Analysis of clinical cure outcome, macrophages number, cytokines levels and expression of annexin-A1 in the cutaneous infection in patients with Leishmania braziliensis
Joselina Maria da Silva,
Helen Aguiar Lemes da Silva,
Ana Lucia Carneiro Sarmento
et al.
Abstract:Background:
Leishmania braziliensis
, a protozoan prevalent in Brazil,
is the known causative agent of cutaneous leishmaniasis (CL). The activation
of M1 macrophages is a pivotal factor in the host's ability to eliminate the
parasite, whereas M2 macrophages may facilitate parasite proliferation. This
study analyzed the clinical outcomes of CL and the patients' immunological
profiles, focusing on the prevalence of M1 and M2 macrophages, cytokine
production, and annexin-A1 (ANXA1) exp… Show more
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