Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis

Abstract

Objective: To identify biomarkers for Parkinson’s disease, cerebrospinal fluid, blood, saliva, and urine. Method: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3. Results: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson’s disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment. Conclusion: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.

A Pilot Study of Changes in the Level of Catecholamines and the Activity of α-2-Macroglobulin in the Tear Fluid of Patients with Parkinson’s Disease and Parkinsonian Mice

“…The main trend in the development of an early and differential diagnosis of PD is the search for biomarkers as changes in the level of certain substances in the body fluids, mainly in the blood and cerebrospinal fluid. However, data published by various authors are often contradictory [ 14 , 17 , 38 , 39 , 40 , 41 , 42 , 43 , 46 , 47 , 48 ]. This is probably due to the fact that the concentration of analytes in the blood and, to a lesser extent, in the cerebrospinal fluid is an integral index of a wide range of metabolic processes associated with degeneration and plasticity of central and peripheral neurons, as well as desympathization of the internal organs [ 8 , 20 ].…”