Post-COVID-19 Syndrome? New daily persistent headache in the aftermath of COVID-19

Liu, Jonathan Wei Ting Wen; Luca, Renata D'altoé de; Neto, Heraldo Oliveira Mello; Barcellos, Igor

doi:10.1590/0004-282x20200187

Cited by 18 publications

(15 citation statements)

References 5 publications

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“…Indeed, post-COVID related headache in those patients without previous headache history could emerge as a new persistent headache of post-infectious aetiology. This pattern of emergence could meet criteria for new daily persistent headache (NDPH), which is daily and unremitting from its onset ( 30 , 31 ). Remarkably, other past viral outbreaks also provoked daily persistent headache ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

The presence of headache at onset in SARS-CoV-2 infection is associated with long-term post-COVID headache and fatigue: A case-control study

Fernández‐de‐las‐Peñas

Gómez‐Mayordomo

Cuadrado

et al. 2021

Cephalalgia

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Objective To investigate the association of headache during the acute phase of SARS-CoV-2 infection with long-term post-COVID headache and other post-COVID symptoms in hospitalised survivors. Methods A case-control study including patients hospitalised during the first wave of the pandemic in Spain was conducted. Patients reporting headache as a symptom during the acute phase and age- and sex-matched patients without headache during the acute phase participated. Hospitalisation and clinical data were collected from medical records. Patients were scheduled for a telephone interview 7 months after hospital discharge. Participants were asked about a list of post-COVID symptoms and were also invited to report any additional symptom they might have. Anxiety/depressive symptoms and sleep quality were assessed with the Hospital Anxiety and Depression Scale and the Pittsburgh Sleep Quality Index. Results Overall, 205 patients reporting headache and 410 patients without headache at hospitalisation were assessed 7.3 months (Standard Deviation 0.6) after hospital discharge. Patients with headache at onset presented a higher number of post-COVID symptoms (Incident Rate Ratio: 1.16, 95% CI: 1.03–1.30). Headache at onset was associated with a previous history of migraine (Odd Ratio: 2.90, 95% Confidence Interval: 1.41–5.98) and with the development of persistent tension-type like headache as a new post-COVID symptom (Odd Ratio: 2.65, 95% CI: 1.66–4.24). Fatigue as a long-term symptom was also more prevalent in patients with headache at onset (Odd Ratio: 1.55, 95% CI: 1.07–2.24). No between-group differences in the prevalence of anxiety/depressive symptoms or sleep quality were seen. Conclusion Headache in the acute phase of SARS-CoV-2 infection was associated with higher prevalence of headache and fatigue as long-term post-COVID symptoms. Monitoring headache during the acute phase could help to identify patients at risk of developing long-term post-COVID symptoms, including post-COVID headache.

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Section: Discussionmentioning

confidence: 99%

The presence of headache at onset in SARS-CoV-2 infection is associated with long-term post-COVID headache and fatigue: A case-control study

Fernández‐de‐las‐Peñas

Gómez‐Mayordomo

Cuadrado

et al. 2021

Cephalalgia

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“…Aunque no está adecuadamente delimitada, se sugiere que podría ser similar a la cefalea crónica persistente de novo. Es una cefalea continua, holocraneal y habitualmente no se acompaña de náuseas, vómitos, fono ni fotofobia [46][47][48][49][50].…”

Section: ¿Cuáles Son Las Manifestaciones Neurológicas Del Síndrome Post-covid?unclassified

Post-COVID syndrome: A reflection and opinion paper

Bouza

Moreno²,

Ramos³

et al. 2021

Rev Esp Quimioter

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A high proportion of people who have suffered from COVID-19 report, after recovery from the acute phase of the disease, clinical manifestations, both subjective and objective, that continue beyond 3 weeks or even 3 months after the original clinical disease. There is still no agreed nomenclature to refer to this condition, but perhaps the most commonly used is post-COVID syndrome. The Scientific Committee on COVID of the Madrid College of Physicians (ICOMEM) has discussed this problem with a multidisciplinary approach in which internists, infectious disease specialists, psychiatrists, pneumologists, surgeons, geriatricians, pediatricians, microbiologists, family physicians and other specialists have participated, trying to gather the existing information and discussing it in the group. The clinical manifestations are very variable and range from simple fatigue to persistent fibrosing lung lesions with objective alterations of pulmonary function. Post-COVID syndrome seems to be particularly frequent and severe in adults who have required admission to Intensive Care Units and has a peculiar behavior in a very small group of children. The post-COVID syndrome, which undoubtedly exists, is at first sight not clearly distinguishable from clinical manifestations that which occur after other acute viral diseases and after prolonged stays in ICUs due to other diseases. Therefore, it offers excellent research opportunities to clarify its pathogenesis and possibly that of other related entities. It is possible that progressively there will be an increased demand for care among the millions of people who have suffered and overcome acute COVID for which the health authorities should design mechanisms for the agile management of care that will possibly require well-coordinated multidisciplinary groups. This paper, structured in questions on different aspects of the post-COVID syndrome, attempts to stage the current state of this problem

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“…Headache is a very frequently reported symptom among patients with COVID-19, and recently, cases of persistent headache have been reported even weeks after recovery from the disease. This type of headache meets the diagnostic criteria for new daily persistent headache (NDPH) and has been reported to have holocranial, pressure-like pain characteristics that start within 2 weeks after SARS-CoV-2 infection, especially in outpatients without a preexisting primary headache diagnosis ( Liu et al, 2020 ). In a previous study, 37.8% of patients who experienced headache in the acute phase of their SARS-CoV-2 infection were reported to develop persistent headache, and 60.7% of these patients met the NDPH criteria ( Caronna et al, 2020 ).…”

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confidence: 99%

Is Increased Intracranial Pressure a Factor in Persistent Headache After Coronavirus Disease 2019?

et al. 2021

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This study aimed to determine pain characteristics in patients with persistent headache after COVID-19 and to investigate the role of increased intracranial pressure (ICP) in the pathogenesis of this headache. This is a case-control study comparing the parameters and measurements indicating increased ICP based on magnetic resonance imaging between COVID-19–diagnosed patients with persistent headache and a control group. Optic nerve sheath diameter (ONSD) and eyeball transverse diameter (ETD) were performed on the left eye of each participant. Seventeen of the patients (53.12%) met the diagnostic criteria for new daily persistent headache. Seven patients (21.87%) had migraine, and eight (25%) had tension headache characteristics. No significant difference was observed between the patient and control groups in terms of the ONSD and ETD values. It is possible that the etiopathogenesis is multifactorial. We consider that future studies that will evaluate ICP measurements in large patient groups can present a different perspective for this subject.

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Post-COVID-19 Syndrome? New daily persistent headache in the aftermath of COVID-19

Cited by 18 publications

References 5 publications

The presence of headache at onset in SARS-CoV-2 infection is associated with long-term post-COVID headache and fatigue: A case-control study

The presence of headache at onset in SARS-CoV-2 infection is associated with long-term post-COVID headache and fatigue: A case-control study

Post-COVID syndrome: A reflection and opinion paper

Is Increased Intracranial Pressure a Factor in Persistent Headache After Coronavirus Disease 2019?

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