Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

Baghcheghi, Yousef; Hosseini, Mahmoud; Beheshti, Farimah; Salmani, Hossein; Anaeigoudari, Akbar

doi:10.1590/0004-282x20170182

Cited by 46 publications

(21 citation statements)

References 28 publications

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“…However, TQ administration improved the disturbed thyroid function. In the same context, Baghcheghi et al reported that thymoquinone significantly increased the T4 level in PTU-induced juvenile hypothyroid rats [25]. In addition, it was reported that antioxidant agents, such as vitamin C, improved the disturbed serum T4, T3, and TSH levels in patients with hypothyroidism [26].…”

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confidence: 95%

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Ayuob

Balgoon

El-Mansy

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. The association between hypothyroidism and renal diseases has been described in many studies. Nigella Sativa was among the recently reported natural product that has the potential to prevent renal tissue damage and fibrosis. The aim of this study was to evaluate the possible protective effect of thymoquinone on the structure of the renal cortex of hypothyroid rats and explore the mechanism behind it. Methods. An experimental model of hypothyroidism was induced in adult male Wistar rats by administration of propylthiouracil (6 mg/kg/body weight). One hypothyroid group was treated with thymoquinone at the dose of 50 mg/kg/body weight and compared to the untreated group. Thyroid function and oxidant/antioxidant status were assessed in the serum. Catalase gene expression was assessed using the real-time polymerase chain reaction. The kidney was assessed both histologically and immunohistochemically. Results. Administration of propylthiouracil resulted in a significant decrease in the serum levels of nitric oxide, reduced glutathione, and superoxide dismutase activity while the level of malondialdehyde significantly (p<0.001) increased. Administration of thymoquinone alleviated this effect on the thyroid hormones and significantly increased the serum levels of antioxidants. Thymoquinone significantly (p<0.001) upregulated catalase transcription by about 24-fold and could block the hypothyroidism-induced glomerular and tubular injury. Conclusion. Thymoquinone may have a potential protective effect against hypothyroidism-induced renal injury acting through the attenuation of the oxidative stress and upregulation of renal catalase gene expression.

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confidence: 95%

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Ayuob

Balgoon

El-Mansy

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…SCE has a significant antagonistic effect on the memory reproduction disorder caused by a low concentration of ethanol with central inhibition, suggesting that SCE may improve the cytotoxic response caused by ethanol, and SCE can repair the cell damage caused by the phospholipid and fatty acid metabolism disorder, as well as increase the oxidative metabolites induced by the ethanol intake. 19 SCE can also improve the short-term spatial memory ability of aging model mice and improve the anti-fatigue ability of the body, which may be related to the regulation of SCE on the expression of related proteins to improve the antioxidant ability of the body. Oxidative stress is an important factor in the pathogenesis of Alzheimer's disease (AD), and antioxidant therapy can improve the symptoms of AD by reducing oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of Schisandra chinensis Extract on the Learning and Memory Ability of Mice With Learning and Memory Disorders

Lili

Tang

Chen

et al. 2020

Natural Product Communications

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The effect of Schisandra chinensis extract (SCE) on the learning and memory ability of mice with learning and memory disorders was investigated. After mice were given SCE prophylactically, different methods were used to establish mouse learning and memory disorders, and the radial maze test was used for the observation of SCE on the learning and memory ability of mice with learning and memory disorders. A mouse aging model was established by subcutaneously injecting d-galactose. The antiaging, antifatigue, and antioxidant effects of SCE were evaluated by weight change, the loaded swimming test, and changes in total antioxidant capacity and superoxide dismutase (SOD) levels in the serum and brain of mice. The result showed that SCE could significantly improve the learning and memory behavior of mice with learning and memory disorders induced by scopolamine, chloramphenicol, and 40% ethanol, respectively, maintain normal weight gain, prolong the loaded swimming time, improve the antioxidant capacity, and increase the activity of SOD in the serum and brain of aging mice. SCE can significantly improve the learning and memory ability of mice with learning and memory disorders, which may be related to its antioxidant effect.

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“…In accordance with that, it was previously reported that TQ significantly increased the T4 level in PTU-induced juvenile hypothyroid rats. 32 …”

Section: Discussionmentioning

confidence: 99%

Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic β-Catenin in Hypothyroid Rats

Faddladdeen

Ali

Bahshwan

et al. 2021

DMSO

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Background Altered status of thyroid hormones, which have a key role in regulating metabolism, was reported to affect glucose homeostasis and insulin secretion. Objective This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting β-catenin expression. Materials and Methods PTU (6 mg/kg/body weight) was used to induce hypothyroidism in Wistar rats. Four groups of rats (n=6 each) were utilized in this study. Untreated hypothyroid and TQ-treated hypothyroid groups (50 mg/kg/body weight for 4 weeks) were included. Thyroid functions, antioxidant profile and pancreatic β-catenin and IL-10 mRNA were measured. Histopathological and immunohistochemical assessment of the pancreas was performed. Results PTU administration induced a hypothyroid status that was associated with a marked disturbed oxidant/antioxidant status and a significant hyperglycemia (p<0:001), hypoinsulinemia (p=0.01) and decreased HOMA-β-cell (p<0.001). Islet cells of hypothyroid pancreas showed many degenerative changes with increased apoptosis, reduced insulin β-catenin immunoexpression. Administration of TQ alleviated these effects on the thyroid function, antioxidants, structure of pancreatic islet cells. Up-regulation of β-catenin, IL-10 and CAT gene expression in pancreatic islets after treatment with TQ supported its antioxidant and preserving β-cell function and viability mechanistic action. Conclusion TQ alleviated PTU-induced hypothyroidism changes in insulin homeostasis and pancreatic β cells mostly through its antioxidant effect as well as up-regulation of pancreatic β-catenin expression.

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Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

Cited by 46 publications

References 28 publications

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats

Effects of Schisandra chinensis Extract on the Learning and Memory Ability of Mice With Learning and Memory Disorders

Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic β-Catenin in Hypothyroid Rats

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