Neuroimaging features of progressive ataxia and palatal tremor

Pedroso, José Luiz; Pinto, Wladimir Bocca Vieira de Rezende; Souza, Paulo Victor Sgobbi de; Rivero, René Leandro Magalhães; Barsottini, Orlando Graziani Póvoas

doi:10.1590/0004-282x20150062

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…With the lack of other seminal findings on extensive aetiological work-up, the relatively isolated clinical PAPT syndrome, the disease course, and the cerebral imaging in this patient would be consistent with case reports of patients with presumed idiopathic PAPT [6,[9][10][11][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Patientsupporting

confidence: 83%

Four New Cases of Progressive Ataxia and Palatal Tremor (PAPT) and a Literature Review

Silimon,

Wiest,

Bassetti

2023

CTN

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PAPT syndrome is a rare neurologic disorder characterized by progressive ataxia and palatal tremor (rhythmic movements of the soft palate). The first large study of PAPT patients was published in 2004, included a total of 28 sporadic PAPT cases, and suggested a neurodegenerative origin. In the last several years, case reports and small case series followed, underlining the heterogeneity of the clinical picture and underlying aetiology (including neurodegenerative, vascular, infectious/autoimmune, and genetic). As a contribution to the literature, we report on four new patients with PAPT syndrome from Bern. Our study highlights the diverse clinical presentation (pyramidal, extrapyramidal, bulbar, cognitive, psychiatric symptoms, and autonomic features), summarizes the known literature, and extends it by findings on sleep studies (obstructive/central sleep apnoea, sleep disturbance). Possible aetiologies and management aspects are discussed in light of the current literature.

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Section: Patientsupporting

confidence: 83%

Four New Cases of Progressive Ataxia and Palatal Tremor (PAPT) and a Literature Review

Silimon,

Wiest,

Bassetti

2023

CTN

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Progressive ataxia and palatal tremor: Two autopsy cases of a novel tauopathy

et al. 2017

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An elderly man with progressive ataxia and palatal tremor presenting with dizziness and oculopalatal tremor

Tsukahara

Suzuki²,

Kokubun³

et al. 2016

Rinsho Shinkeigaku

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A 74-year-old man was referred to our department for dizziness and progressive unsteady gait over 6 years. His family history was unremarkable. Neurological examination showed dysarthria, saccadic eye movement, palatal tremor (1.7 Hz)-synchronous with rotational ocular movement, and truncal ataxia. T2-weighted magnetic resonance imaging (MRI) of the brain revealed hyperintense and hypertrophic bilateral inferior olivary nuclei at the medulla and mild cerebellar atrophy. On the basis of neurological findings of oculopalatal tremor and cerebellar ataxia with brain MRI findings, the diagnosis of progressive ataxia and palatal tremor (PAPT) was made. PAPT should be included in differential diagnosis of dizziness observed in elderly individuals.

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Neuroimaging features of progressive ataxia and palatal tremor

Cited by 3 publications

References 2 publications

Four New Cases of Progressive Ataxia and Palatal Tremor (PAPT) and a Literature Review

Four New Cases of Progressive Ataxia and Palatal Tremor (PAPT) and a Literature Review

Progressive ataxia and palatal tremor: Two autopsy cases of a novel tauopathy

An elderly man with progressive ataxia and palatal tremor presenting with dizziness and oculopalatal tremor

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