Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni

Drummond, Sandra; Pereira, Pedro Nunes; Otoni, Alba; Chaves, Bruna Assis; Antunes, Carlos; Lambertucci, José Roberto

doi:10.1590/0037-8682-0020-2014

Cited by 11 publications

(11 citation statements)

References 29 publications

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“…Among the cytopenias observed, plateletopenia was the most common, followed by leukopenia and anemia. These findings were also reported in other studies [24][25][26][27][28][29][30] .…”

Section: ■ Discussionsupporting

confidence: 91%

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

et al. 2018

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Purpose: To evaluate a possible relationship between the size of the spleen and values of circulating blood elements in patients with schistosomatic splenomegaly. Methods: Sixty one patients with hepatosplenic schistosomiasis mansoni underwent a clinical exam and peripheral venous blood was collected for a hemogram. The erythrocyte, hemoglobin, hematocrit, leukocyte, and platelet values were determined. All patients underwent abdominal ultrasound to measure the spleen. The hematological test results were compared to the size of the spleen. Results: The size of the spleen varied from 14.0 to 28.4 (19.9 ± 3.7) cm according to the ultrasound image. Thrombocytopenia was observed 58 (95%) patients, leukopenia in 55 (90%) patients, and anemia in 32 (52.4%) patients. Leukopenia was proportional to splenomegaly. Conclusion: Schistosomal splenomegaly leads to leukopenia in direct proportion to the size of the spleen.

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“…Among the cytopenias observed, plateletopenia was the most common, followed by leukopenia and anemia. These findings were also reported in other studies [24][25][26][27][28][29][30] .…”

Section: ■ Discussionsupporting

confidence: 91%

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

et al. 2018

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“…In the end, thrombocytopenia was, in fact, associated with NAFLD. A possible explanation for disagreement is that the association of thrombocytopenia with hepatosplenic schistosomiasis previously occurred in highly endemic areas, 6 while, presently, our investigation was performed in an area of low prevalence (8%) and low morbidity (two patients with hepatosplenic schistosomiasis). We conclude that thrombocytopenia is a good marker of liver steatosis in this lowly endemic area for schistosomiasis.…”

Section: Discussionmentioning

confidence: 84%

“…3 However, the identification of other non-invasive, inexpensive, and simple routine laboratory tests for use as surrogate markers is of interest. [4][5][6] Recently, thrombocytopenia has been shown to identify hepatosplenomegaly in Schistosoma-endemic areas and is a promising marker of hepatosplenic schistosomiasis mansoni. Drummond et al, working in an area of moder-ate to high endemicity, showed that thrombocytopenia (platelets < 143,000/mm 3 ) separated individuals with and without hepatosplenic schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

“…Drummond et al, working in an area of moder-ate to high endemicity, showed that thrombocytopenia (platelets < 143,000/mm 3 ) separated individuals with and without hepatosplenic schistosomiasis. 6 Liver steatosis (also called fatty liver) refers to the abnormal retention of lipids within a cell. Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide with prevalence estimates ranging from 25 to 45% in most studies.…”

Section: Introductionmentioning

confidence: 99%

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Thrombocytopenia as a marker of liver steatosis in a low-endemic area for schistosomiasis mansoni

Otoni

Antunes

Tavares

et al. 2017

Rev. Assoc. Med. Bras.

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Summary Introduction: Thrombocytopenia is commonly found in patients living in highly endemic areas for Schistosoma mansoni. Recently, different degrees of liver steatosis have also been associated with low platelet counts worldwide. We investigated the association of platelet counts with hepatosplenic schistosomiasis and with liver steatosis in an area of low prevalence of schistosomiasis in Brazil. Method: Pains, a city in the state of Minas Gerais, Brazil, had a population of 8,307 inhabitants and a schistosomiasis prevalence of 8%. Four micro-areas comprising 1,045 inhabitants were selected for this study. Blood sample was collected and a complete blood count (CBC) was performed. Eighty-seven (87) patients had low platelet counts (group 1 - 8.3%) and 94 volunteers presenting normal CBC were randomized (group 2 - 8.9%). They underwent clinical and ultrasound examinations. Liver steatosis was determined as either present or absent using abdominal ultrasound. A spleen > 12 cm in length, measured by ultrasound (US), was considered to be increased. Data collected were analyzed using SPSS software version 19.0. Results: Twenty-two patients (22/25.3%) in group 1 had liver steatosis compared with 11 volunteers (11.7%) in group 2 (p=0.02). Hepatosplenic schistosomiasis was diagnosed in two patients (p>0.05). Conclusion: Thrombocytopenia was not a good marker of hepatosplenic schistosomiasis mansoni in a low prevalence area in Brazil. Liver steatosis was associated with thrombocytopenia in our study.

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“…All participants tested within the normal range. Platelet counts below 143,000cell/mm 3 were shown to predict hepatosplenic schistosomiasis in an endemic area with a prevalence of 23% 19 . However, the accuracy of low platelet count to identify hepatosplenic schistosomiasis in lower prevalence areas is unknown.…”

Section: Discussionmentioning

confidence: 94%

Morbidity of schistosomiasis mansoni in a low endemic setting in Ouro Preto, Minas Gerais, Brazil

Marinho

Grobério

Silva

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Despite the advances of disease control programs, severe forms of schistosomiasis are prevalent. The prevalence of the disease in areas frequented by tourists urges for permanent prevention and control. The aim of this study was to describe the morbidity of schistosomiasis in the district of Antônio Pereira, Ouro Preto, Minas Gerais, Brazil. Methods: The proportion of positives was defined by Kato-Katz coproscopy and urinary POC-CCA rapid test. Hepatosplenic form was diagnosed using abdominal ultrasound. Results: Out of 180 participants,97 were examined by Kato-Katz, with 4 (4.1%) being positive. Thirtyfour (22.1%) out of 154 were positive by POC-CCA. Five (2.8%) of 177 examined by ultrasound had hepatosplenic form. One of them had undergone splenectomy. One (0.6%)participant had myeloradiculopathy. Conclusions: Severe forms of schistosomiasis are still prevalent in low endemic areas and should be thoroughly investigated.

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Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni

Cited by 11 publications

References 29 publications

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly

Thrombocytopenia as a marker of liver steatosis in a low-endemic area for schistosomiasis mansoni

Morbidity of schistosomiasis mansoni in a low endemic setting in Ouro Preto, Minas Gerais, Brazil

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