Cognitive performance in chronic migraine

Martins, Isabel Pavão

doi:10.1590/0004-282x20200024

Cited by 5 publications

(5 citation statements)

References 17 publications

(11 reference statements)

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“…The chronic conditions that are risk factors for cognitive impairment include diabetes (23), hypertension (24), cardiac diseases (25), major depressive disorder (26), peripheral vascular disease (27), kidney disease (28), and thyroid dysfunction (29). We did not expect the CII to be associated with allergies (30), arthritis (31), migraines (32), osteoporosis (33), history of cancer (34), ulcers, or back pain. We had no a priori hypotheses for bowel or urinary incontinence because these are features of advanced neurological conditions, and the cognitive consequences for these as stand-alone conditions is not well-studied.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment Indicator for the Neuropsychological Test Batteries in the Canadian Longitudinal Study on Aging: Definition and Evidence for Validity

O’Connell

Kadlec

Griffith

et al. 2022

Preprint

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BACKGROUND: Prevalence of overall cognitive impairment based on each participant’s performance across a neuropsychological battery is challenging; consequently, we define and validate a dichotomous cognitive impairment/no cognitive indicator (CII) using a neuropsychological battery administered in a population-based study. This CII approximates the clinical practice of interpretation across a neuropsychological battery and can be applied to any neuropsychological dataset. METHODS: Using data from participants aged 45-85 in the Canadian Longitudinal study on Aging receiving a telephone-administered neuropsychological battery (Tracking, N = 21,241) or a longer in-person battery (Comprehensive, N = 30,097), impairment was determined for each neuropsychological test based on comparison with normative data. We adjusted for the joint probability of abnormally low scores on multiple neuropsychological tests using baserates of low scores demonstrated in the normative samples, and created a dichotomous CII (i.e., cognitive impairment vs no cognitive impairment). Convergent and discriminant validity of the CII were assessed with logistic regression analyses.RESULTS: Using the CII, the prevalence of cognitive impairment was 4.3% in the Tracking and 5.0% in the Comprehensive cohorts. The CII demonstrated strong convergent and discriminant validity. CONCLUSIONS: The algorithm for the CII is a feasible method to identify participants who demonstrate cognitive impairment on a battery of tests. These methods can be applied in other epidemiological studies that use neuropsychological batteries.

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Section: Introductionmentioning

confidence: 99%

Cognitive Impairment Indicator for the Neuropsychological Test Batteries in the Canadian Longitudinal Study on Aging: Definition and Evidence for Validity

O’Connell

Kadlec

Griffith

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Although cognitive difficulties are not considered “core” symptoms of migraine, a low percentage of patients may experience transient and premonitory cognitive symptoms, such as speech or language impairment, as part of typical aura, but also color and face recognition difficulties, and memory abnormalities ( 3 , 15 ). Transient neuropsychological problems, such as poor ability to concentrate and feeling of distraction, incapacity to think clearly and to deal with multiple tasks, are often described in the ictal phase of the migraine attacks and may contribute to the attack-related disability ( 16 – 18 ). These reversible neuropsychological disturbances have been attributed to the widespread and complex brain modifications and dysfunction underlying the development of the migraine attacks ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

“…Transient neuropsychological problems, such as poor ability to concentrate and feeling of distraction, incapacity to think clearly and to deal with multiple tasks, are often described in the ictal phase of the migraine attacks and may contribute to the attack-related disability ( 16 – 18 ). These reversible neuropsychological disturbances have been attributed to the widespread and complex brain modifications and dysfunction underlying the development of the migraine attacks ( 16 ). Since transient cognitive symptoms may also persist after the resolution of pain ( 16 , 19 ), they cannot be merely explained by pain ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

“…These reversible neuropsychological disturbances have been attributed to the widespread and complex brain modifications and dysfunction underlying the development of the migraine attacks ( 16 ). Since transient cognitive symptoms may also persist after the resolution of pain ( 16 , 19 ), they cannot be merely explained by pain ( 16 ). Electrophysiological and functional alterations in cortical functioning during the free pain interval have been reported in both children and adults ( 20 – 23 ), suggesting the presence of interictal cognitive dysfunctions in patients suffering from migraine.…”

Section: Introductionmentioning

confidence: 99%

“…Neuropsychological studies in adults found impaired cognitive functions, such as attention, processing speed (reaction time), executive functioning, verbal and visual memory, during the interictal phase of migraine ( 16 , 35 , 36 ). With regard to children and adolescents, data concerning the cognitive functioning in the free pain interval are under-investigated and results are far from conclusive ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Interictal Cognitive Performance in Children and Adolescents With Primary Headache: A Narrative Review

et al. 2022

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Primary headache is a very common and disabling disease. The burden of pain and recurrent attacks may lead to a poor quality of life, anxiety and depression. An increased risk of low functioning and curricular performances in young patients with primary headache has been described. The mechanisms underlying the relationship between migraine and poor school achievement may be various and could be a reflection of weak cognitive skills. Data concerning the cognitive functioning in the free pain interval in pediatric age are under-investigated and results are far from conclusive. The present review article suggests that, though considered a benign disease, pediatric migraine may be associated to altered neuropsychological functioning in the interictal phase. Although children and adolescents with migraine generally have a normal intelligence, they may show a not homogeneous cognitive profile, characterized by possible difficulties in verbal skills, in particular comprehension abilities. Pediatric primary headache may present altered neuropsychological functioning involving attentional resources, processing speed and memory, particularly verbal memory. Given the impact that this disease can have on school performance and the tendency to persist from childhood to adulthood, a cognitive screening in young patients affected by primary headache is pivotal. Additional neuropsychological research using more homogenous methods is needed.

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