Incidental detection of probable meningioma in brain scintigraphy using 99mTc-TRODAT-1

Technetium-99m labeled tropane derivative: Uptake in a pituitary macroadenoma

“…[1234] The extrastriatal uptake of TRODAT has been reported in PM, primary brain tumors, brain metastases, meningioma, osteoid tumor of clivus, intracranial tuberculoma, and subdural hematoma. [5678910111213] The possibility of extrastriatal accumulation of TRODAT interfering with image interpretation as in our case should be kept in mind, while planning TRODAT SPECT and alternative modalities like FDOPA PET with superior image quality and resolution should be resorted to at the outset. F-18 FDOPA is an analog of DOPA and serves as substrate for aromatic amino acid decarboxylase that converts dopa to dopamine.…”

Tumor-Induced Parkinsonism Due to a Large Meningioma Diagnosed by 99mTc-TRODAT-1 SPECT/CT

“…The most common tumor is meningioma, especially when located in the sphenoidal ridge or frontoparietal area 5 . The findings of DAT scintigraphy in tumor-induced parkinsonism are different among a few previous reports with a spectrum of absent or decreased uptake in the involved striatum 6–8 to cases with normal DAT uptake 9,10 . These differences could be explained by the involvement of presynaptic or postsynaptic pathways.…”