Chronic stage of Marchiafava-Bignami disease

Abstract

Marchiafava-Bignami disease, first described in 1903, is a rare condition characterized by demyelination of the corpus callosum seen in patients with chronic alcoholism or nutritional susceptibility. Magnetic resonance imaging (MRI) is currently the most sensitive diagnostic tool (Figure). A 24-year-old man, with a background of high level of alcohol abuse since he was 12, presented since last year behavioral and psychotic clinical manifestations characterized by elaborated visual and auditory delusions.

Reversible splenial lesion syndrome associated with lobar pneumonia

“…[56] MBD is a rare disease in patients with chronic alcoholism or nutritional susceptibility and is characterized by symmetric demyelination and necrosis of the corpus callosum which was first described in 1903. [57] The lesions in cranial MRI of MBD are not restricted to the corpus callosum, but may also occur in extracallosal white matter and cortical regions. [58] During the acute phase, the corpus callosum appears hypointense on T1WI, hyperintensity on T2WI (Fig.…”

Leucodistrofias e leucoencefalopatias genéticas em adultos: caracterização clínica, molecular e de neuroimagem

“…Por outro lado, a síndrome de Labrune tipicamente apresenta calcificações grosseiras e cistos exuberantes (Labrune et al, 1996). A história de uso de tabaco e bebidas alcoólicas poderia também induzir ao diagnóstico equivocado de síndrome de Marchiafava-Bignami, embora esta tenha um padrão de acometimento de substância branca diferente, com predomínio parietooccipital e lesão de corpo caloso (Lucato et al, 2015). Conforme comentamos na revisão de literatura da presente tese, a presença de tremor palatal poderia sugerir o diagnóstico, mas sua ausência não exclui a possibilidade de doença de Alexander, como comprova o caso da nossa paciente.…”