Facial palsy as a neurological complication of SARS-CoV-2

Ribeiro, Bruno Niemeyer de Freitas; Marchiori, Edson

doi:10.1590/0004-282x20200127

Cited by 17 publications

(15 citation statements)

References 3 publications

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“…In total, our search strategy revealed 215 articles (Figure 1, Table 2). After excluding duplicates and those not meeting inclusion criteria, a total of 32 papers were included in the current review with 46 patients, with an equal number ( n = 23) of males and females [11–42]. The maximum number of cases were from Brazil ( n = 9) and Turkey ( n = 9), followed by the United States ( n = 8), Iran ( n = 4), and Spain ( n = 3).…”

Section: Resultsmentioning

confidence: 99%

Surge of Bell's Palsy in the era of COVID‐19: Systematic review

Gupta

Jawanda²

2022

Euro J of Neurology

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Background and purpose With the progression of coronavirus infectious disease 2019 (COVID‐19), various neurological manifestations have been noticed in infected patients, and Bell's Palsy (BP) is one of the peripheral neuropathies among those. BP has been associated with various other viral agents. Its evidence in patients with COVID‐19 signifies the possibility of association between BP and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). This research was undertaken to evaluate the number of published cases of BP as the only major neurological manifestation in patients with COVID‐19 from March 2020 to December 2021 and to investigate the association of SARS‐CoV‐2 and BP. Methods A systematic review of the published English literature was performed using an electronic search in the PubMed/Medline, Scopus, Research Gate, Research Square, and Google Scholar databases, using keywords such as "COVID‐19" OR/AND "SARS‐CoV‐2" OR/AND "Bell's palsy" OR/AND "facial nerve palsy" OR/AND "neurological" OR/AND "manifestation". Results The search strategy revealed 32 relevant publications with a total of 46 patients. BP was the initial manifestation in 37% of cases, and in 63% of cases it developed after COVID‐19 symptoms; 71.7% of cases showed complete recovery, and 21.7% showed only partial relief from BP. Conclusions Although the number of documented cases in this research is low, evidence of BP as the only major neurological manifestation in patients with COVID‐19 signifies an important clinical finding and the possibility of another viral etiology of BP. More evidence is needed to establish the exact correlation between these two entities.

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Section: Resultsmentioning

confidence: 99%

Surge of Bell's Palsy in the era of COVID‐19: Systematic review

Gupta

Jawanda²

2022

Euro J of Neurology

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“…Studies on the increase in acute peripheral facial palsy during the COVID-19 pandemic have been published. Direct viral neurophysics or an immune mechanism secondary to elevated pro-inflammatory cytokines can cause facial palsy in COVID-19 [18][19][20][21][22][23] .…”

Section: Resultsmentioning

confidence: 99%

Evidence for facial nerve palsy and SARS-CoV-2

Teles

Carneiro²,

Pestana³

2021

Rev Neurocienc

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Introduction. The World Health Organization (WHO) has recognized a new strain of coronavirus, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), called Coronavirus Disease 2019 (COVID-19). The mildest and most common symptoms include fever, fatigue and cough; however, more severe cases of the disease can cause breathing difficulties, kidney and heart failure and, eventually, death. However, an increasing number of reports of neurological manifestations have emerged. Objective. Provide a comprehensive review of the neurological manifestations of SARS-CoV-2 and especially the relationship between acute facial nerve palsy and COVID-19, as well as their results in mortality and the implications that this has in clinical practice. Method. The search in seven databases (PubMed, Cochrane Library, Lilacs, Scielo, Web of Science, Scopus and Google Scholar) was carried out by two independent reviewers in search of evidence of Facial Nerve Palsy (VII) and SARS-CoV-2 . After screening, data were collected and discussed. Results. Idiopathic facial palsy is called Bell's palsy and studies have shown that facial palsy increased during the COVID-19 pandemic period. There are many reports on the relationship between COVID-19 and facial paralysis, but little real evidence of their relationship. Conclusion. It is still questionable whether these neuroimmune disorders occur directly from viral infection or as autoimmune sequelae. The pathogenesis of the disease behind this manifestation is not yet fully understood. We believe that more research should be carried out to clarify the association raised by this study.

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“…Another case is a pregnant patient reported by Figueiredo et al [ 13 ]. Ribeiro and Marchiori also reported a 26-year-old male patient [ 36 ]. Goh et al presented a case of peripheral facial paralysis that developed on the sixth day of COVID-19 disease in a 27-year-old male patient [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…and Marchiori also reported a 26-year-old male patient[36]. Goh et al presented a case of peripheral facial paralysis that developed on the sixth day of COVID-19 disease in a 27-year-old male patient[10].Muras et al also reported a patient with bilateral facial palsy who presented evidence of SARS-CoV-2 infection and coinfection with Epstein-Barr virus[37].…”

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confidence: 98%

Can COVID-19 Cause Peripheral Facial Nerve Palsy?

Eğilmez

Gündoğan

Yılmaz

et al. 2021

SN Compr. Clin. Med.

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The aim of our study is to evaluate the relationship between peripheral facial paralysis and the patients who had a contact with a coronavirus disease 2019 (COVID-19) patient or had COVID-19. Patients with a history of contact with a COVID-19 patient or having COVID-19 disease, who were admitted to the emergency department for peripheral facial paralysis in the last 6 months, were included in the study. Facial paralysis grade at first presentation, treatment modality, treatment duration, post-treatment facial paralysis grade, and additional findings were analyzed. A total of 34 patients, 20 females and 14 males, were included into the study. Nasal-oropharyngeal reverse transcriptase-polymerase chain reaction (RT-PCR) was test taken from patients with a history of contact, and patients having COVID-19 disease were determined as positive in 5 and 3 patients, respectively. Peripheral facial paralysis was detected as an initial finding in 5 of these 8 patients, and paralysis developed in 7-12 days after the diagnosis of the COVID-19 disease in the remaining 3 patients. The grade of first admission paralysis did not change in one patient in the (+) group, while improvement was observed in all patients in the (−) group. Neuroinvasive potential of COVID-19 in the central and peripheral nervous system was reported in current literature. Our study indicates peripheral facial palsy can also be encountered during the clinical course of COVID-19 and should be considered a finding of this disease.

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Facial palsy as a neurological complication of SARS-CoV-2

Cited by 17 publications

References 3 publications

Surge of Bell's Palsy in the era of COVID‐19: Systematic review

Surge of Bell's Palsy in the era of COVID‐19: Systematic review

Evidence for facial nerve palsy and SARS-CoV-2

Can COVID-19 Cause Peripheral Facial Nerve Palsy?

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