Protective effect of extract of the Camellia japonica L. on cerebral ischemia-reperfusion injury in rats

Lu, Weizhuo; Xv, Ling; Wen, Jiyue

doi:10.1590/0004-282x20180146

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…74 Ethanolic extracts obtained from fresh flowers of C. japonica at doses of 40, 80 mg/kg significantly reduced serum MDA levels in rats. 75 The C. japonica bee pollen ethyl acetate extract (including gallic acid, p-hydroxybenzoic acid, ferulic acid, ellagic acid, quercetin and kaempferol) at doses of 2 and 4 g/kg showed a significant decrease in liver MDA contents in mice liver. 76 Biflavonoids and kaempferol from shells of C. oleifera at a dose of 200 mg/kg reduced levels in blood serum of mice in each group by nearly 50%.…”

Section: Discussionmentioning

confidence: 96%

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

Chau

Hương

et al. 2023

Pharmacognosy Magazine

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Background Leaves, flowers and young shoots of yellow Camellia species are often used as a substitute for green tea in Vietnam. Yellow Camellia species contain high levels of polyphenol compounds, and have shown activities such as antioxidant, anticancer, and cytotoxic. Objectives We qualitatively screened phytochemicals, quantified total polyphenols of 70% ethanol (EtOH) extracts of leaves, young shoots, and flowers of Camellia vuquangensis and Camellia hatinhensis in Ha Tinh Province, Vietnam. Furthermore, these extracts have been evaluated for lipid peroxidation inhibitory activities at the in vivo level in the BALB/c mouse model, and in vitro cytotoxic activities. Materials and Methods Chemical methods and thin-layer chromatographic (TLC) analysis were used for the qualitative screening of phytochemicals. High-performance liquid chromatography (HPLC) was used to determine total polyphenols. Cell survival was determined through optical density (OD) measured when the protein composition of the cells was stained with sulforhodamine B (SRB). Inhibition of lipid peroxidation was evaluated by determining the content of malondialdehyde (MDA), which is a product of membrane lipid peroxidation. Results The total polyphenol contents of all parts of the two species were comparable to that of green tea with values between 319.3 and 342.6 mg gallic acid equivalents (GAE/g) dry weight. Extracts of leaves, flowers of C. vuquangensis and C. hatinhensis showed strong lipid peroxidation inhibitory activities (IC50: 7.92–17.45 µg/mL) and moderate cytotoxic activities against cell lines HepG2, A549, MCF7, SK-Mel-2, HT-29, and AGS (IC50: 34.73–80.58 µg/mL). Conclusion These two tea species may be considered as herbal teas with various health benefits.

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Section: Discussionmentioning

confidence: 96%

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

Chau

Hương

et al. 2023

Pharmacognosy Magazine

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“…It is the most important ornamental species in its taxonomic group (Vela et al, 2013) not only for the aesthetic beauty of its flowers but also for its role in medical and cosmetic fields: in fact, recent investigations showed its value in terms of bioactive compound content and antioxidant profile (Kim et al, 2019;Lu et al, 2019;Páscoa et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

A complex virome including two distinct emaraviruses associated with virus-like symptoms in Camellia japonica

et al. 2020

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Camellia japonica plants manifesting a complex and variable spectrum of viral symptoms like chlorotic ringspots, necrotic rings, yellowing with necrotic rings, yellow mottle, leaves and petals deformations, flower color-breaking were studied since 1940 essentially through electron microscopic analyses; however, a strong correlation between symptoms and one or more well characterized viruses was never verified. In this work samples collected from symptomatic plants were analyzed by NGS technique and a complex virome composed by viruses members of the Betaflexiviridae and Fimoviridae families was identified. In particular, the genomic fragments typical of the emaravirus group were organized in the genomes of two new emaraviruses species, tentatively named Camellia japonica associated emaravirus 1 and 2. They are the first emaraviruses described in camellia plants and were always found solely in symptomatic plants. On the contrary, in both symptomatic and asymptomatic plants, we detected five betaflexiviruses isolates that, based on aa identitiy

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“…However, almost all the trials have been unsuccessful [5][6][7]. The resulting pessimism has turned researchers' attention towards the development of a "preventive agent" in an effort to minimize the neuronal damage during a future fCI insult [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property

Lee

Jeong

et al. 2019

Anat Cell Biol

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The leaf extract of Platycarya strobilacea (PSL) has long been recognized as possessing various health-promoting activities. However, information on its possible protective effects against ischemic stroke is currently lacking. Here, using a mouse model of focal cerebral ischemia (fCI), we studied the protective potential of an oral supplement of PSL. Mice were randomly divided into four groups: SO, a group subjected to a sham-operation; VEH, pretreated with distilled water and subjected to middle cerebral artery occlusion and reperfusion (MCAO/R); PSL-L and PSL-H, pretreated with low (20 mg/ kg) and high (100 mg/kg) doses of PSL, respectively, and subjected to the MCAO/R procedure. PSL was administered via an oral route daily for 8 days prior to surgery. We then measured the infarct volumes and sensorimotor deficits and studied the underlying antioxidant mechanisms by quantifying apoptosis, reactive oxygen species (ROS) generation, oxidative damages, and antioxidant enzymes in the ischemic cortex. The results showed a marked attenuation in infarct volume and sensorimotor deficits in both the PSL-L and PSL-H groups when compared with VEH. The terminal deoxynucleotidyl transferase dUTP nick end labeling and the immunohistochemical detection of the cleaved caspase-3 revealed that PSL could reduce cellular apoptosis in the ischemic lesion in a dose-dependent manner. The dihydroethidium-fluorescence, 4-hydroxynonenal, and 8-hydroxyl-2'-deoxyguanosine immunoreactivities in the ischemic lesion were markedly attenuated in the PSL-L group compared with the VEH group, indicating that PSL could attenuate ROS generation and the associated oxidative damage in the ischemic cortex. Finally, western blot results indicated that PSL can upregulate levels of heme oxygenase-1 (HO-1), an antioxidant enzyme, in the lesion area. Together, these results suggest that PSL can exert protective effects against fCI, and the mechanism may involve HO-1 upregulation.

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Protective effect of extract of the Camellia japonica L. on cerebral ischemia-reperfusion injury in rats

Cited by 7 publications

References 23 publications

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

A complex virome including two distinct emaraviruses associated with virus-like symptoms in Camellia japonica

Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property

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