Colonização nasal em profissionais de enfermagem de unidades especializadas em HIV/aids

Reinato, Lilian Andreia Fleck; Pereira, Fernanda Maria Vieira; Lopes, Letícia Pimenta; Pio, Daiana Patrícia Marchetti; Gir, Elucir

doi:10.1590/0034-7167.2015680119i

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…11 It has been reported that nasal colonization by Staphylococcus aureus affects 20-30% of healthy individuals. 12 However, because of a weakened immune response, a pharmacologically suppressed immune system, or nasal mucosal contact with bacteria not recognized by the immune system ('not self', in immunology), bacterial proliferation is favored, allergic or non-allergic immune responses are activated, and inflammatory mediators like histamine and prostaglandins are released. This induces inflammatory cell recruitment, vasodilation, increased local permeability, and activation of goblet cells.…”

Section: Intranasal Drug Delivery Devices Are a Potential Contaminatimentioning

confidence: 99%

Intranasal drug delivery devices are a potential contamination source of airways

Pereira¹,

Soares²,

Innocencio³

et al. 2019

Brazilian Journal of Allergy and Immunology (BJAI)

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Background: The use of intranasal drug delivery devices (IDDD) for the treatment of allergic rhinitis (AR) is frequent because they are simple, efficient, and safe, and mainly because they are perceived as low-risk. However, it is speculated that contact between the nasal mucosa and an IDDD may give rise to infections once the nose is colonized by bacteria, and there are currently no proper instructions for IDDD sanitization. The objective of this study was to evaluate the possibility of contamination of an IDDD for topical medication after simulating use in healthy individuals. Methods: The in vitro study consisted of 14 healthy individuals of both sexes, between the ages of 18 and 24 years. Samples were collected immediately after the opening of each IDDD and after simulating use by the subjects. Afterwards, the samples were deposited in tubes and kept in an incubator at 37 °C. After 48 hours, the samples were inoculated on Müller-Hinton agar. Qualitative analyses of the appearance of the samples were performed after 24 and 48 hours, and after 72 hours the presence or absence of bacteria was evaluated macroscopically. Results: After 24 hours of incubation, 21.4% (n = 3) of the samples presented with a turbid appearance and after 48h, 71% (n = 10) of the samples presented with a turbid appearance and positive bacterial growth. Conclusion: The results suggest that IDDDs for topical medications may be important sources of contamination or recontamination of the nasal mucosa of individuals who are being treated for upper respiratory tract conditions. A better understanding of the risks of re-using IDDDs after previous contact with the nasal mucosa will improve guidelines on hygiene procedures and prevention of related risks.

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Section: Intranasal Drug Delivery Devices Are a Potential Contaminatimentioning

confidence: 99%

Intranasal drug delivery devices are a potential contamination source of airways

Pereira¹,

Soares²,

Innocencio³

et al. 2019

Brazilian Journal of Allergy and Immunology (BJAI)

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The History of Methicillin-Resistant Staphylococcus aureus in Brazil

Andrade

Luiz

Souza

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Since the emergence of MRSA in the 1960s, a gradual increase in infections by resistant bacteria has been observed. Clinical manifestations may vary from brand to critical condition due to host risk factors, as well as pathogen virulence and resistance. The high adaptability and pathogenic profile of MRSA clones contributed to its spread in hospital and community settings. In Brazil, the first MRSA isolates were reported in the late 1980s, and since then different genetic profiles, such as the Brazilian epidemic clone (BEC) and other clones considered a pandemic, became endemic in the Brazilian population. Additionally, Brazil’s MRSA clones were shown to be able to transfer genes involved in multidrug resistance and enhanced pathogenic properties. These events contributed to the rise of highly resistant and pathogenic MRSA. In this review, we present the main events which compose the history of MRSA in Brazil, including numbers and locations of isolation, as well as types of staphylococcal cassette chromosome mec (SCCmec) found in the Brazilian territory.

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<i>Staphylococcus aureus</i> em profissionais de enfermagem e as interfaces com a adesão às precauções-padrão

Lopes¹

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Colonização nasal em profissionais de enfermagem de unidades especializadas em HIV/aids

Abstract: Staphylococcus aureus microorganism accounted for the largest prevalence in individuals of this study.

Cited by 6 publications

References 13 publications

Intranasal drug delivery devices are a potential contamination source of airways

Intranasal drug delivery devices are a potential contamination source of airways

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

<i>Staphylococcus aureus</i> em profissionais de enfermagem e as interfaces com a adesão às precauções-padrão

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