Positive correlation between functional disability, excessive daytime sleepiness, and fatigue in relapsing-remitting multiple sclerosis

Braga, Daniela Paes de Almeida Ferreira; Prado, Gilmar Fernandes do; Bichueti, Denis Bernardi; Oliveira, Enedina Maria Lobato de

doi:10.1590/0004-282x20160069

Cited by 17 publications

(8 citation statements)

References 25 publications

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“…We also found that a higher level of fatigue occurs in patients with a longer duration of the disease. Many other studies reported similar conclusions [29,[38][39][40][41][42]. Interestingly, some studies confirmed correlation between fatigue and higher disability, but not with the disease duration [35].…”

Section: Discussionsupporting

confidence: 53%

Relationship between Fatigue and Physical Activity in a Polish Cohort of Multiple Sclerosis Patients

et al. 2020

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Background and objectives: Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS). It can be defined as a subjective lack of physical and mental energy. The aim of this study was to evaluate the frequency and severity of fatigue in patients with MS and its relationship with overall physical activity and disease-related disability. Materials and Methods: The study included 100 patients with a clinical relapsing-remitting form of MS. Patients with severe depression were excluded. Neurological impairment was rated using the Expanded Disability Status Scale (EDSS). Fatigue was assessed using the Modified Fatigue Impact Scale (MFIS) and the Fatigue Severity Scale (FSS), with FSS scores greater than 36 indicating patients with fatigue. Physical activity was evaluated with the International Physical Activity Questionnaire (IPAQ) and categorized on three levels: low, moderate, and high, using standard metabolic equivalents (MET). Results: The average FSS and MFIS scores were (mean ± SD) 31.3 ± 15.2 and 30.1 ± 17.0, respectively. The mean EDSS score was 2.5 ± 1.5. 42%. Patients were classified as fatigued based on FSS. Fatigued patients had higher mean EDSS scores than non-fatigued (3.0 ± 1.6 vs. 2.2 ± 1.4, respectively, p = 0.002). Low, moderate, and high levels of physical activity were reported in 35%, 20%, and 45% of patients, respectively. Higher scores of fatigue in FSS and MFIS were inversely correlated with the intensity of physical activity (r = −0.38, p < 0.001 and r = −0.33, p < 0.001, respectively). Conclusions: In patients with MS, fatigue is a common symptom. Patients with lower physical activity and greater MS-related disability have a higher severity of fatigue, which negatively affects cognitive, psychosocial, and physical functioning.

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Section: Discussionsupporting

confidence: 53%

Relationship between Fatigue and Physical Activity in a Polish Cohort of Multiple Sclerosis Patients

et al. 2020

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“…Our study showed an association between disability (EDSS and GNDS) and the frequency of fatigue in relapsing-remitting MS patients. Similar findings have been reported in MS patients in different stages of the disease (EDSS 2.5-7) 18,19,20 . Although the GNDS is considered a valid tool for the evaluation of MS patients, we did not find any study that had used this as a scale of disability assessment and its relationship with the frequency of fatigue in this population.…”

Section: Discussionsupporting

confidence: 89%

Disability as a determinant of fatigue in MS patients

Taveira

Braz

Comini-Frota

et al. 2019

Arq. Neuro-Psiquiatr.

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Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p < 0.05). Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.

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“…Mental illnesses, medication use, and substance abuse or head injury must be also considered and excluded (American Academy of Sleep Medicine, 2014). EDS must not be better explained by internal, autoimmune (Braga et al, 2016) and neurological disorders such as neurodegenerative diseases (Arnulf, 2005;Moreno-Lopez et al, 2011) or inflammatory diseases, particularly neuroinfections (Pardasani et al, 2008;Krbkova et al, 2015).…”

Section: )mentioning

confidence: 99%

Idiopathic Hypersomnia and Depression, the Challenge for Clinicians and Researchers

Galušková

Šonka

2021

Prague Med. Rep.

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Positive correlation between functional disability, excessive daytime sleepiness, and fatigue in relapsing-remitting multiple sclerosis

Cited by 17 publications

References 25 publications

Relationship between Fatigue and Physical Activity in a Polish Cohort of Multiple Sclerosis Patients

Relationship between Fatigue and Physical Activity in a Polish Cohort of Multiple Sclerosis Patients

Disability as a determinant of fatigue in MS patients

Idiopathic Hypersomnia and Depression, the Challenge for Clinicians and Researchers

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