appraisal Checklist was used to assess the quality of the studies. Data analysis was performed using STATA v 13.0 software. The degree of heterogeneity between studies was quantified using the I2 measure, and statistically significant results were defined as those with p values <0.05.ResultsOf the 1876 articles screened, 47 articles were included in the systematic review and 45 articles were analysed through meta‐analysis. Identified risk factors associated with severe dengue included secondary dengue infection, female sex, white or Caucasian ethnicity and specific signs and symptoms such as headache, myalgia and/or arthralgia, vomiting/nausea, abdominal pain or tenderness, diarrhoea, prostration, lethargy, fatigue or similar. For the death outcome, respiratory symptoms and age <18 years were identified as risk factors. On the other hand, in women, the diagnosis of positive tourniquet test, platelet count <100,000 per μL and symptoms of capillary fragility were associated with a lower probability of death. These data highlight the importance of early screening of patients, to identify possible haemorrhagic signs and reduce deaths from dengue. This study has limitations, including possible publication bias, heterogeneity of results and study design biases.ConclusionThese findings are significant for shaping strategies, management approaches and identifying high‐risk groups, which will help establish future guidelines.

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Risk factors associated with severe dengue in Latin America: A systematic review and meta‐analysis

Paraná,

Feitosa,

da Silva

et al. 2024

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

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Factors associated with deaths from dengue in a city in a metropolitan region in Southeastern Brazil: a case-control study

Cited by 1 publication

References 15 publications

Risk factors associated with severe dengue in Latin America: A systematic review and meta‐analysis

Risk factors associated with severe dengue in Latin America: A systematic review and meta‐analysis

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