Use of vitamin D and infection in patients with chronic kidney disease

Abstract

Objective: To evaluate the effectiveness of vitamin D supplementation as protection factor against infection of patients with chronic kidney disease on conservative treatment. Method: Retrospective cohort study carried out between 2013 and 2016 in the Conservative Treatment Outpatient Clinics (Ambulatório de Tratamento Conservador) of the Hypertension and Kidney Hospital (Hospital do Rim e Hipertensão) of the Universidade Federal de São Paulo. Data on sociodemographic factors, comorbidity, infection episodes and use or nonuse of vitamin D supplementation for at least 6 months were collected from medical records. The primary outcomes considered in both groups were: presence or absence of infection anywhere on the body (bloodstream, urinary, respiratory and surgical sites). Results: A total of 263 patients were included and those who received (n=43) vitamin D had 59% less chance of developing infections (OR=0.41; 95%CI; 0.15-0.99), when compared to those who did not receive. Conclusion: Vitamin D supplementation was a protective factor against infections of all causes.

Urinary tract infection in patients with chronic kidney disease under conservative treatment

“…This study was carried out at the Conservative Treatment Outpatient Clinic, which predominantly assists adults and elderly (mostly aged 50 or over), male, whose main causes are CKD, HP and DM. Regarding the staging of CKD, most patients seen are in stages 3, 4 and 5 of CKD, and due to the high demand and demand for the service, patients in stages 1 and 2 are advised to seek the primary health network (7) .…”

“…Chronic renal patients, uremic or not, are considered immunocompromised, and the infection is an important cause of death in patients with CKD, in whom the cellular immune function is depressed (6) . Furthermore, CKD is a risk factor for the decrease in vitamin D levels, which also favors the appearance of infectious diseases (7) .…”