Paracoccidioidomycosis: a rare cause of infectious encephalomyelopathy

Souza, Paulo Victor Sgobbi de; Pinto, Wladimir Bocca Vieira de Rezende; Matas, Sandro Luiz de Andrade

doi:10.1590/0004-282x20140162

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…One more study was excluded after a review of the full text because of insufficient patient data. In conclusion, we included 34 manuscripts, with 104 new cases of NPCM 2,6,12,14–44 . We present the flow diagram in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging

Oliveira

Magri

Levin

et al. 2022

Mycoses

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Paracoccidioidomycosis (PCM) is a systemic fungal infection caused by thermally dimorphic fungi of two main species: Paracoccidioides brasiliensis (P. brasiliensis) and Paracoccidioides lutzii (P. lutzii). 1 The distribution of PCM includes subtropical regions and endemic countries with mild temperature and high and constant humidity. 2,3 It is considered the most important deep mycosis in Latin America, 4,5 especially in Brazil, responsible for the majority of reported cases. 3,6

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Section: Resultsmentioning

confidence: 99%

Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging

Oliveira

Magri

Levin

et al. 2022

Mycoses

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“…Host factors as susceptibility and resistance to infection modulate the granuloma formation in experimental models 51 . However, disease establishment and progression rely on virulence, antigenic profile, environmental conditions, and host immune responses 52 . Macrophages constitute part of the granuloma structure 53 in the typical inflammatory tissue response to Paracoccidioides spp.…”

Section: Discussionmentioning

confidence: 99%

Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis

Marcos

Tamer

Oliveira

et al. 2019

Sci Rep

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The genus Paracoccidioides consist of dimorphic fungi geographically limited to the subtropical regions of Latin America, which are responsible for causing deep systemic mycosis in humans. However, the molecular mechanisms by which Paracoccidioides spp. causes the disease remain poorly understood. Paracoccidioides spp. harbor genes that encode proteins involved in host cell interaction and mitochondrial function, which together are required for pathogenicity and mediate virulence. Previously, we identified TufM (previously known as EF-Tu) in Paracoccidioides brasiliensis (PbTufM) and suggested that it may be involved in the pathogenicity of this fungus. In this study, we examined the effects of downregulating PbTUFM using a silenced strain with a 55% reduction in PbTUFM expression obtained by antisense-RNA (aRNA) technology. Silencing PbTUFM yielded phenotypic differences, such as altered translation elongation, respiratory defects, increased sensitivity of yeast cells to reactive oxygen stress, survival after macrophage phagocytosis, and reduced interaction with pneumocytes. These results were associated with reduced virulence in Galleria mellonella and murine infection models, emphasizing the importance of PbTufM in the full virulence of P. brasiliensis and its potential as a target for antifungal agents against paracoccidioidomycosis.

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“…The more frequently involved spinal levels were thoracic (58%), cervical (25%) or both (8%). Around 20 cases have been published describing NPCM on the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Autopsy and biopsy study of paracoccidioidomycosis and neuroparacoccidioidomycosis with and without HIV co‐infection

Almeida

Roza

Salvador

et al. 2018

Mycoses

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Paracoccidioidomycosis (PCM) is a systemic mycosis prevalent among immunocompetent patients in Latin America. This study aimed to describe the frequency, demographics and clinical characteristics of central nervous system PCM (NPCM) and PCM in an endemic region, and the impact of human immunosuppression virus (HIV) co-infection. This was a retrospective study of autopsy and biopsy reports from the Medical Pathology Section of the Hospital de Clinicas, UFPR, Curitiba, Southern Brazil, between 1951 and 2014. PCM was present in 0.1% of 378,323 cases examined, with 5.7% being NPCM. Infection was prevalent in working-age men, agricultural workers and rural residents. Numbers of HIV autopsy cases increased over time, while those of PCM cases decreased. Prevalence of co-infection of HIV/PCM and HIV/NPCM was 1.6%, and 0.4%, respectively. Adrenals were affected more frequently in the NPCM group compared with the PCM group. Mortality was higher on NPCM group. The clinical course of PCM in HIV patients resembles an acute/sub-acute infection. Association of NPCM and HIV is rare, while diagnosis of NPCM is difficult, it should be considered a differential diagnosis in HIV patients who live in, or have visited, endemic areas and present with neurological symptoms.

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Paracoccidioidomycosis: a rare cause of infectious encephalomyelopathy

Cited by 6 publications

References 2 publications

Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging

Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging

Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis

Autopsy and biopsy study of paracoccidioidomycosis and neuroparacoccidioidomycosis with and without HIV co‐infection

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