Cognitive deficits in chronic pain patients, in a brief screening test, are independent of comorbidities and medication use

Ferreira, Karen dos Santos; Oliver, Gabriela Z; Thomaz, Débora Carinhato; Teixeira, Caroliny Trevisan; Foss, Maria Paula

doi:10.1590/0004-282x20160071

Cited by 42 publications

(29 citation statements)

References 20 publications

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“…A previous study 30 reported that the patients with chronic pain had a poorer performance in the MoCA instrument (total score), Verbal Fluency Test, Clock Drawing Test and Stroop Test. The group with chronic pain also had a higher frequency of depressive disorder, generalized anxiety disorder, non-repairing sleep and hypothyroidism.…”

Section: Discussionmentioning

confidence: 88%

Chronic migraine patients show cognitive impairment in an extended neuropsychological assessment

Ferreira

Teixeira

Cáfaro

et al. 2018

Arq. Neuro-Psiquiatr.

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The objective of the present study was to assess the presence of cognitive deficits in patients with chronic migraine, and to assess the main factors that trigger cognitive disorders, such as comorbidities or the use of medications. Methods: Chronic migraine and control groups were interviewed in a case-control study. The frequency and intensity of the headache, medication used and associated comorbidities were determined. All patients were submitted to an extended neuropsychological assessment. Results: The chronic migraine group (n = 30) had a worse performance in the Montreal Cognitive Assessment Test (p = 0.00), Verbal Fluency (p = 0.00), Stroop (p = 0.00), Clock Drawing Test (p = 0.00), Digit Span (p = 0.00) and Matrix Reasoning (p = 0.01). After statistical adjustment by linear regression, migraine continued to be the only relevant factor in the poorer performance in the Montreal Cognitive Assessment, Verbal Fluency, Clock Drawing and Stroop tests. Conclusion: Patients with chronic migraine have cognitive deficits in multiple tasks, regardless of the presence of comorbidities or the use of medications.

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Section: Discussionmentioning

confidence: 88%

Chronic migraine patients show cognitive impairment in an extended neuropsychological assessment

Ferreira

Teixeira

Cáfaro

et al. 2018

Arq. Neuro-Psiquiatr.

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“…Since many functional regions are shared for pain processing and cognitive processing, patients with chronic pain often complain cognitive impairment and inattention. 51,52 Pain-related attention and emotion are closely associated with medial temporal cortex, which is considered to be linked with pain integration and pain perception. 33 Increased grey matter volume (GMV) in the middle temporal lobes was found in postherpetic neuralgia 53 and low-back pain altered several functional brain regions including middle temporal lobes, 54,55 and a similar result was reported in burning mouth syndrome patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Brain Functional Alternations of the Pain-related Emotional and Cognitive Regions in Patients with Chronic Shoulder Pain</p>

Li¹,

Yan²,

Wang³

et al. 2020

JPR

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Objective: Chronic shoulder pain (CSP) is a common health problem associated with shoulder dysfunction and persistent pain for many different reasons. However, the studies of pain-related functional brain regions in CSP have been poorly investigated. The main purpose of our study was to observe whether there are abnormal functional changes in brain regions in patients with CSP by using functional magnetic resonance imaging (fMRI). Patients and Methods:We compared the differences of brain regions between 37 patients with CSP and 24 healthy controls (HC) using regional homogeneity (ReHo) method. The patients with chronic shoulder pain and healthy controls were matched for age and gender. Brain regions which had abnormal ReHo values were defined as seed region of interests. The approach of seed-based functional connectivity (FC) was further performed to analyze the connectivity between the seeds and whole brain regions. The relationship between abnormal regions and current clinical pain was also evaluated. Results: Compared to healthy controls, the patients with CSP showed increased ReHo values in the left middle temporal gyrus and decreased ReHo values in right orbitofrontal cortex (OFC). The seed-based analyses demonstrated decreased connectivity between the right OFC and right rectus, superior frontal gyrus in patients with chronic shoulder pain. However, a correlation between ReHo values and clinical characteristics in CSP patients was not found. Conclusion: The observed results indicate that there are abnormal ReHo values in brain regions of patients with CSP, especially in the OFC and middle temporal gyrus. Our findings demonstrate that the experience of CSP patients may be mainly associated with cognitiveaffective pain processing, rather than nociception.

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“…Our adapted model of CCI altered the cognitive performance in the novel object recognition though not in the Y‐maze. Pain‐related cognitive deficits in humans (Ferreira, Oliver, Thomaz, Teixeira, & Foss, ) include not only impairments in working memory, but also a worse performance in a brief screening test like the MoCA, verbal fluency, clock drawing, and stroop tests. Impairments in attention and working memory have been both found in patients suffering chronic pain.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice

Medeiros

Freitas

Boccella

et al. 2019

J of Neuroscience Research

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The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury-based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of CCI by placing one single loose ligature around the sciatic nerve in mice for investigating the alterations in sensory, motor, affective, and cognitive behavior and in electrophysiological and biochemical properties in the prelimbic division (PrL) of the mPFC. Our adapted model of CCI induced mechanical allodynia, motor, and cognitive impairments and anxietyand depression-like behavior. In the PrL division of mPFC was observed an increase in GABA and a decrease in d-aspartate levels. Moreover an increase in the activity of neurons responding to mechanical stimulation with an excitation, mPFC (+), and a decrease in those responding with an inhibition, mPFC (−), was found. Altogether these findings demonstrate that a single ligature around the sciatic nerve was able to induce sensory, affective, cognitive, biochemical, and functional alterations already observed in other neuropathic pain models and it may be an appropriate and easily reproducible model for studying neuropathic pain mechanisms and treatments. K E Y W O R D Saffective and cognitive behavior, chronic constriction injury, GABA and d-aspartate levels, ongoing-and mechanically evoked neural activity, prelimbic division of the medial prefrontal cortex | 339 MEDEIROS Et al.

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Cognitive deficits in chronic pain patients, in a brief screening test, are independent of comorbidities and medication use

Cited by 42 publications

References 20 publications

Chronic migraine patients show cognitive impairment in an extended neuropsychological assessment

Chronic migraine patients show cognitive impairment in an extended neuropsychological assessment

<p>Brain Functional Alternations of the Pain-related Emotional and Cognitive Regions in Patients with Chronic Shoulder Pain</p>

Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice

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