Bright tongue sign: a diagnostic marker for amyotrophic lateral sclerosis

Souza, Paulo Victor Sgobbi de; Pinto, Wladimir Bocca Vieira de Rezende; Oliveira, Acary Souza Bullé

doi:10.1590/0004-282x20140077

Cited by 6 publications

(3 citation statements)

References 3 publications

(3 reference statements)

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“…The same group of changes linked to the FTD phenotype are also present in the ALS phenotype 9 , although the presence of bilateral thalamic atrophy is rarely described in cases of isolated ALS phenotype 59 . The presence of the "bright tongue sign" in the context of a frontotemporal dementia points to the possibility of associated motor neuron disease 60 .…”

Section: Neuroimaging Studiesmentioning

confidence: 99%

C9orf72-related disorders: expanding the clinical and genetic spectrum of neurodegenerative diseases

Souza

Pinto

Oliveira

2015

Arq. Neuro-Psiquiatr.

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Neurodegenerative diseases represent a heterogeneous group of neurological conditions primarily involving dementia, motor neuron disease and movement disorders. They are mostly related to different pathophysiological processes, notably in family forms in which the clinical and genetic heterogeneity are lush. In the last decade, much knowledge has been acumulated about the genetics of neurodegenerative diseases, making it essential in cases of motor neuron disease and frontotemporal dementia the repeat expansions of C9orf72 gene. This review analyzes the main clinical, radiological and genetic aspects of the phenotypes related to the hexanucleotide repeat expansions (GGGGCC) of C9orf72 gene. Future studies will aim to further characterize the neuropsychological, imaging and pathological aspects of the extra-motor features of motor neuron disease, and will help to provide a new classification system that is both clinically and biologically relevant.Keywords: neurodegenerative diseases, motor neuron disease, frontotemporal dementia, parkinsonism, C9orf72. RESUMOAs doenças neurodegenerativas representam um grupo heterogêneo de condições neurológicas envolvendo fundamentalmente síndromes demenciais, doenças do neurônio motor e distúrbios de movimento. Relacionam-se, em sua maioria, a processos fisiopatológicos distintos, destacadamente nas formas familiares em que a heterogeneidade clínica e genética são exuberantes. Na última década, muito conhecimento se acumulou a respeito da genética das doenças neurodegenerativas, tornando-se bastante importante nos casos de doenças do neurônio motor e de demência frontotemporal as expansões de repetições do gene C9orf72. Esta revisão aborda os principais aspectos clínicos, radiológicos e genéticos relativos aos fenótipos relacionados à expansão de repetição do hexanucleotídeo (GGGGCC) no gene C9orf72. Estudos futuros vão objetivar a caracterização dos aspectos neuropsicológicos, de imagem e patológicos dos achados extra-motores da doença do neurônio motor e ajudarão a fornecer um novo sistema de classificação relevante em termos clínicos e biológicos.Palavras-chave: doenças neurodegenerativas, doença do neurônio motor, demência frontotemporal, parkinsonismo, C9orf72.

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Section: Neuroimaging Studiesmentioning

confidence: 99%

C9orf72-related disorders: expanding the clinical and genetic spectrum of neurodegenerative diseases

Souza

Pinto

Oliveira

2015

Arq. Neuro-Psiquiatr.

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“…Tongue abnormalities on MRI were reported as bright tongue sign in patients with ALS. 1,2 This is the first report describing the progression of bright tongue sign in ALS. This case suggests that repeat MRI examinations can be useful in assessing potential tongue atrophy in patients with ALS.…”

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confidence: 91%

Time course of bright tongue sign in amyotrophic lateral sclerosis

Miyaue

Yabe

2021

Neurology & Clinical Neurosc

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“…Nevertheless, tongue features seem to be mostly related to the syndrome rather than the disease itself [11]. Previously it was found that lung diseases, such as tuberculosis, amyotrophic lateral sclerosis, a chronic obstructive pulmonary disease characterized with corresponding tongue manifestations [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Tongue Color-Associated Features among Patients with PCR-Confirmed COVID-19 Infection in Ukraine

Horzov

Goncharuk-Khomyn

Hema-Bahyna

et al. 2021

Pesqui. Bras. Odontopediatria Clín. Integr.

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To evaluate and systematize tongue color-related manifestations among patients with PCRconfirmed COVID-19 infection. Material and Methods: This retrospective study included analysis of tongue images obtained from patients with PCR-confirmed COVID-19 infection. Evaluation of coronavirus disease severity (mild, moderate, severe, critical) was provided, considering clinical symptomatology and results of laboratorial and instrumental diagnostic methods. Each picture was analyzed considering the parameters of color of the tongue and color of the tongue plaque by two dental specialists. Cochran-Armitage test for trend was used to evaluate associations between the tongue color and tongue plaque color, and coronavirus disease severity. Results: The most prevalent tongue colors were pale pink, red and dark red (burgundy color). A total of 64.29% of patients with mild disease demonstrated pale pink color of the tongue. Patients with moderate coronavirus disease were characterized with the adverse trend: 62.35% of them presented with red-colored tongue, while in 37.64% of cases, the tongue was pale pink. Severe COVID-19 patients, almost in 90% of the cases, had either red or burgundy color of the tongue. Conclusion: SARS-COV-2 infection is not manifested by tongue-targeted or tongue-specific signs and features; however, coronavirus disease itself provokes changes within the tongue color and tongue plaque color similar to those registered during other internal pathologies.

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Bright tongue sign: a diagnostic marker for amyotrophic lateral sclerosis

Cited by 6 publications

References 3 publications

C9orf72-related disorders: expanding the clinical and genetic spectrum of neurodegenerative diseases

C9orf72-related disorders: expanding the clinical and genetic spectrum of neurodegenerative diseases

Time course of bright tongue sign in amyotrophic lateral sclerosis

Analysis of Tongue Color-Associated Features among Patients with PCR-Confirmed COVID-19 Infection in Ukraine

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