Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Haddadi, Hossein; Rajaei, Ziba; Alaei, Hojjatallah; Shahidani, Somayeh

doi:10.1590/0004-282x20170193

Cited by 39 publications

(17 citation statements)

References 33 publications

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“…Our results are in line with previous studies where chronic treatment with carvacrol, a phenolic monoterpene abundantly presented in the essential oil of the Lamiaceae family, improved memory deficits in the 6-hydroxydopamine Parkinson's disease (PD) rat model [39]. Supporting evidence suggested many pharmacological effects of the carvacrol, including antibacterial, antifungal, antioxidant, antinociceptive, anti-inflammatory, antiapoptosis, and anticancer activi-ties [40].…”

Section: Effects Of (-)-Cis-carveol On Spatial Memory Impairment In Ysupporting

confidence: 91%

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Hrițcu

Boiangiu

Morais

et al. 2020

BioMed Research International

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Alzheimer’s disease (AD) could be considered a multifactorial neurodegenerative disorder characterized by the accumulation of the β-amyloid-peptide (Aβ) within the brain leading to cognitive deficits, oxidative stress, and neuroinflammation. The present work was carried out to investigate the neuroprotective effect of (-)-cis-carveol (1% and 3%, for 21 days) against the β-amyloid-peptide 1-42- (Aβ1-42-) induced AD. Twenty-five rats were divided into five groups (n=5/group): the first group—control (sham-operated); the second group—Aβ1-42 (1 mM) that received donepezil treatment (5 mg/kg, as the positive reference drug in the Y-maze and the radial arm maze tests); the third group—Aβ1-42 (1 mM); the fourth and fifth groups—Aβ1-42 (1 mM) that received (-)-cis-carveol treatment groups (1% and 3%). The results of this study demonstrated that (-)-cis-carveol improved Aβ1-42-induced memory deficits examined by using Y-maze and radial arm maze in vivo tests. Also, the biochemical analyses of the hippocampus homogenates showed that (-)-cis-carveol reduced hippocampal oxidative stress caused by Aβ1-42. Our results suggested that the use of (-)-cis-carveol may be suitable for decreasing AD-related symptoms.

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Section: Effects Of (-)-Cis-carveol On Spatial Memory Impairment In Ysupporting

confidence: 91%

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Hrițcu

Boiangiu

Morais

et al. 2020

BioMed Research International

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“…In line with this, it has been reported that carvacrol (25, 50, 100 mg/kg) attenuated diabetes-associated cognitive deficits by decreasing malondialdehyde levels and increasing superoxide dismutase activity and reduced glutathione levels in the hippocampus and cortex of diabetic rats 21 . In a recent study, it was reported that chronic treatment with carvacrol improved passive avoidance memory in a rat model of PD; however, the mechanism of action was not examined 25 . Biochemical data in the present study did not confirm antioxidant activity of carvacrol in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

“…In the test session, each rat was again placed into the light compartment. The step-through latency of entering the dark compartment was measured as a positive index of memory performance, with a 300 second cut-off time 25 .…”

Section: Passive Avoidance Memorymentioning

confidence: 99%

Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease

Hamzehloei

Rezvani

Rajaei

2019

Arq. Neuro-Psiquiatr.

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The present study was undertaken to investigate the effects of carvacrol and treadmill exercise on memory deficit, rotational behavior and oxidative stress biomarkers in a 6-OHDA-lesioned rat model of Parkinson’s disease. Wistar rats were treated with carvacrol at a dose of 25 mg/kg and/or ran on a treadmill for a week. Then, 6-OHDA was microinjected into the medial forebrain bundle and treatments continued for six more weeks. Aversive memory, rotational behavior and oxidative stress biomarkers were assessed at the end of week six. The 6-OHDA-lesioned group showed a significant increase in rotational behavior and a decrease in step-through latency in the passive avoidance test compared with the sham group. These behaviors were accompanied by increased lipid peroxidation levels and decreased total thiol concentration in the striatum and/or hippocampus of the hemiparkinsonian rats. Moreover, treatment with carvacrol and exercise reduced rotational behavior and improved aversive memory deficit, which was accompanied by decreased lipid peroxidation levels and increased total thiol concentration in the striatum and/or hippocampus. In conclusion, treatment with carvacrol and treadmill exercise ameliorated motor and memory deficits by modulating oxidative stress in the striatum and hippocampus of hemiparkinsonian rats. Therefore, the combination of carvacrol and treadmill exercise could be an effective therapeutic tool for treatment of neurobehavioral deficits in Parkinson’s disease patients.

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“…The retention transfer latency, which was defined as the time taken for the mice to enter the dark chamber with all its four legs from the light chamber after the electric shock, was recorded [25]. If the mice did not enter the dark chamber within the cutoff period of 180 s, it was assumed that the mice remembered the previous electric shock experience [22,26].…”

Section: Passive Avoidance Testmentioning

confidence: 99%

Long-term Administration of Lovastatin and Rivastigmine: An In Vivo Evaluation on Cognitive Functions and Brain Acetylcholinesterase Activity

Badruddeen

Akhtar

Arif

et al. 2020

INNOSC Theranostics and Pharmacological Sciences

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Background. There is not much evidence illustrating that statins could be responsible for memory loss or dementia, although increased exposure to statins has been reported to cause cognitive side effects. The present study investigated the effect of lovastatin in combination with rivastigmine on cognitive function as well as brain acetylcholinesterase (AChE) activity in normal mice. Methods. The mice were categorized into four groups, and they were treated with normal saline, lovastatin, rivastigmine, and the combination of lovastatin and rivastigmine, respectively, by oral administration for 60 days. The treatment effect on cognitive functions was assessed by behavioral tests, namely, the passive avoidance test and spontaneous alternation test, as well as the measurement of brain AChE activity by Ellman’s method. Results. In this study, a significant reduction (P < 0.01) of brain AChE activity and positive effects (P < 0.01) on cognitive functions was observed in mice treated with the combination of lovastatin and rivastigmine as compared to rivastigmine alone. However, no significant differences (P < 0.05) were observed on brain AChE activity as well as cognitive functions in mice treated with lovastatin when compared with those treated with normal saline. Conclusion. This study suggested that lovastatin did not contribute to any improvements in cognitive functions and brain AChE activity, but it potentiated the effect of rivastigmine.

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Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Cited by 39 publications

References 33 publications

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease

Long-term Administration of Lovastatin and Rivastigmine: An In Vivo Evaluation on Cognitive Functions and Brain Acetylcholinesterase Activity

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