Early reperfusion therapy in acute ischemic stroke after recent myocardial infarction

Kuster, Gustavo W.; Baruzzi, Antônio Cláudio do Amaral; Pacheco, Evelyn de Paula; Domingues, Renan Barros; Pieruccetti, Marco Antonio; Giacon, Luciano; Garcia, José Carlos; Furlan, Valter; Massaro, Ayrton Roberto

doi:10.1590/0004-282x20160099

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…The incidence rate of IS is high in the elderly, and the disease severely affects the prognosis of MI patients ( 3 ). MI patients complicated with IS have a significantly higher mortality rate than patients with MI alone ( 4 , 5 ), which has attracted extensive attention in the clinic. Studies have shown that there are often abnormal ECG changes of patients with acute IS, and ECG changes of these patients are very sensitive with a very low specificity, suggesting that ECGs are insufficient to be used as a diagnostic criterion for IS ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Influence of interleukin-1β gene polymorphism on the risk of myocardial infarction complicated with ischemic stroke

Chen

Wang

et al. 2018

Exp Ther Med

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This study investigated the correlation between interleukin (IL)-1β-511C/T gene polymorphism and myocardial infarction (MI) complicated with ischemic stroke (IS). A total of 251 MI patients complicated with IS (observation group) and 200 healthy people (control group) were selected for the case-control study. IL-1β-511C/T gene polymorphism was detected via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype distribution and allele frequency were compared between the two groups, and the correlation between gene polymorphism and MI complicated with IS, was analyzed after traditional risk factors were adjusted by using logistic regression method. The frequencies of CT and TT genotypes in the observation group were higher than those in the control group (P<0.05). The frequency of T allele in the observation group was significantly higher than that in the control group (P<0.05), but the frequency of C allele was obviously lower than that in the control group (P<0.05). According to results of logistic regression analysis, arrhythmia and high-density lipoprotein cholesterol (HDL-C) were associated with MI complicated with IS. In patients with arrhythmia, the risk of disease in carriers with IL-1β-511T gene was 1.7–1.8 times that in non-carriers [odds ratio (OR) = 1.742 and 1.839, P<0.05]. In patients with abnormal HDL-C, the risk of disease in carriers with IL-1β-511T gene was 2.0–2.2 times that in non-carriers (OR = 2.011 and 2.249, P<0.05). Besides, the risk of MI complicated with IS in carriers with CC genotype had no significant difference in patients with arrhythmia and abnormal HDL-C (P>0.05). IL-1β-511C/T gene polymorphism may be related to the risk of MI complicated with IS.

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Section: Introductionmentioning

confidence: 99%

Influence of interleukin-1β gene polymorphism on the risk of myocardial infarction complicated with ischemic stroke

Chen

Wang

et al. 2018

Exp Ther Med

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“…The stent retriever is also an alternative when thrombolytics are contraindicated, such as after a myocardial infarction within the previous three months 22 . The stent retriever has the potential risk of arterial dissection, muscular spasm and endothelium lesion and this risk increases with the number of passes over the artery.…”

Section: Discussionmentioning

confidence: 99%

Rescue therapy with stent retrievers for thromboembolism during endovascular treatment of intracranial aneurysms

Demartini

Gatto

Koppe

et al. 2018

Arq. Neuro-Psiquiatr.

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Thromboembolism is the most frequent complication in endovascular treatment of intracranial aneurysms, causing disability and death. As stent retrievers have achieved high rates of arterial recanalization in the management of ischemic stroke, these devices were tested as rescue therapy of thromboembolism during aneurysm embolization. We retrospectively analyzed 10 consecutive patients with transprocedural arterial occlusion, treated with mechanical thrombectomy at a single center. Good angiographic recanalization was achieved in eight cases, mTICI 3, 2b and 2a in five, three and two patients, respectively, without additional complications or any deaths. Five patients showed complete recovery (mRS 0) and all patients showed improvement of disability (average mRS 1.1) over a mean follow-up period of 31 months. Eight patients had good clinical recovery, while two remained with deficits (mRS 3 and 4). The study found that the stent retriever is a valuable, rapid and effective tool for restoring blood flow, improving the safety of endovascular treatment.

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“…The Garcia scale uses 6 tests to assess the asymmetry of the animal’s movements and reactions in points (from 1, pronounced impairment, to 3, no impairment), which are also then summarized. The minimum neurological result is 3 points (maximum impairment), and the maximum is 18 points (no impairment) [ 55 ].…”

Section: Methodsmentioning

confidence: 99%

Overexpression of Brain- and Glial Cell Line-Derived Neurotrophic Factors Is Neuroprotective in an Animal Model of Acute Hypobaric Hypoxia

Gavrish

Urazov

Mishchenko

et al. 2022

IJMS

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Currently, the role of the neurotrophic factors BDNF and GDNF in maintaining the brain’s resistance to the damaging effects of hypoxia and functional recovery of neural networks after exposure to damaging factors are actively studied. The assessment of the effect of an increase in the level of these neurotrophic factors in brain tissues using genetic engineering methods on the resistance of laboratory animals to hypoxia may pave the way for the future clinical use of neurotrophic factors BDNF and GDNF in the treatment of hypoxic damage. This study aimed to evaluate the antihypoxic and neuroprotective properties of BDNF and GDNF expression level increase using adeno-associated viral vectors in modeling hypoxia in vivo. To achieve overexpression of neurotrophic factors in the central nervous system’s cells, viral constructs were injected into the brain ventricles of newborn male C57Bl6 (P0) mice. Acute hypobaric hypoxia was modeled on the 30th day after the injection of viral vectors. Survival, cognitive, and mnestic functions in the late post-hypoxic period were tested. Evaluation of growth and weight characteristics and the neurological status of animals showed that the overexpression of neurotrophic factors does not affect the development of mice. It was found that the use of adeno-associated viral vectors increased the survival rate of male mice under hypoxic conditions. The present study indicates that the neurotrophic factors’ overexpression, induced by the specially developed viral constructs carrying the BDNF and GDNF genes, is a prospective neuroprotection method, increasing the survival rate of animals after hypoxic injury.

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Early reperfusion therapy in acute ischemic stroke after recent myocardial infarction

Cited by 3 publications

References 5 publications

Influence of interleukin-1β gene polymorphism on the risk of myocardial infarction complicated with ischemic stroke

Influence of interleukin-1β gene polymorphism on the risk of myocardial infarction complicated with ischemic stroke

Rescue therapy with stent retrievers for thromboembolism during endovascular treatment of intracranial aneurysms

Overexpression of Brain- and Glial Cell Line-Derived Neurotrophic Factors Is Neuroprotective in an Animal Model of Acute Hypobaric Hypoxia

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