Isolated involvement of external capsules and claustrum in status epilepticus

Silva, Rodrigo Alencar e; Sousa, Thadeu Alexandre Paulino De

doi:10.1590/0004-282x20190040

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Claustrum disfunction has been associated with several neurological and clinical pathologies, including Wilson’s disease [ 78 ], epilepsy [ 79 ], Lewy body dementia [ 3 , 80 ], schizophrenia [ 46 ], sleep disturbance, depressive symptoms, psychomotor retardation, anhedonia [ 72 ]. Some findings show that delusions and hallucinations in schizophrenia can be explained by the claustrum’s involvement in consciousness formation [ 81 ].…”

Section: Resultsmentioning

confidence: 99%

The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology

et al. 2021

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Introduction The claustrum is a structure involved in formation of several cortical and subcortical neural microcircuits which may be involved in such functions as conscious sensations and rewarding behavior. The claustrum is regarded as a multi-modal information processing network. Pathology of the claustrum is seen in certain neurological disorders. To date, there are not enough comprehensive studies that contain accurate information regarding involvement of the claustrum in development of neurological disorders. Objective Our review aims to provide an update on claustrum anatomy, ontogenesis, cytoarchitecture, neural networks and their functional relation to the incidence of neurological diseases. Materials and methods A literature review was conducted using the Google Scholar, PubMed, NCBI MedLine, and eLibrary databases. Results Despite new methods that have made it possible to study the claustrum at the molecular, genetic and epigenetic levels, its functions and connectivity are still poorly understood. The anatomical location, relatively uniform cytoarchitecture, and vast network of connections suggest a divergent role of the claustrum in integration and processing of input information and formation of coherent perceptions. Several studies have shown changes in the appearance, structure and volume of the claustrum in neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), autism, schizophrenia, and depressive disorders. Taking into account the structure, ontogenesis, and functions of the claustrum, this literature review offers insight into understanding the crucial role of this structure in brain function and behavior.

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Section: Resultsmentioning

confidence: 99%

The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology

et al. 2021

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Bilateral external capsule hyperintensities post-status epilepticus: case report and literature review

Aldaher,

Mohamohd,

Alshehhi

et al. 2024

Acta Neurol Belg

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Is there room in epilepsy for the claustrum?

Watson,

Meletti,

Mahavadi

et al. 2024

Front. Syst. Biol.

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The function of the claustrum and its role in neurological disorders remains a subject of interest in the field of neurology. Given the claustrum’s susceptibility to seizure-induced damage, there is speculation that it could serve as a node in a dysfunctional epileptic network. This perspective article aims to address a pivotal question: Does the claustrum play a role in epilepsy? Building upon existing literature, we propose the following hypotheses for the involvement of the claustrum in epilepsy: (1) Bilateral T2/FLAIR magnetic resonance imaging (MRI) hyperintensity of the claustrum after status epilepticus represents a radiological phenomenon that signifies inflammation-related epileptogenesis; (2) The ventral claustrum is synonymous with a brain area known as ‘area tempestas,’ an established epileptogenic center; (3) The ventral subsector of the claustrum facilitates seizure generalization/propagation through its connections with limbic and motor-related brain structures; (4) Disruption of claustrum connections during seizures might contribute to the loss of consciousness observed in impaired awareness seizures; (5) Targeting the claustrum therapeutically could be advantageous in seizures that arise from limbic foci. Together, evidence from both clinical case reports and animal studies identify a significant role for the ventral claustrum in the generation, propagation, and intractable nature of seizures in a subset of epilepsy syndromes.

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Isolated involvement of external capsules and claustrum in status epilepticus

Cited by 3 publications

References 2 publications

The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology

The mystery of claustral neural circuits and recent updates on its role in neurodegenerative pathology

Bilateral external capsule hyperintensities post-status epilepticus: case report and literature review

Is there room in epilepsy for the claustrum?

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